CAJ | 학술논문

人类β-防御素(hBDs)存在于多种器官组织的黏膜上皮细胞内,不仅具有广谱抗细菌、真菌、包膜病毒的活性,还能调节免疫应答和炎症反应,已成为近年来研究的热点.眼球作为一个暴露于体表的器官,易受到各种病原微生物的侵害,造成感染,进而影响视功能.在过去的十余年时间里,许多研究已经证明眼球及其附属器也像人体内的其他组织一样能够表达和分泌β-防御素,其在眼部的防御保护机制中发挥着重要作用.现就β-防御素的生物学活性、在眼部的表达、与一些眼表疾病的关系及其在眼科的应用前景作一综述.
인류β-방어소(hBDs)존재우다충기관조직적점막상피세포내,불부구유엄보항세균、진균、포막병독적활성,환능조절면역응답화염증반응,이성위근년래연구적열점.안구작위일개폭로우체표적기관,역수도각충병원미생물적침해,조성감염,진이영향시공능.재과거적십여년시간리,허다연구이경증명안구급기부속기야상인체내적기타조직일양능구표체화분비β-방어소,기재안부적방어보호궤제중발휘착중요작용.현취β-방어소적생물학활성、재안부적표체、여일사안표질병적관계급기재안과적응용전경작일종술.
Human beta defensins are widely expressed in the mucosal epithelial cells of organs and tissues.Beta defensins not only exhibit broad-spectrum antimicrobial activity against bacteria,fungi and enveloped virus,but also regulate immune response and inflammation.This research area has become a hot topic in recent years.The eyeball,as an exposed organ,is susceptible to all kinds of pathogens,resulting in infections and visual impairment.Over the past decade,several studies have demonstrated that,like many tissues in the body,the eye and its associated structures secrete and express beta defensins,which play an important role in the defense mechanism of the eye.In this review,we focus on the biological activities of beta defensins,their expression and distribution in the eye,their roles and potential applications in eye diseases.