中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2013年
1期
52-54,61
,共4页
左卡尼丁%心肌损害%治疗%婴儿,新生
左卡尼丁%心肌損害%治療%嬰兒,新生
좌잡니정%심기손해%치료%영인,신생
Carnitine%Myocardial injury%Therapy%Infant,newborn
目的 探讨左卡尼丁对新生儿缺氧缺血性心肌损害的保护作用.方法 缺氧缺血性心肌损害新生儿60例,分为对照组与试验组各30例,试验组给予果糖二磷酸钠注射液加左卡尼丁注射液治疗,对照组仅给予果糖二磷酸钠注射液治疗,疗程均为7d,观察患儿临床症状、心率、血压、尿量、心肌酶谱、肌钙蛋白及心电图变化.结果 试验组治疗后临床症状改善,总有效率为93.3％ (28/30),对照组总有效率为66.7％(20/30),两组比较差异有统计学意义(x2 =6.667,P =0.01).试验组治疗后心率明显好转,与治疗前比较,差异有统计学意义(t=-6.131,P＜0.01)；但与对照组治疗后比较差异无统计学意义(P＞0.05).试验组治疗后血压及尿量改善,与治疗前及对照组治疗后比较,差异均有统计学意义(P＜0.05).试验组治疗后血清肌酸激酶、肌酸激酶同工酶均显著下降,与对照组比较,差异有统计学意义(P＜0.05).对照组及试验组治疗后肌钙蛋白均有下降趋势,但与治疗前比较差异均无统计学意义(P＞0.05).两组治疗后心电图好转率比较差异无统计学意义(P＞0.05).结论 左卡尼丁可对缺血再灌注心肌发挥保护作用.
目的 探討左卡尼丁對新生兒缺氧缺血性心肌損害的保護作用.方法 缺氧缺血性心肌損害新生兒60例,分為對照組與試驗組各30例,試驗組給予果糖二燐痠鈉註射液加左卡尼丁註射液治療,對照組僅給予果糖二燐痠鈉註射液治療,療程均為7d,觀察患兒臨床癥狀、心率、血壓、尿量、心肌酶譜、肌鈣蛋白及心電圖變化.結果 試驗組治療後臨床癥狀改善,總有效率為93.3％ (28/30),對照組總有效率為66.7％(20/30),兩組比較差異有統計學意義(x2 =6.667,P =0.01).試驗組治療後心率明顯好轉,與治療前比較,差異有統計學意義(t=-6.131,P＜0.01)；但與對照組治療後比較差異無統計學意義(P＞0.05).試驗組治療後血壓及尿量改善,與治療前及對照組治療後比較,差異均有統計學意義(P＜0.05).試驗組治療後血清肌痠激酶、肌痠激酶同工酶均顯著下降,與對照組比較,差異有統計學意義(P＜0.05).對照組及試驗組治療後肌鈣蛋白均有下降趨勢,但與治療前比較差異均無統計學意義(P＞0.05).兩組治療後心電圖好轉率比較差異無統計學意義(P＞0.05).結論 左卡尼丁可對缺血再灌註心肌髮揮保護作用.
목적 탐토좌잡니정대신생인결양결혈성심기손해적보호작용.방법 결양결혈성심기손해신생인60례,분위대조조여시험조각30례,시험조급여과당이린산납주사액가좌잡니정주사액치료,대조조부급여과당이린산납주사액치료,료정균위7d,관찰환인림상증상、심솔、혈압、뇨량、심기매보、기개단백급심전도변화.결과 시험조치료후림상증상개선,총유효솔위93.3％ (28/30),대조조총유효솔위66.7％(20/30),량조비교차이유통계학의의(x2 =6.667,P =0.01).시험조치료후심솔명현호전,여치료전비교,차이유통계학의의(t=-6.131,P＜0.01)；단여대조조치료후비교차이무통계학의의(P＞0.05).시험조치료후혈압급뇨량개선,여치료전급대조조치료후비교,차이균유통계학의의(P＜0.05).시험조치료후혈청기산격매、기산격매동공매균현저하강,여대조조비교,차이유통계학의의(P＜0.05).대조조급시험조치료후기개단백균유하강추세,단여치료전비교차이균무통계학의의(P＞0.05).량조치료후심전도호전솔비교차이무통계학의의(P＞0.05).결론 좌잡니정가대결혈재관주심기발휘보호작용.
Objective To explore the effects of L-carnitine on newborn with hypoxic ischemic myocardial injury.Methods Sixty cases with hypoxic ischemic myocardial injury were divided into two groups,including control group (n =30) receiving fructose sodium diphosphate injection,and experimental group (n =30) receiving both fructose sodium diphosphate and L-carnitine injection for 7 days.The clinical symptoms,changes of heart rates,blood pressure,volume of urine,lactic acid dehydrogenase,creatine kinase,creatine kinase-MB,cardiac troponin Ⅰ and electrocardiogram were investigated before and after treatment.Results Treatment with L-carnitine improved the symptoms of hypoxic ischemic myocardial injury,the total effective rate was 93.3％ (28/30),versus 66.7％ (20/30) in control group,the difference was statistically significant(x2 =6.667,P =0.01).Heart rates of the experimental group were significantly improved after treatment(t =-6.131,P ＜0.01),compared with the control group,there were no significant differences (P ＞ 0.05).Blood pressure and urine volume of experimental group both increased after treatment (P ＜0.05),compared with the control group,the differences were statistically significant (P ＜ 0.05).Creatine kinase and creatine kinase-MB significantly decreased after treatment,compared with the control group (P ＜ 0.05).A downward trend of cardiac troponin Ⅰ was observed in both groups,however,there was no statistically significant difference before and after treatment (P ＞ 0.05).After treatment,electrocardiogram improvement rates were no significantly different between the two groups (P ＞ 0.05).Conclusion L-camitine can contribute to protect hypoxic ischemic myocardial from further injury.
