中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2014年
9期
566-568
,共3页
反复呼吸道感染%肺炎球菌%流感%疫苗%健康相关生活质量
反複呼吸道感染%肺炎毬菌%流感%疫苗%健康相關生活質量
반복호흡도감염%폐염구균%류감%역묘%건강상관생활질량
Recurrent respiratory tract infections%Pneumococcal%Influenza%Vaccine%Health-related quality of life
目的 观察肺炎球菌疫苗与流感疫苗联合接种对反复呼吸道感染(recurrent respiratory tract infection,RRTI)患儿健康相关生活质量的影响.方法 454例RRTI患儿分为4组,对照组(n=135)仪使用安慰剂,联合接种组(n=143)联合接种肺炎球菌疫苗与流感疫苗,肺炎球菌疫苗组(n=95)、流感疫苗组(n=81).观察4组患儿相关临床指标以及接种前、接种后14个月时的PedsQLTM4.0评分.结果 4组患儿在例数、性别、年龄、病程及社会经济地位评分等方面比较差异无统计学意义(P＞0.05);治疗后肺炎球菌疫苗组、流感疫苗组和联合接种组患儿上、下呼吸道感染次数,呼吸道疾病所致发热次数,抗生素使用天数及总治疗费用均明显少于对照组(P＜0.01),并且联合接种组明显优于单纯肺炎球菌疫苗组、流感疫苗组(P＜0.01);接种前PedsQLTM4.0评分比较差异无统计学意义(P＞0.05),接种后各组各维度生活质量均明显提高(P＜0.05),而对照组差异无统计学意义(P＞0.05).结论 肺炎球菌疫苗与流感疫苗联合接种可有效改善RRTI患儿的健康相关生活质量,明显提高PedsQLTM 4.0评分,值得临床推广应用.
目的 觀察肺炎毬菌疫苗與流感疫苗聯閤接種對反複呼吸道感染(recurrent respiratory tract infection,RRTI)患兒健康相關生活質量的影響.方法 454例RRTI患兒分為4組,對照組(n=135)儀使用安慰劑,聯閤接種組(n=143)聯閤接種肺炎毬菌疫苗與流感疫苗,肺炎毬菌疫苗組(n=95)、流感疫苗組(n=81).觀察4組患兒相關臨床指標以及接種前、接種後14箇月時的PedsQLTM4.0評分.結果 4組患兒在例數、性彆、年齡、病程及社會經濟地位評分等方麵比較差異無統計學意義(P＞0.05);治療後肺炎毬菌疫苗組、流感疫苗組和聯閤接種組患兒上、下呼吸道感染次數,呼吸道疾病所緻髮熱次數,抗生素使用天數及總治療費用均明顯少于對照組(P＜0.01),併且聯閤接種組明顯優于單純肺炎毬菌疫苗組、流感疫苗組(P＜0.01);接種前PedsQLTM4.0評分比較差異無統計學意義(P＞0.05),接種後各組各維度生活質量均明顯提高(P＜0.05),而對照組差異無統計學意義(P＞0.05).結論 肺炎毬菌疫苗與流感疫苗聯閤接種可有效改善RRTI患兒的健康相關生活質量,明顯提高PedsQLTM 4.0評分,值得臨床推廣應用.
목적 관찰폐염구균역묘여류감역묘연합접충대반복호흡도감염(recurrent respiratory tract infection,RRTI)환인건강상관생활질량적영향.방법 454례RRTI환인분위4조,대조조(n=135)의사용안위제,연합접충조(n=143)연합접충폐염구균역묘여류감역묘,폐염구균역묘조(n=95)、류감역묘조(n=81).관찰4조환인상관림상지표이급접충전、접충후14개월시적PedsQLTM4.0평분.결과 4조환인재례수、성별、년령、병정급사회경제지위평분등방면비교차이무통계학의의(P＞0.05);치료후폐염구균역묘조、류감역묘조화연합접충조환인상、하호흡도감염차수,호흡도질병소치발열차수,항생소사용천수급총치료비용균명현소우대조조(P＜0.01),병차연합접충조명현우우단순폐염구균역묘조、류감역묘조(P＜0.01);접충전PedsQLTM4.0평분비교차이무통계학의의(P＞0.05),접충후각조각유도생활질량균명현제고(P＜0.05),이대조조차이무통계학의의(P＞0.05).결론 폐염구균역묘여류감역묘연합접충가유효개선RRTI환인적건강상관생활질량,명현제고PedsQLTM 4.0평분,치득림상추엄응용.
Objective To observe the health-related quality of life of children with recurrent respiratory tract infection (RRTI) simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine.Methods A total of 454 cases with RRTI were randomly divided into four groups,the control group (n =135) was used with placebo only,and the combined inoculation group (n =143) was simultaneously inoculated with pneumococcal vaccine combined with influenza vaccine,the pneumococcus vaccine group (n =95),influenza vaccine group (n =81).The PedsQLTM 4.0 score and clinical indicators were observed in each group before the inoculation and 14 months after the inoculation.Results There were no significant differences in the number of cases,gender,age,duration and socioeconomic status score in the four groups (P ＞ 0.05).The incidence of upper and lower respiratory tract infection,respiratory diseases caused by the frequency of fever,the number of days of antibiotic use and total cost of treatment in the vaccine group were significantly less than those of the control group (P ＜ 0.05).And the combined inoculation group was significantly better than the pneumococcus vaccine group and influenza vaccine group(P ＜ 0.0l).The PedsQLTM 4.0 score showed no significant differences among four groups (P ＞ 0.05) before the inoculation.Each dimension of the quality of life of the vaccine group significantly increased (P ＜ 0.05) while those of control group showed no significant difference (P ＞ 0.05).Conclusion Combination of inoculation of pneumococcal vaccine and influenza vaccine can effectively improve the health-related quality of life of RRTI children as well as the PedsQLTM 4.0 score,and it should be highly recommended clinically.
