中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2012年
11期
1022-1025
,共4页
干眼%泪液渗透压%眼表
榦眼%淚液滲透壓%眼錶
간안%루액삼투압%안표
Dry eye%Tear osmolarity%Ocular surface
背景 干眼的发病率逐渐增加,但目前尚无统一的诊断标准.近年的研究提示,泪液渗透压增高可导致眼表不适症状,2007年国际干眼工作小组(DEWS)将泪液渗透压作为伴随症状写入干眼定义中,因此研究泪液渗透压与干眼的关系有重要的临床意义. 目的 依据DEWS干眼严重程度分级标准,分析泪液渗透压与干眼严重程度的相关性.方法 采用描述性研究方法,收集在河南省眼科研究所经传统诊断方法诊断为干眼的患眼54例54眼,询问患者的眼部症状,裂隙灯显微镜下观察眼前节表现,同时行Schirmer试验Ⅰ(SⅠt)、泪膜破裂时间(BUT)试验、泪膜影像学检查、角膜荧光素染色以及泪液渗透压试验,参照和结合DEWS的标准对干眼表现进行评分,将干眼症状评分与泪液渗透压进行相关分析. 结果 男性发病与女性发病的比例为1:2.泪液渗透压与SⅠt、BUT均呈明显负相关(r=-0.456、-0.699,P＜0.01),与泪膜影像学检查值、角膜荧光素染色评分、结膜充血评分、干眼严重程度评分均呈显著正相关(r=0.545、0.686、0.691、0.803,P＜0.01),与年龄、性别相关(β1=141.138,P=0.000;β2=1.845,P=0.049). 结论 泪液渗透压检测可客观地反映干眼的严重程度,结合临床症状和体征可作为干眼严重程度分级的标准.
揹景 榦眼的髮病率逐漸增加,但目前尚無統一的診斷標準.近年的研究提示,淚液滲透壓增高可導緻眼錶不適癥狀,2007年國際榦眼工作小組(DEWS)將淚液滲透壓作為伴隨癥狀寫入榦眼定義中,因此研究淚液滲透壓與榦眼的關繫有重要的臨床意義. 目的 依據DEWS榦眼嚴重程度分級標準,分析淚液滲透壓與榦眼嚴重程度的相關性.方法 採用描述性研究方法,收集在河南省眼科研究所經傳統診斷方法診斷為榦眼的患眼54例54眼,詢問患者的眼部癥狀,裂隙燈顯微鏡下觀察眼前節錶現,同時行Schirmer試驗Ⅰ(SⅠt)、淚膜破裂時間(BUT)試驗、淚膜影像學檢查、角膜熒光素染色以及淚液滲透壓試驗,參照和結閤DEWS的標準對榦眼錶現進行評分,將榦眼癥狀評分與淚液滲透壓進行相關分析. 結果 男性髮病與女性髮病的比例為1:2.淚液滲透壓與SⅠt、BUT均呈明顯負相關(r=-0.456、-0.699,P＜0.01),與淚膜影像學檢查值、角膜熒光素染色評分、結膜充血評分、榦眼嚴重程度評分均呈顯著正相關(r=0.545、0.686、0.691、0.803,P＜0.01),與年齡、性彆相關(β1=141.138,P=0.000;β2=1.845,P=0.049). 結論 淚液滲透壓檢測可客觀地反映榦眼的嚴重程度,結閤臨床癥狀和體徵可作為榦眼嚴重程度分級的標準.
배경 간안적발병솔축점증가,단목전상무통일적진단표준.근년적연구제시,루액삼투압증고가도치안표불괄증상,2007년국제간안공작소조(DEWS)장루액삼투압작위반수증상사입간안정의중,인차연구루액삼투압여간안적관계유중요적림상의의. 목적 의거DEWS간안엄중정도분급표준,분석루액삼투압여간안엄중정도적상관성.방법 채용묘술성연구방법,수집재하남성안과연구소경전통진단방법진단위간안적환안54례54안,순문환자적안부증상,렬극등현미경하관찰안전절표현,동시행Schirmer시험Ⅰ(SⅠt)、루막파렬시간(BUT)시험、루막영상학검사、각막형광소염색이급루액삼투압시험,삼조화결합DEWS적표준대간안표현진행평분,장간안증상평분여루액삼투압진행상관분석. 결과 남성발병여녀성발병적비례위1:2.루액삼투압여SⅠt、BUT균정명현부상관(r=-0.456、-0.699,P＜0.01),여루막영상학검사치、각막형광소염색평분、결막충혈평분、간안엄중정도평분균정현저정상관(r=0.545、0.686、0.691、0.803,P＜0.01),여년령、성별상관(β1=141.138,P=0.000;β2=1.845,P=0.049). 결론 루액삼투압검측가객관지반영간안적엄중정도,결합림상증상화체정가작위간안엄중정도분급적표준.
Background There still is no a uniform diagnostic criteria for increasing population of dry eye.Studies showed that high tear osmotic pressure is one of causes of a variety of ocular surface discomfort,and the change of tear osmolality has been included in the definition of dry eye syndrome by Dry Eye World Study Group (DEWS) in 2007.It is very clinically significant to study the relationship of tear osmolality with dry eye.Objective This clinical trial was to study the correlation between tear osmolarity and dry eye severity based on Preferred Practice Pattern(PPP)of DEWS.Methods A descriptive study was performed.Fifty-four eyes of 54 patients with dry eye disease were asked to complete an evaluation of dry eye signs and symptoms questionnaire based on PPP.The ocular anterior segment was examined under the slit lamp biomicroscope.Cornealfluorescein staining,tear-film breakup time (BUT),Schirmer test Ⅰ (S Ⅰ t)without anesthesia were performed,and tear sample was collected for tear imageology and tear osmolarity admeasurement.The correlation between dry eye score with tear osmolarity was evaluated using Pearson linear correlation analysis.Written informed consent as obtained prior to any relevant medical procedure.Results The ratio of male and female patients was 1: 2 in this study.The negative correlations were found between tear osmolarity with S Ⅰ t or BUT(r =-0.456,-0.699,P＜0.01),and significantly positive correlations were found between tear osmolarity with tear imaging examination,corneal fluorescein staining,conjunctival hyperemia or dry eye symptom score(r=0.545,0.686,0.691,0.803,P＜0.01).Conclusions As a diagnostic method,tear osmolarity can objectively reflects dry eye severity.It can be a biomarker in dry eye severity grade when combined with clinical symptom.
