CAJ | 학술논문

胃肠道间质瘤(GIST)是一种较常见的以c-kit基因突变为特征的消化道间叶细胞肿瘤,最常发生于胃.结合B超、CT检查和肿瘤标志物CD117检测多可诊断.手术根治性切除是其最有效的治疗手段.靶向药物可延缓肿瘤复发和远处转移患者的疾病进展.目前对于巨大GIST的诊断及手术、药物治疗时机仍存争议.现就一例巨大胃间质瘤合并巨大腹股沟疝展开讨论,以便为临床制订合理的诊断和治疗措施提供参考.
위장도간질류(GIST)시일충교상견적이c-kit기인돌변위특정적소화도간협세포종류,최상발생우위.결합B초、CT검사화종류표지물CD117검측다가진단.수술근치성절제시기최유효적치료수단.파향약물가연완종류복발화원처전이환자적질병진전.목전대우거대GIST적진단급수술、약물치료시궤잉존쟁의.현취일례거대위간질류합병거대복고구산전개토론,이편위림상제정합리적진단화치료조시제공삼고.
Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors of the digestive tract characterized by c-kit mutations and the stomach is the commonly involved site.Clinical and pathological diagnosis of GISTs can be achieved by B sonography,computed tomography and immunohistochemical detection of marker CD117.Surgical resection of GISTs has been the most effective therapy.Target therapy with tyrosine kinase inhibitors may reduce the development of recurrence or progression of GISTs.The optimized method of diagnosis and treatment of huge GISTs is still controversial.In this paper,the diagnosis and treatment for huge GIST combined with large right inguinal hernia were discussed.