中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2012年
9期
546-550
,共5页
刘林%鲍慧婧%杨丽萍%黄辉%陈少肜%邹俊
劉林%鮑慧婧%楊麗萍%黃輝%陳少肜%鄒俊
류림%포혜청%양려평%황휘%진소융%추준
近视%神经纤维层%体层摄影术,光学相干
近視%神經纖維層%體層攝影術,光學相榦
근시%신경섬유층%체층섭영술,광학상간
Myopic%Retinal nerve fiber layer thickness%Tomography,optical coherence
目的 探讨青年近视患者的神经纤维层(RNFL)厚度分布特性及其影响因素.方法 横断面研究.选取准分子激光角膜屈光手术前的青年近视患者162例(162眼),平均年龄(27.0±4.6)岁,等效球镜度-0.75～-11.00 D,平均(-4.98±2.64)D.其中,低度近视组54例,平均等效球镜度为(-2.27±0.64)D;中度近视组55例,平均等效球镜度为(-4.54±0.79)D；高度组53例,平均等效球镜度为(-8.19±1.51)D.采用光学相干断层扫描(OCT)仪检查视盘周围神经纤维层厚度,用偏相关分析RNFL厚度与患者年龄、性别、等效球镜度、眼轴、角膜中央厚度及角膜曲率的相关性.结果 本组入选患者视盘周围平均RNFL厚度:全周为(103.6±9.5)μm,上方为(128.7±16.8)μm,鼻侧为(67.8± 16.5)μm,下方为(125.9± 17.2)μm,颞侧为(91.9±16.9)μm.各RNFL厚度参数与年龄、性别、角膜曲率、中央角膜厚度无相关性,全周、上方、鼻侧、下方的平均RNFL厚度与眼轴呈负相关(r=-0.379、-0.297、-0.180 、-0.291,P＜0.05),颞侧的平均RNFL厚度则与眼轴无相关性,鼻侧、下方的平均RNFL厚度与等效球镜度呈负相关(r=-0.233、-0.163,P＜0.05),颞侧平均RNFL厚度与等效球镜度则呈正相关(r=0.159,P＜0.05).结论 青年近视患者视盘周围平均RNFL厚度上方＞下方＞颞侧＞鼻侧,全周、鼻侧、上方、下方平均RNFL厚度随眼轴的增长而变薄,下方和鼻侧RNFL厚度随等效球镜度增加而变薄,颞侧平均RNFL厚度随着等效球镜度增加而增厚.
目的 探討青年近視患者的神經纖維層(RNFL)厚度分佈特性及其影響因素.方法 橫斷麵研究.選取準分子激光角膜屈光手術前的青年近視患者162例(162眼),平均年齡(27.0±4.6)歲,等效毬鏡度-0.75～-11.00 D,平均(-4.98±2.64)D.其中,低度近視組54例,平均等效毬鏡度為(-2.27±0.64)D;中度近視組55例,平均等效毬鏡度為(-4.54±0.79)D；高度組53例,平均等效毬鏡度為(-8.19±1.51)D.採用光學相榦斷層掃描(OCT)儀檢查視盤週圍神經纖維層厚度,用偏相關分析RNFL厚度與患者年齡、性彆、等效毬鏡度、眼軸、角膜中央厚度及角膜麯率的相關性.結果 本組入選患者視盤週圍平均RNFL厚度:全週為(103.6±9.5)μm,上方為(128.7±16.8)μm,鼻側為(67.8± 16.5)μm,下方為(125.9± 17.2)μm,顳側為(91.9±16.9)μm.各RNFL厚度參數與年齡、性彆、角膜麯率、中央角膜厚度無相關性,全週、上方、鼻側、下方的平均RNFL厚度與眼軸呈負相關(r=-0.379、-0.297、-0.180 、-0.291,P＜0.05),顳側的平均RNFL厚度則與眼軸無相關性,鼻側、下方的平均RNFL厚度與等效毬鏡度呈負相關(r=-0.233、-0.163,P＜0.05),顳側平均RNFL厚度與等效毬鏡度則呈正相關(r=0.159,P＜0.05).結論 青年近視患者視盤週圍平均RNFL厚度上方＞下方＞顳側＞鼻側,全週、鼻側、上方、下方平均RNFL厚度隨眼軸的增長而變薄,下方和鼻側RNFL厚度隨等效毬鏡度增加而變薄,顳側平均RNFL厚度隨著等效毬鏡度增加而增厚.
목적 탐토청년근시환자적신경섬유층(RNFL)후도분포특성급기영향인소.방법 횡단면연구.선취준분자격광각막굴광수술전적청년근시환자162례(162안),평균년령(27.0±4.6)세,등효구경도-0.75～-11.00 D,평균(-4.98±2.64)D.기중,저도근시조54례,평균등효구경도위(-2.27±0.64)D;중도근시조55례,평균등효구경도위(-4.54±0.79)D；고도조53례,평균등효구경도위(-8.19±1.51)D.채용광학상간단층소묘(OCT)의검사시반주위신경섬유층후도,용편상관분석RNFL후도여환자년령、성별、등효구경도、안축、각막중앙후도급각막곡솔적상관성.결과 본조입선환자시반주위평균RNFL후도:전주위(103.6±9.5)μm,상방위(128.7±16.8)μm,비측위(67.8± 16.5)μm,하방위(125.9± 17.2)μm,섭측위(91.9±16.9)μm.각RNFL후도삼수여년령、성별、각막곡솔、중앙각막후도무상관성,전주、상방、비측、하방적평균RNFL후도여안축정부상관(r=-0.379、-0.297、-0.180 、-0.291,P＜0.05),섭측적평균RNFL후도칙여안축무상관성,비측、하방적평균RNFL후도여등효구경도정부상관(r=-0.233、-0.163,P＜0.05),섭측평균RNFL후도여등효구경도칙정정상관(r=0.159,P＜0.05).결론 청년근시환자시반주위평균RNFL후도상방＞하방＞섭측＞비측,전주、비측、상방、하방평균RNFL후도수안축적증장이변박,하방화비측RNFL후도수등효구경도증가이변박,섭측평균RNFL후도수착등효구경도증가이증후.
Objective To evaluate the topographic profile and influential factors of peripapillary retinal nerve fiber layer (RNFL) thickness in young myopia.Methods It was a cross-sectional study.One hundred and sixty-two eyes of 162 consecutive refractive surgery candidates were included in this study.The mean age of the subjects was 27.0±4.6 years old,the average spherical equivalent (SE) was-4.98±2.64 D with a range of-0.75 D to-11.00 D,of 54 eyes were low myopia with the mean SE was-2.27±0.64 D,55 eyes were moderate myopia with the average SE was-4.54±0.79 D,53 eyes were high myopia with the mean SE was-8.19±1.51 D.All subjects underwent ophthalmic examination and the imaging with the Stratus optical coherence tomography (Stratus OCT).Data were analyzed using a partial correlation.Results The global RNFL thickness was 103.6±9.5 μm,the RNFL thickness of the superior quadrant was 128.7±16.8 μm,the RNFL thickness of the nasal quadrant was 67.8±16.5 μm,the RNFL thickness of the inferior quadrant was 125.9±17.2 μm,the RNFL thickness of the temporal quadrant was 91.9±16.9 μm.No statistically significant associations between the parameters of RNFL thickness and age,gender,corneal curvature,central corneal thickness (CCT),negative correlation between the axial length and RNFL thickness of the global,superior quadrant,the nasal quadrant,the inferior quadrant (r=-0.379,-0.297,-0.180,-0.291,All P value ＜0.05),while no statistically significant associations between the RNFL thickness of temporal and the axial length.The partial correlation coefficient between the RNFL thickness of the superior quadrant,the nasal quadrant,the inferior quadrant,the temporal quadrant and SE was r=0.003 (P=0.968),r=-0.233 (P=0.003),r=-0.163 (P=0.039),r=0.159 (P=0.045),respectively.Conclusion The topographic profile of peripapillary RNFL thickness is the superior quadrant ＞the inferior quadrant ＞the temporal quadrant ＞the nasal quadrant in these young myopia.The global RNFL thickness and the RNFL thickness of the nasal quadrant decreased with the axial length,also in the superior quadrant and the inferior quadrant.The RNFL thickness of the nasal and the superior quadrant are decrease with the SE,while the RNFL thickness of the temporal quadrant is increased.
