RTVue傅里叶光学相干断层扫描仪测量角膜参数的重复性和准确性评价
RTVue부리협광학상간단층소묘의측량각막삼수적중복성화준학성평개
Repeatability and accuracy of corneal parameters measured by RTVue Fourier-domain optical coherence topography
  • 万方数据
    中华实验眼科杂志 중화실험안과잡지
    CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
    2013年 2期 177-181 ,共5页

    华焱军%黄锦海%潘超%王勤美

    화염군%황금해%반초%왕근미

    光学相干断层扫描%Topolyzer%角膜曲率%角膜厚度%生物测量/重复性、一致性 光學相榦斷層掃描%Topolyzer%角膜麯率%角膜厚度%生物測量/重複性、一緻性
    광학상간단층소묘%Topolyzer%각막곡솔%각막후도%생물측량/중복성、일치성
    Optical coherence topography%Topolyzer%Corneal curvature%Corneal thickness%Bio-measurement/ repeatability,agreement
    背景 角膜各参数(如曲率、厚度等)对于诊断角膜源性疾病、角膜接触镜的验配及角膜屈光手术至关重要. 目的 研究RTVue傅里叶光学相干断层扫描仪(FD-OCT)评估角膜各参数的重复性与准确性,为FD-OCT的临床应用提供参考依据.方法 本研究为前瞻性研究.接受准分子激光角膜原位磨镶术(LASIK)术前检查者43例77眼,屈光度为-1.25～-10.00 D,散光度＜2 D.使用RTVue FD-OCT测量角膜中央3 mm直径范围内前表面曲率半径Ranterior、后表面曲率半径Rposterior、角膜后前表面曲率半径之比Rposterior/Ranterior、中央角膜厚度(CCT)、通过厚透镜公式获得角膜总屈光力Knet、模拟角膜屈光力SimK、角膜前表面中央直径3 mm范围内屈光力Kanterior、角膜后表面中央直径3 mm范围内屈光力Kposterior,及基于Placido环原理的Topolyzer获得的角膜屈光力Km,每只受试眼连续测量3次.采用变异系数(CV)、Cronbach Alpha系数及组内相关系数(ICC)评估重复性,重复测量方差分析比较SimK与Knet、Knet与Km、SimK与Km之间的差异性,Pearson相关分析SimK与Knet、Knet与Km、SimK与Km之间的相关性,Bland-Altman分析SimK与Knet、Knet与Km、SimK与Km之间的一致性. 结果 Ranterior、Rposterior、Rposterior／Ranteror、Kanterior、Kposterior、SimK、Knet和CCT分别为(7.691±0.302) mm、(6.532±0.276) mm、0.849±0.014、(48.97±1.92)D、(-6.13±0.26)D、(43.95±1.72)D、(42.95±1.68)D和(545.20±35.04)μm,各参数的CV均＜1％,Cronbach Alpha系数均＞0.9；Rposterior/Ranterior的ICC为0.802,其余参数ICC均＞0.9.SimK比Km大(0.27±0.34)D,Knet比Km小(0.73±0.37)D,SimK比Knet大(1.01±0.11)D,差异均有统计学意义(P＜0.001).SimK与Km、Knet与Km、SimK与Knet均呈正相关(r=0.981、0.976、0.998,P＜0.001).Bland-Altman分析显示,SimK、Knet、Km之间的一致性差. 结论 RTVue FD-OCT评估角膜曲率和CCT具有很好的重复性；RTVue FD-OCT获得的SimK比角膜地形图仪略大；RTVue FD-OCT获得的Rposterior/Ranterior比Gullstrand模型眼小,可能为建立更准确的标准化模型眼提供依据.
    배경 각막각삼수(여곡솔、후도등)대우진단각막원성질병、각막접촉경적험배급각막굴광수술지관중요. 목적 연구RTVue부리협광학상간단층소묘의(FD-OCT)평고각막각삼수적중복성여준학성,위FD-OCT적림상응용제공삼고의거.방법 본연구위전첨성연구.접수준분자격광각막원위마양술(LASIK)술전검사자43례77안,굴광도위-1.25～-10.00 D,산광도＜2 D.사용RTVue FD-OCT측량각막중앙3 mm직경범위내전표면곡솔반경Ranterior、후표면곡솔반경Rposterior、각막후전표면곡솔반경지비Rposterior/Ranterior、중앙각막후도(CCT)、통과후투경공식획득각막총굴광력Knet、모의각막굴광력SimK、각막전표면중앙직경3 mm범위내굴광력Kanterior、각막후표면중앙직경3 mm범위내굴광력Kposterior,급기우Placido배원리적Topolyzer획득적각막굴광력Km,매지수시안련속측량3차.채용변이계수(CV)、Cronbach Alpha계수급조내상관계수(ICC)평고중복성,중복측량방차분석비교SimK여Knet、Knet여Km、SimK여Km지간적차이성,Pearson상관분석SimK여Knet、Knet여Km、SimK여Km지간적상관성,Bland-Altman분석SimK여Knet、Knet여Km、SimK여Km지간적일치성. 결과 Ranterior、Rposterior、Rposterior／Ranteror、Kanterior、Kposterior、SimK、Knet화CCT분별위(7.691±0.302) mm、(6.532±0.276) mm、0.849±0.014、(48.97±1.92)D、(-6.13±0.26)D、(43.95±1.72)D、(42.95±1.68)D화(545.20±35.04)μm,각삼수적CV균＜1％,Cronbach Alpha계수균＞0.9；Rposterior/Ranterior적ICC위0.802,기여삼수ICC균＞0.9.SimK비Km대(0.27±0.34)D,Knet비Km소(0.73±0.37)D,SimK비Knet대(1.01±0.11)D,차이균유통계학의의(P＜0.001).SimK여Km、Knet여Km、SimK여Knet균정정상관(r=0.981、0.976、0.998,P＜0.001).Bland-Altman분석현시,SimK、Knet、Km지간적일치성차. 결론 RTVue FD-OCT평고각막곡솔화CCT구유흔호적중복성；RTVue FD-OCT획득적SimK비각막지형도의략대；RTVue FD-OCT획득적Rposterior/Ranterior비Gullstrand모형안소,가능위건립경준학적표준화모형안제공의거.
    Background Corneal parameters (such as curvature,thickness,etc) are essential to the diagnosis of corneal related diseases,contact lenses fitting and corneal refractive surgery.Objective The aim of this study was to assess the repeatability and accuracy of corneal parameters obtained by RTVue Fourier-domain optical coherence topography (FD-OCT).Methods In this prospective study,77 eyes of 43 subjects with the refraction from-1.25 D to-10.00 D and astigmatism ＜2 D were enrolled in keratorefractive surgery center,Eye Hospital of Wenzhou Medical College.The anterior and posterior corneal curvature in 3 mm central zone (Ranterior and Rposterior),the ratio of posterior and anterior curvature (Rposterior/Ranterior),corneal central thickness (CCT),total corneal power(Knet),the simulated corneal power (Sim K),the anterior and posterior corneal power (Kanterior,Kposterior)were measured by FD-OCT.Corneal power (Km) was obtained by Topolyzer topography based on Placido ring.Three consecutive scans were acquired in every tested eye.Repeatability of FD-OCT measurement was assessed using the coefficient of variation CV),Cronbach Alpha and intra-class correlation coefficient (ICC).Repeated measure ANOVA was used to analyze the differences among SimK,Knet and Km.Pearson correlation analysis was used to analysis the correlation between SimK and K Knet and Km,SimK and Km.The agreement between Sim K and K Knet and Km,SimK and Km was assessed by Bland-Altman plots analysis.All the subjects understood the purpose of this investigation and written informed consent was obtained prior to the medical examination.Results The Ranterior,Rposterior,Rposterior/Ranterior,Kanterior,Kposterior,Sim K,Knet and CCT were (7.691 ±0.302) mm,(6.532±0.276) mm,0.849±0.014,(48.97±1.92)D,(-6.13±0.26)D,(43.95±1.72) D,(42.95±1.68) D and (545.20± 35.04) μm,respectively.The CV of all parameters was less than 1％.The Cronbach Alpha and ICC were both more than 0.9 except 0.802(ICC)of the Rposterior/Ranterior.SimK was (0.27±0.34) D higher than Km,and Knet was (0.73±0.37) D lower than Km.SimK was (1.01 ±0.11) D higher than K and all the differences showed a statistical significance (P＜0.001).There were close positive correlations between SimK and Km,Knet and Km,SimK and Knet(all r ≥ 0.976,P＜0.001).The Bland-Altman analysis showed a poor agreement between SimK and Km,Knet and Km,SimK and Knet.Conclusions The RTVue FD-OCT measuring corneal curvature and CCT performes good repeatability.The Sim K obtained by RTVue FD-OCT is slightly greater than that obtained by corneal topography,and the Rposterior/Ranterior obtained by RTVue FD-OCT is slightly lower than that from Gullstrand model eye.These results offer a basis for establishing a more accurate standardized model eye.
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