中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2013年
1期
44-47
,共4页
暴丽莎%刘芳%郭志梅%杜志方
暴麗莎%劉芳%郭誌梅%杜誌方
폭려사%류방%곽지매%두지방
振幅整合脑电图%窒息%缺氧缺血性脑病%婴儿,新生
振幅整閤腦電圖%窒息%缺氧缺血性腦病%嬰兒,新生
진폭정합뇌전도%질식%결양결혈성뇌병%영인,신생
Amplitude-integrated electroencephalogram%Asphyxia%Hypoxic-ischemic encephalopathy%Infant,newborn
目的 了解振幅整合脑电图(amplitude-integrated electroencephalogram,aEEG)在新生儿窒息后缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)中的变化规律.方法 选择2011年8月至2012年1月入住白求恩国际和平医院新生儿重症监护病房的35例窒息合并HIE的足月新生儿为HIE组,胎龄为37～41周,同时选取40例足月正常新生儿作为对照组.采用国产脑功能监护仪(CF3000)分别对研究对象于生后24～48 h内监测aEEG波谱带的变化,每次连续监测8h,从振幅波形的连续性、睡眠-觉醒周期及其振幅的高低来分析aEEG的变化.结果 (1)HIE组35例患儿aEEG最高振幅为16 μV,最低振幅为7μV,而对照组最高振幅为30 μV,最低振幅为13 μV,两组间比较差异有统计学意义(P＜0.05)；(2) HIE组患儿的睡眠-觉醒周期出现率与对照组比较[20％ (7/35) vs 100％(40/40)],差异有统计学意义(x2=51.064,P＜0.05),其出现连续性振幅比率与对照组比较[31％(11/35) vs 100％ (40/40)],差异有统计学意义(x2=40.336,P＜0.05).结论 窒息后脑损伤aEEG有特异性表现,可较早预测窒息后引起的脑损伤,对HIE的早期诊断和治疗提供依据.
目的 瞭解振幅整閤腦電圖(amplitude-integrated electroencephalogram,aEEG)在新生兒窒息後缺氧缺血性腦病(hypoxic-ischemic encephalopathy,HIE)中的變化規律.方法 選擇2011年8月至2012年1月入住白求恩國際和平醫院新生兒重癥鑑護病房的35例窒息閤併HIE的足月新生兒為HIE組,胎齡為37～41週,同時選取40例足月正常新生兒作為對照組.採用國產腦功能鑑護儀(CF3000)分彆對研究對象于生後24～48 h內鑑測aEEG波譜帶的變化,每次連續鑑測8h,從振幅波形的連續性、睡眠-覺醒週期及其振幅的高低來分析aEEG的變化.結果 (1)HIE組35例患兒aEEG最高振幅為16 μV,最低振幅為7μV,而對照組最高振幅為30 μV,最低振幅為13 μV,兩組間比較差異有統計學意義(P＜0.05)；(2) HIE組患兒的睡眠-覺醒週期齣現率與對照組比較[20％ (7/35) vs 100％(40/40)],差異有統計學意義(x2=51.064,P＜0.05),其齣現連續性振幅比率與對照組比較[31％(11/35) vs 100％ (40/40)],差異有統計學意義(x2=40.336,P＜0.05).結論 窒息後腦損傷aEEG有特異性錶現,可較早預測窒息後引起的腦損傷,對HIE的早期診斷和治療提供依據.
목적 료해진폭정합뇌전도(amplitude-integrated electroencephalogram,aEEG)재신생인질식후결양결혈성뇌병(hypoxic-ischemic encephalopathy,HIE)중적변화규률.방법 선택2011년8월지2012년1월입주백구은국제화평의원신생인중증감호병방적35례질식합병HIE적족월신생인위HIE조,태령위37～41주,동시선취40례족월정상신생인작위대조조.채용국산뇌공능감호의(CF3000)분별대연구대상우생후24～48 h내감측aEEG파보대적변화,매차련속감측8h,종진폭파형적련속성、수면-각성주기급기진폭적고저래분석aEEG적변화.결과 (1)HIE조35례환인aEEG최고진폭위16 μV,최저진폭위7μV,이대조조최고진폭위30 μV,최저진폭위13 μV,량조간비교차이유통계학의의(P＜0.05)；(2) HIE조환인적수면-각성주기출현솔여대조조비교[20％ (7/35) vs 100％(40/40)],차이유통계학의의(x2=51.064,P＜0.05),기출현련속성진폭비솔여대조조비교[31％(11/35) vs 100％ (40/40)],차이유통계학의의(x2=40.336,P＜0.05).결론 질식후뇌손상aEEG유특이성표현,가교조예측질식후인기적뇌손상,대HIE적조기진단화치료제공의거.
Objective To prospectively observe the changes of amplitude-integrated electroencephalogram(aEEG) in neonates with hypoxic-ischemic encephalopathy (HIE).Methods Thirty-five HIE neonates with gestational age of 37 ～ 41 weeks were chosen as HIE group,and all of them were hospitalized in neonatal intensive care unit of Bethune International Peace Hospital from Aug 2011 to Jan 2012.At the same time,40 healthy term neonates were chosen as control group.aEEG monitoring was done within 24 ～ 48 hours after birth with cerebral function monitor (CF3000) and each recording last at least 8 hours.The continuity,sleep-wake cycle,voltage of every aEEG tracing were analyzed.Results (1) The maximal voltage of aEEG tracing in control group was 30 μV,while that in HIE group was 16 μV.The minimal voltage of aEEG tracing in control group was 13 μV,while that in HIE group was 7 μV.The aEEG tracing amplitude both in highest and lowest in HIE group were significantly lower than those in the control group.There were significant differences between them (P ＜ 0.05).(2) There was significant difference of sleep-wake cycling between HIE group and control group[20％ (7/35) vs 100％ (40/40),x2 =51.064,P ＜ 0.05].While there was also significant difference of the continuity of the amplitude between HIE group and control group[31％ (11/35)vs 100％ (40/40),x2 =40.336,P ＜0.05].Conclusion aEEG has some specific changes in neonates with HIE,possiblility it can be used for earlier predicting the occurrence of brain damage after asphyxia and provides good evidence for the early diagnosis and treatment of HIE.
