CAJ | 학술논문

目的探讨颅骨嗜酸性肉芽肿的临床表现、诊断和治疗.方法对2003年1月至2010年12月间我科收治的儿童颅骨嗜酸性肉芽肿48例进行回顾性分析.所有病例术前均行头颅CT检查,其中12例行头颅MRI检查,均行长骨和扁骨的X线片检查,均行手术治疗和病理检查.结果顶骨为好发骨.1例多发,1例合并锁骨病变.所有病例均行手术全切,术后均未行放疗.15例因局部硬脑膜、帽状腱膜受浸,术后应用吲哚美辛治疗6周.随访6个月至7年(平均3.2年),均无复发.结论颅骨嗜酸性肉芽肿为良性病变,在诊断时需警惕多发病灶.手术切除是单发病灶的最佳治疗方法,术后不需要侵袭性化疗和放疗,预后好.
목적 탐토로골기산성육아종적림상표현、진단화치료.방법 대2003년1월지2010년12월간아과수치적인동로골기산성육아종48례진행회고성분석.소유병례술전균행두로CT검사,기중12례행두로MRI검사,균행장골화편골적X선편검사,균행수술치료화병리검사.결과 정골위호발골.1례다발,1례합병쇄골병변.소유병례균행수술전절,술후균미행방료.15례인국부경뇌막、모상건막수침,술후응용신타미신치료6주.수방6개월지7년(평균3.2년),균무복발.결론 로골기산성육아종위량성병변,재진단시수경척다발병조.수술절제시단발병조적최가치료방법,술후불수요침습성화료화방료,예후호.
Objective To investigate the clinical manifestation,the diagnosis and treatment of skull eosinophilic granuloma.Methods 48 patients with skull eosinophilic granuloma admitted into Children's Hospital of Chongqing Medical University from July 2003 to December 2009 were analyzed retrospectively.They were all preoperatively evaluated by skull x-ray and computed tomography,with 12 patients additionally underwent magnetic resonance imaging.To rule out multifocal disease,long bone and flat bone X-rays were performed in all cases preoperatively.Surgical excision of the lesions was performed,and EG was proven histologically.Results Parietal bone was the most commonly affected bone.One patient had multifocal disease.One patient combined lesions of the clavicle.Total excision of the lesion was performed in all cases.No patient received postoperative radiotherapy.15 cases had involvement of the dura and the galea aponeurotica.These patients were further treated with indomethacin for 6 weeks.Follow-up examinations ranged from 6 months to 7 years,with a mean follow-up period of 3.2 years.No tumor recurrence was noted.Conclusions Skull eosinophilic granuloma is a benign disease.At the time of diagnosis,a bone scan should be performed to rule out multifocal disease.Surgical resection is the treatment of choice.No aggressive chemotherapy and radiotherapy after surgery is needed.The overall prognosis for EG of the skull is good.