中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2013年
4期
373-375
,共3页
胱抑素C%小儿肺炎%肾功能损害
胱抑素C%小兒肺炎%腎功能損害
광억소C%소인폐염%신공능손해
Cystatin C%Infantile pneumonia%Renal dysfunction
目的 探讨肺炎患儿不同时期的血清胱抑素C(cystatinC,Cys C)变化及其临床价值.方法 对2012年11月至2013年3月收治的92例肺炎患儿(轻症肺炎组59例,重症肺炎组33例),分别于急性期和恢复期检测血清CysC、血肌酐、尿素等指标,同时检测40例健康儿童作为对照组,并对临床病情分度和转归进行对比分析.结果 重症肺炎组急性期血Cys C平均含量(1.98±0.33) mg/L,显著高于对照组(0.85±0.24) mg/L,差异有统计学意义(P＜0.01)；恢复期血Cys C平均含量(1.12±0.23) mg/L,与对照组比较差异无统计学意义(P＞0.05),急性期与恢复期比较差异有统计学意义(P＜0.05).轻症肺炎组急性期和恢复期血Cys C平均含量分别为(1.10±0.22) mg/L和(0.94±0.21) mg/L,与对照组比较,差异均无统计学意义(P＞0.05).重症肺炎组急性期血Cys C异常检出率为51.9％ (14/27),显著高于血尿素和肌酐的异常检出率3.7％ (1/27),差异有统计学意义(P＜0.01).结论 重症肺炎对小儿肾功能有损害,但这种损害是可逆性的.血Cys C测定对伴有肾功能损害的重症肺炎的早期诊断及疗效判断均具有参考价值.
目的 探討肺炎患兒不同時期的血清胱抑素C(cystatinC,Cys C)變化及其臨床價值.方法 對2012年11月至2013年3月收治的92例肺炎患兒(輕癥肺炎組59例,重癥肺炎組33例),分彆于急性期和恢複期檢測血清CysC、血肌酐、尿素等指標,同時檢測40例健康兒童作為對照組,併對臨床病情分度和轉歸進行對比分析.結果 重癥肺炎組急性期血Cys C平均含量(1.98±0.33) mg/L,顯著高于對照組(0.85±0.24) mg/L,差異有統計學意義(P＜0.01)；恢複期血Cys C平均含量(1.12±0.23) mg/L,與對照組比較差異無統計學意義(P＞0.05),急性期與恢複期比較差異有統計學意義(P＜0.05).輕癥肺炎組急性期和恢複期血Cys C平均含量分彆為(1.10±0.22) mg/L和(0.94±0.21) mg/L,與對照組比較,差異均無統計學意義(P＞0.05).重癥肺炎組急性期血Cys C異常檢齣率為51.9％ (14/27),顯著高于血尿素和肌酐的異常檢齣率3.7％ (1/27),差異有統計學意義(P＜0.01).結論 重癥肺炎對小兒腎功能有損害,但這種損害是可逆性的.血Cys C測定對伴有腎功能損害的重癥肺炎的早期診斷及療效判斷均具有參攷價值.
목적 탐토폐염환인불동시기적혈청광억소C(cystatinC,Cys C)변화급기림상개치.방법 대2012년11월지2013년3월수치적92례폐염환인(경증폐염조59례,중증폐염조33례),분별우급성기화회복기검측혈청CysC、혈기항、뇨소등지표,동시검측40례건강인동작위대조조,병대림상병정분도화전귀진행대비분석.결과 중증폐염조급성기혈Cys C평균함량(1.98±0.33) mg/L,현저고우대조조(0.85±0.24) mg/L,차이유통계학의의(P＜0.01)；회복기혈Cys C평균함량(1.12±0.23) mg/L,여대조조비교차이무통계학의의(P＞0.05),급성기여회복기비교차이유통계학의의(P＜0.05).경증폐염조급성기화회복기혈Cys C평균함량분별위(1.10±0.22) mg/L화(0.94±0.21) mg/L,여대조조비교,차이균무통계학의의(P＞0.05).중증폐염조급성기혈Cys C이상검출솔위51.9％ (14/27),현저고우혈뇨소화기항적이상검출솔3.7％ (1/27),차이유통계학의의(P＜0.01).결론 중증폐염대소인신공능유손해,단저충손해시가역성적.혈Cys C측정대반유신공능손해적중증폐염적조기진단급료효판단균구유삼고개치.
Objective To explore the clinical value of the serum cystatin C (Cys C) changes in different periods of the infantile pneumonia.Methods Ninety-two cases of infantile pneumonia (59 mild pneumonia patients and 33 severe pneumonia patients) from November 2012 to March 2013 were collected and 40 cases of healthy infant were enrolled for control group.The levels of serum Cys C,urea and creatinine in acute and recovery period were detected.Results In severe pneumonia patients,the average level of Cys C in acute period [(1.98±0.33) mg/L] is significantly higher than that in control group [(0.85 ±0.24) mg/L] (P ＜0.01),and there was no significant difference between recovery period [(1.12 ± 0.23) mg/L] and control group (P ＞ 0.05),and there was significant difference between acute and recovery period (P ＜0.05).In mild pneumonia patients,there were no significant differences in the level of Cys C between the acute period [(1.10 ±0.22) mg/L] and recovery period [(0.94 ±0.21) mg/L] as well as control group (P ＞ 0.05).The positive rate of Cys C in severe pneumonia patients (51.9％,14/27) was higher than that of urea and creatinine (3.7％,1/27) (P ＜0.01).Conclusion Severe pneumonia could result in renal dysfunction,which is reversible.Cys C can be the clinical reference for early diagnosis and the therapeutic effect in severe pneumonia patients with renal dysfunction.
