CAJ | 학술논문

背景巩膜的活体测量对于了解巩膜本身的厚度及一些相关疾病均有较大帮助. 目的观察年龄相关性白内障人群前部巩膜厚度及其与相关眼部参数间的关系.方法分别采用超声角膜测厚仪、角膜曲率仪及眼部A型超声对105例年龄相关性白内障患者进行双眼中央角膜厚度(CCT)、角膜屈光力(CCV)及眼轴长度测量,同时采用超声生物显微镜(UBM)测量颞侧巩膜突后2 mm处的前部巩膜厚度(AST).分别采用配对t检验及独立样本t检验对不同眼别、不同性别间的CCT、CCV、眼轴长度和AST参数进行比较；采用Pearson积矩线性相关分析法分析上述各参数间的相关性,并采用单因素方差分析比较不同眼轴长度患者CCT及AST的差异. 结果受试者双眼间CCT、CCV、眼轴长度及AST值的差异均无统计学意义(t=0.584,P=0.561；t=1.161,P=0.248；t=0.140-P=0.889；t=0.342,P=0.773).男性组测量的平均CCT厚度值小于女性组,但差异无统计学意义(右眼:t=0.469-P=0.641；左眼:t=0.465,P=0.643)；与女性组比较,男性组的眼轴明显较长,平均CCV值明显降低,平均AST明显增厚,差异均有统计学意义(左右眼均P＜0.01).本组受试者右眼颞侧巩膜突后2 mm处AST为(0.59±0.05)mm.相关分析表明,CCV与眼轴长度呈显著负相关(r=-0.50,P＜0.01),但年龄、CCT、眼轴长度及AST间无明显相关性(P＞0.05).不同眼轴长度组间受试者CCT和AST的差异无统计学意义(CCT:F=0.998,P=0.372；AST:F=1.919,P=0.383). 结论年龄相关性白内障患者的AST与CCT间无明显相关；一定程度的眼轴变长可能不伴随前部眼球壁的变薄；男女间眼部的部分参数可能存在一定差异.
배경 공막적활체측량대우료해공막본신적후도급일사상관질병균유교대방조. 목적 관찰년령상관성백내장인군전부공막후도급기여상관안부삼수간적관계.방법 분별채용초성각막측후의、각막곡솔의급안부A형초성대105례년령상관성백내장환자진행쌍안중앙각막후도(CCT)、각막굴광력(CCV)급안축장도측량,동시채용초성생물현미경(UBM)측량섭측공막돌후2 mm처적전부공막후도(AST).분별채용배대t검험급독립양본t검험대불동안별、불동성별간적CCT、CCV、안축장도화AST삼수진행비교；채용Pearson적구선성상관분석법분석상술각삼수간적상관성,병채용단인소방차분석비교불동안축장도환자CCT급AST적차이. 결과 수시자쌍안간CCT、CCV、안축장도급AST치적차이균무통계학의의(t=0.584,P=0.561；t=1.161,P=0.248；t=0.140-P=0.889；t=0.342,P=0.773).남성조측량적평균CCT후도치소우녀성조,단차이무통계학의의(우안:t=0.469-P=0.641；좌안:t=0.465,P=0.643)；여녀성조비교,남성조적안축명현교장,평균CCV치명현강저,평균AST명현증후,차이균유통계학의의(좌우안균P＜0.01).본조수시자우안섭측공막돌후2 mm처AST위(0.59±0.05)mm.상관분석표명,CCV여안축장도정현저부상관(r=-0.50,P＜0.01),단년령、CCT、안축장도급AST간무명현상관성(P＞0.05).불동안축장도조간수시자CCT화AST적차이무통계학의의(CCT:F=0.998,P=0.372；AST:F=1.919,P=0.383). 결론 년령상관성백내장환자적AST여CCT간무명현상관；일정정도적안축변장가능불반수전부안구벽적변박；남녀간안부적부분삼수가능존재일정차이.
Background The condition of the sclera is associated with many ocular diseases.The measurement of human scleral thickness in vivo is helpful for us to understand the features of the sclera and related diseases.Objective The present study was to measure the anterior sclera thickness(AST) in patients with senile cataract and to analyze the relationship among AST and other associated ocular parameters.Methods This study was approved by the Ethic Commission of First Hospital of Peking University.Written informed consent was obtained from each individual prior to examination.One hundred and five senile cataract patients were recruited in this study.Central corneal thickness (CCT),corneal curvature (CCV) and axial length were measured using ultrasonic pachymeter,keratometer,and A-scan unit,respectively.The AST was measured at 2 mm posterior to the scleral spur in the temporal meridian using ultrasound biomicroscope (UBM).The differences of CCT,CCV,ocular axial length and AST between bilateral eyes and the different sexes were compared by the Paired test and independent sample t test.The correlations among various parameters were assessed by the Pearson linear correlation analysis.The differences of CCT and AST among different axial length groups were evaluated by one-way ANOVA.Results No significant differences were found in the CCT,CCV,axial length and AST between bilateral eyes (t =0.584,P =0.561 ; t =1.161,P =0.248 ; t =0.140,P =0.889 ; t =0.342,P =0.773).Temporal AST at 2 mm posterior to the sclera spur was (0.589 ±0.051)mm in the right eyes.An insignificant decline in CCT was found in the male group compared with the female group (right eyes:t =0.469,P =0.641 ; left eyes:t =0.465,P =0.643).However,compared with the female group,the increase of axial length,reduction of the mean CCV value and enhancement of the mean AST were observed(right eyes:all P＜0.01 ;left eyes:all P＜0.01).CCV showed a negative correlation with ocular axial length (r =-0.50,P＜0.01),but no significant correlation was found among age,CCT,ocular axial length and AST(P＞0.05).No remarkable differences were found in CCT and AST among the various axial length groups (CCT:F =0.998,P=0.372;AST:F=1.919,P=0.383).Conclusions In senile cataract patients,correlation is not found between AST and CCT;the increase of axial length is not associated with the thinning of the eyeball wall to a certain extent.Differences exist in some ocular parameters between different sexes.