中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2013年
6期
599-602
,共4页
脓毒症%高迁移率族蛋白B1%炎症介质%儿童
膿毒癥%高遷移率族蛋白B1%炎癥介質%兒童
농독증%고천이솔족단백B1%염증개질%인동
Sepsis%High mobility group box 1%Inflammatory mediator%Children
目的 探讨血清高迁移率族蛋白B1(high mobility group box 1,HMGB1)在儿童脓毒症中的变化及临床意义.方法 检测30例健康体检儿童和46例脓毒症患儿入院第1天血清HMGB1浓度及降钙素原(procalcitonin,PCT)水平,并对脓毒症患儿进行急性生理与慢性健康状态评分(acute physiology and chronic health evaluationⅡ,APACHEⅡ),于入院后第3、5天同样采集上述指标,将HMGB1与PCT及APACHEⅡ评分进行相关性分析.结果 儿童脓毒症组第1天、第3天及第5天血清HMGB1水平均显著高于对照组,差异有统计学意义[(26.28±1.54) ng/ml,(20.32±1.29) ng/ml,(12.84±1.06) ng/ml vs (1.52±0.29) ng/ml,P＜0.05],脓毒症组各时间点间HMGB1水平比较差异亦具有统计学意义(P＜0.05),且血清HMGB1水平与PCT水平呈正相关(r =0.931,P＜0.05),与APACHEⅡ评分呈正相关(r=0.915,P＜0.05).结论 儿童脓毒症时血清HMGB1水平明显升高,且其水平与病情严重程度相关.
目的 探討血清高遷移率族蛋白B1(high mobility group box 1,HMGB1)在兒童膿毒癥中的變化及臨床意義.方法 檢測30例健康體檢兒童和46例膿毒癥患兒入院第1天血清HMGB1濃度及降鈣素原(procalcitonin,PCT)水平,併對膿毒癥患兒進行急性生理與慢性健康狀態評分(acute physiology and chronic health evaluationⅡ,APACHEⅡ),于入院後第3、5天同樣採集上述指標,將HMGB1與PCT及APACHEⅡ評分進行相關性分析.結果 兒童膿毒癥組第1天、第3天及第5天血清HMGB1水平均顯著高于對照組,差異有統計學意義[(26.28±1.54) ng/ml,(20.32±1.29) ng/ml,(12.84±1.06) ng/ml vs (1.52±0.29) ng/ml,P＜0.05],膿毒癥組各時間點間HMGB1水平比較差異亦具有統計學意義(P＜0.05),且血清HMGB1水平與PCT水平呈正相關(r =0.931,P＜0.05),與APACHEⅡ評分呈正相關(r=0.915,P＜0.05).結論 兒童膿毒癥時血清HMGB1水平明顯升高,且其水平與病情嚴重程度相關.
목적 탐토혈청고천이솔족단백B1(high mobility group box 1,HMGB1)재인동농독증중적변화급림상의의.방법 검측30례건강체검인동화46례농독증환인입원제1천혈청HMGB1농도급강개소원(procalcitonin,PCT)수평,병대농독증환인진행급성생리여만성건강상태평분(acute physiology and chronic health evaluationⅡ,APACHEⅡ),우입원후제3、5천동양채집상술지표,장HMGB1여PCT급APACHEⅡ평분진행상관성분석.결과 인동농독증조제1천、제3천급제5천혈청HMGB1수평균현저고우대조조,차이유통계학의의[(26.28±1.54) ng/ml,(20.32±1.29) ng/ml,(12.84±1.06) ng/ml vs (1.52±0.29) ng/ml,P＜0.05],농독증조각시간점간HMGB1수평비교차이역구유통계학의의(P＜0.05),차혈청HMGB1수평여PCT수평정정상관(r =0.931,P＜0.05),여APACHEⅡ평분정정상관(r=0.915,P＜0.05).결론 인동농독증시혈청HMGB1수평명현승고,차기수평여병정엄중정도상관.
Objective To investigate the change of serum HMGB1 level and its clinical significance in children with sepsis.Methods Serum HMGB1 and procalcitonin (PCT) levels were determined in 30 healthy individuals and 46 children with sepsis,and the acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scoring system was evaluated in children with sepsis.These indexes were also collected on the third and fifth days.The correlations between serum HMGB1 level and serum PCT level as well as APACHE Ⅱ score were analyzed.Results Serum HMGB1 levels in children with sepsis on the first day,the third day and the fifth day were significantly higher than those in control group,these differences were statistically significant [(26.28 ± 1.54) ng/ml,(20.32 ± 1.29) ng/ml,(12.84 ± 1.06) ng/ml vs (1.52 ± 0.29) ng/ml,P ＜0.05],HMGB1 levels among three time points were also significantly different(P ＜0.05).The serum HMGB 1 levels were positively correlated with the PCT levels (r =0.931,P ＜ 0.05) and APACHE Ⅱ score (r =0.915,P ＜ 0.05).Conclusion Serum HMGB1 level is obviously elevated in children with sepsis,and the level of HMGB1 can reflect the severity of sepsis.
