中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
33期
1-3
,共3页
甲状腺肿瘤%Kangai-1蛋白质%免疫组织化学
甲狀腺腫瘤%Kangai-1蛋白質%免疫組織化學
갑상선종류%Kangai-1단백질%면역조직화학
Thyroid neoplasms%Kangai-1 protein%Immunohistochemistry
目的 探讨KAI1蛋白在甲状腺乳头状癌(PTC)和滤泡癌组织中表达及其在PTC浸润和转移中的作用.方法 回顾性分析2006年1月至2009年8月收治的58例PTC患者(PTC组)、17例甲状腺滤泡癌患者(滤泡癌组)和30例甲状腺良性肿瘤患者(对照组)的临床资料,采用免疫组织化学方法测定PTC组织、甲状腺滤泡癌组织和甲状腺良性肿瘤组织中KAI1蛋白的表达.结果 KAI1蛋白在PTC组阳性表达率为48.3％(28/58),滤泡癌组为47.1％(8/17),对照组为86.7％(26/30),PTC组、滤泡癌组与对照组比较差异有统计学意义(P＜0.01),而PTC组与滤泡癌组比较差异无统计学意义(P＞0.05).PTC组KAI1蛋白表达在患者性别、年龄及原发病灶直径之间比较差异无统计学意义(P＞0.05).KAI1蛋白在肿瘤的TNM分期Ⅰ期的阳性表达率为88.9％(8/9)、Ⅱ期为60.9％(14/23)、Ⅲ～Ⅳ期为23.1％(6/26),不同TNM分期的KAI1蛋白阳性表达率比较差异有统计学意义(P＜0.01)；KAI1蛋白在有淋巴结转移的PTC组织中和无淋巴结转移的PTC组织中的阳性表达率分别为32.3％(10/31)和66.7％(18/27),两者比较差异有统计学意义(P＜0.05).结论 KAI1蛋白表达可反映PTC的转移能力以及临床演进程度,KAI1蛋白可能对PTC的浸润和转移有抑制作用.
目的 探討KAI1蛋白在甲狀腺乳頭狀癌(PTC)和濾泡癌組織中錶達及其在PTC浸潤和轉移中的作用.方法 迴顧性分析2006年1月至2009年8月收治的58例PTC患者(PTC組)、17例甲狀腺濾泡癌患者(濾泡癌組)和30例甲狀腺良性腫瘤患者(對照組)的臨床資料,採用免疫組織化學方法測定PTC組織、甲狀腺濾泡癌組織和甲狀腺良性腫瘤組織中KAI1蛋白的錶達.結果 KAI1蛋白在PTC組暘性錶達率為48.3％(28/58),濾泡癌組為47.1％(8/17),對照組為86.7％(26/30),PTC組、濾泡癌組與對照組比較差異有統計學意義(P＜0.01),而PTC組與濾泡癌組比較差異無統計學意義(P＞0.05).PTC組KAI1蛋白錶達在患者性彆、年齡及原髮病竈直徑之間比較差異無統計學意義(P＞0.05).KAI1蛋白在腫瘤的TNM分期Ⅰ期的暘性錶達率為88.9％(8/9)、Ⅱ期為60.9％(14/23)、Ⅲ～Ⅳ期為23.1％(6/26),不同TNM分期的KAI1蛋白暘性錶達率比較差異有統計學意義(P＜0.01)；KAI1蛋白在有淋巴結轉移的PTC組織中和無淋巴結轉移的PTC組織中的暘性錶達率分彆為32.3％(10/31)和66.7％(18/27),兩者比較差異有統計學意義(P＜0.05).結論 KAI1蛋白錶達可反映PTC的轉移能力以及臨床縯進程度,KAI1蛋白可能對PTC的浸潤和轉移有抑製作用.
목적 탐토KAI1단백재갑상선유두상암(PTC)화려포암조직중표체급기재PTC침윤화전이중적작용.방법 회고성분석2006년1월지2009년8월수치적58례PTC환자(PTC조)、17례갑상선려포암환자(려포암조)화30례갑상선량성종류환자(대조조)적림상자료,채용면역조직화학방법측정PTC조직、갑상선려포암조직화갑상선량성종류조직중KAI1단백적표체.결과 KAI1단백재PTC조양성표체솔위48.3％(28/58),려포암조위47.1％(8/17),대조조위86.7％(26/30),PTC조、려포암조여대조조비교차이유통계학의의(P＜0.01),이PTC조여려포암조비교차이무통계학의의(P＞0.05).PTC조KAI1단백표체재환자성별、년령급원발병조직경지간비교차이무통계학의의(P＞0.05).KAI1단백재종류적TNM분기Ⅰ기적양성표체솔위88.9％(8/9)、Ⅱ기위60.9％(14/23)、Ⅲ～Ⅳ기위23.1％(6/26),불동TNM분기적KAI1단백양성표체솔비교차이유통계학의의(P＜0.01)；KAI1단백재유림파결전이적PTC조직중화무림파결전이적PTC조직중적양성표체솔분별위32.3％(10/31)화66.7％(18/27),량자비교차이유통계학의의(P＜0.05).결론 KAI1단백표체가반영PTC적전이능력이급림상연진정도,KAI1단백가능대PTC적침윤화전이유억제작용.
Objective To investigate the expression of KAI1 protein in tissues of papillary thyroid cancer (PTC) and follicular thyroid cancer,and the effect of KAI1 protein in invasion and metastasis of PTC.Methods The clinical data of 58 patients with PTC (PTC group),17 patients with follicular thyroid cancer (follicular cancer group) and 30 patients with benign thyroid tumor (control group) were retrospectively analyzed from January 2006 to August 2009.The expression of KAI1 protein in PTC tissues,follicular thyroid cancer tissues and benign thyroid tumor tiasues were detected by immunohistochemistry method.Results The positive expression rate of KAI1 protein in PTC group was 48.3％(28/58),in follicular cancer group was 47.1％(8/17),in control group was 86.7 ％(26/30).There was significant difference between PTC group,follicular cancer group and control group (P＜ 0.01).There was no significant difference between PTC group and follicular cancer group (P ＞ 0.05).There was no significant difference in the positive expression rate of KAI1 protein of PTC tissues among the different sex,age and size of the primary lesion (P＞ 0.05).The positive expression rate of KAI1 protein in the TNM Ⅰ was 88.9％(8/9),the TNM Ⅱ was 60.9％(14/23)and the TNM Ⅲ-Ⅳ was 23.1％ (6/26),there was significant difference in the positive expression rate of KAI1 protein among the different TNM stage (P ＜ 0.01).The positive expression rate of KAI1 protein in the lymph node metastasis patients was 32.3％ (10/31),the non-lymph node metastasis patients was 66.7％ (18/27),there was significant difference (P ＜ 0.05).Conclusion The expression of KAI1 protein may reflect the PTC metastasis and the clinical evolution of tumors,the KAI1 protein may inhibit the invasion and metastasis of PTC.
