中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2014年
6期
546-550
,共5页
徐洋涛%刘泉%杜嗣河%秦嘉敏%刘杏%王丹阳%刘曼丽
徐洋濤%劉泉%杜嗣河%秦嘉敏%劉杏%王丹暘%劉曼麗
서양도%류천%두사하%진가민%류행%왕단양%류만려
体层摄影术%光学相干断层扫描%生物测量%黄斑中心凹下脉膜厚度%屈光不正,近视,远视
體層攝影術%光學相榦斷層掃描%生物測量%黃斑中心凹下脈膜厚度%屈光不正,近視,遠視
체층섭영술%광학상간단층소묘%생물측량%황반중심요하맥막후도%굴광불정,근시,원시
Tomography%Optical coherence tomography%Biomeasurement%Subfoveal choroidal thickness%Ametropia,myopia,hyperopia
背景 脉络膜厚度与屈光不正有一定的联系,研究两者之间的关系对于屈光不正发病机制的研究有重要意义. 目的 探讨黄斑中心凹下脉络膜厚度(SFCT)与屈光度的关联性.方法 采用回顾性系列病例观察研究.收集2012年6-8月在中山大学中山眼科中心就诊的屈光参差患者40例,按年龄分为6 ～13岁组和14 ～21岁组.巩膜在13岁基本发育完全,巩膜的发育对脉络膜厚度有较大的关联,因此分2组观察不同年龄段的脉络膜厚度与屈光度的关系.常规用EDTRS视力表进行视力测量、裂隙灯显微镜及直接检眼镜检查后,快速扩瞳,再进行主观验光、客观验光.应用EDI SD-OCT测量SFCT,在EDI模式下于眼底后极部进行图像采集.应用Lenstar 900型眼轴测量仪进行眼轴长度测量.采用成组设计t检验对不同性质屈光状态下SFCT的差异进行比较,采用Pearson直线相关分析和线性回归法分析SFCT与屈光度的关系. 结果 所有患者的SFCT均值为(307.82±88.47) μm,近视眼平均SFCT为(270.60±70.57) μm,明显低于远视眼的(376.95±76.59) μm,近视眼与远视眼间SFCT的差异有统计学意义(t=6.240,P=0.000).在6～13岁组,SFCT与屈光度间的回归系数为18.60,回归方程为Y=18.60X +310.79(r=0.345,F=21.110,P=0.000);SFCT与眼轴长度之间的回归系数为-31.76,回归方程Y=-31.76X+1 039.97(r=0.262,F =17.320,P=0.000).14 ～21岁组,SFCT与屈光度之间的回归系数为23.38,回归方程Y=23.38X+353.17(r=0.430,F=27.210,P=0.000);SFCT与眼轴长度之间的回归系数为-35.82,回归方程为Y=-35.82X+1 132.75(r=0.237,F=15.650,P=0.000).结论 SFCT与屈光度呈正相关,屈光度越偏向正值,SFCT值越大;而屈光度向负值增加-1D,SFCT则减少约20 μm.眼轴越长,SFCT值越下降.
揹景 脈絡膜厚度與屈光不正有一定的聯繫,研究兩者之間的關繫對于屈光不正髮病機製的研究有重要意義. 目的 探討黃斑中心凹下脈絡膜厚度(SFCT)與屈光度的關聯性.方法 採用迴顧性繫列病例觀察研究.收集2012年6-8月在中山大學中山眼科中心就診的屈光參差患者40例,按年齡分為6 ～13歲組和14 ～21歲組.鞏膜在13歲基本髮育完全,鞏膜的髮育對脈絡膜厚度有較大的關聯,因此分2組觀察不同年齡段的脈絡膜厚度與屈光度的關繫.常規用EDTRS視力錶進行視力測量、裂隙燈顯微鏡及直接檢眼鏡檢查後,快速擴瞳,再進行主觀驗光、客觀驗光.應用EDI SD-OCT測量SFCT,在EDI模式下于眼底後極部進行圖像採集.應用Lenstar 900型眼軸測量儀進行眼軸長度測量.採用成組設計t檢驗對不同性質屈光狀態下SFCT的差異進行比較,採用Pearson直線相關分析和線性迴歸法分析SFCT與屈光度的關繫. 結果 所有患者的SFCT均值為(307.82±88.47) μm,近視眼平均SFCT為(270.60±70.57) μm,明顯低于遠視眼的(376.95±76.59) μm,近視眼與遠視眼間SFCT的差異有統計學意義(t=6.240,P=0.000).在6～13歲組,SFCT與屈光度間的迴歸繫數為18.60,迴歸方程為Y=18.60X +310.79(r=0.345,F=21.110,P=0.000);SFCT與眼軸長度之間的迴歸繫數為-31.76,迴歸方程Y=-31.76X+1 039.97(r=0.262,F =17.320,P=0.000).14 ～21歲組,SFCT與屈光度之間的迴歸繫數為23.38,迴歸方程Y=23.38X+353.17(r=0.430,F=27.210,P=0.000);SFCT與眼軸長度之間的迴歸繫數為-35.82,迴歸方程為Y=-35.82X+1 132.75(r=0.237,F=15.650,P=0.000).結論 SFCT與屈光度呈正相關,屈光度越偏嚮正值,SFCT值越大;而屈光度嚮負值增加-1D,SFCT則減少約20 μm.眼軸越長,SFCT值越下降.
배경 맥락막후도여굴광불정유일정적련계,연구량자지간적관계대우굴광불정발병궤제적연구유중요의의. 목적 탐토황반중심요하맥락막후도(SFCT)여굴광도적관련성.방법 채용회고성계렬병례관찰연구.수집2012년6-8월재중산대학중산안과중심취진적굴광삼차환자40례,안년령분위6 ～13세조화14 ～21세조.공막재13세기본발육완전,공막적발육대맥락막후도유교대적관련,인차분2조관찰불동년령단적맥락막후도여굴광도적관계.상규용EDTRS시력표진행시력측량、렬극등현미경급직접검안경검사후,쾌속확동,재진행주관험광、객관험광.응용EDI SD-OCT측량SFCT,재EDI모식하우안저후겁부진행도상채집.응용Lenstar 900형안축측량의진행안축장도측량.채용성조설계t검험대불동성질굴광상태하SFCT적차이진행비교,채용Pearson직선상관분석화선성회귀법분석SFCT여굴광도적관계. 결과 소유환자적SFCT균치위(307.82±88.47) μm,근시안평균SFCT위(270.60±70.57) μm,명현저우원시안적(376.95±76.59) μm,근시안여원시안간SFCT적차이유통계학의의(t=6.240,P=0.000).재6～13세조,SFCT여굴광도간적회귀계수위18.60,회귀방정위Y=18.60X +310.79(r=0.345,F=21.110,P=0.000);SFCT여안축장도지간적회귀계수위-31.76,회귀방정Y=-31.76X+1 039.97(r=0.262,F =17.320,P=0.000).14 ～21세조,SFCT여굴광도지간적회귀계수위23.38,회귀방정Y=23.38X+353.17(r=0.430,F=27.210,P=0.000);SFCT여안축장도지간적회귀계수위-35.82,회귀방정위Y=-35.82X+1 132.75(r=0.237,F=15.650,P=0.000).결론 SFCT여굴광도정정상관,굴광도월편향정치,SFCT치월대;이굴광도향부치증가-1D,SFCT칙감소약20 μm.안축월장,SFCT치월하강.
Background Choroidal thickness is closely associated with ametropia,and to study the influence of subfoveal choroidal thickness (SFCT) on refraction is very important for understanding the mechanism of refractive error more clearly.Objective This study was to investigate the relationship between SFCT and refraction.Methods A retrospective serial cases analysis was performed.Forty anisometrope patients were recruited in Zhongshan Ophthalmic Center from June 2012 to August 2012.The subjects were divided into 6-13 years group and 14-21 years group.Vision acuity was tested by the EDTRS visual acuity chart and ocular anterior segment was examined under the slit lamp microscope,and the fundus examination was performed by direct ophthalmoscope.Subjective and objective optometry was performed after pupils were dilated.EDI OCT was used to illuminate choroidal image.Ocular axial length (AL) was obtained by Lenstar 900.The difference in SFCT between myopic eyes and hyperopic eyes was compared using Student t test,and the correlations between SFCT and refraction were analyzed by Pearson linear analysis and linear regression analysis.Results The average SFCT was (307.82±88.47) μm in all the tested eyes,and the SFCT of myopic eyes and hyperopic eyes was (270.60±70.57) μm and (376.95±76.59) μm,respectively,with a significant difference between them (P =0.000).In the 6-13 years group,positive correlations were found between SFCT and diopters with the regression coefficient 18.60 and regression equation Y =18.60X +310.79 (r=0.345,F=21.110,P=0.000) as well as between SFCT and AL with the regression coefficient -31.76 and regression equation Y =-31.76X+1 039.97 (r=0.262,F=17.320,P=0.000).In the 14-21 years group,SFCT showed positive correlation with diopters,with the regression coefficient 23.38 and regression equation Y=23.38X+353.17 (r =0.430,F =27.210,P =0.000) and negative correlation with AL,with the regression coefficient-35.82 and regression equation Y =-35.82X+1 132.75 (r=0.237,F=15.650,P=0.000).Conclusions SFCT seems to be positive correlated with diopter.When the diopter shifts toward positive value,SFCT value increases,and whenever diopter increases-1 D,SFCT decreases 20 μm approximately.SFCT decreases with the increase of AL.
