CAJ | 학술논문

目的探讨医用三氧大自血疗法对颈动脉斑块的临床疗效以及对炎性因子的影响.方法选择2010年10月至201 1年12月住院行颈动脉彩超检查提示颈动脉软斑或(和)混合斑的患者90例,按照随机数字表法分为三氧组、阿托伐他汀组和饮食组,每组30例.饮食组给予低脂饮食控制；阿托伐他汀组给予阿托伐他汀20 mg,每天1次口服；三氧组给予医用三氧大自血疗法,每周2次,1个疗程为8次,共2个疗程,中间间隔3个月.检测双侧颈动脉内膜-中层厚度,斑块个数、面积、性质、纤维帽特性及超敏C反应蛋白(hs-CRP)等指标.比较三组治疗前后的颈动脉斑块Crouse积分、hs-CRP的变化.结果治疗前阿托伐他汀组、三氧组斑块Crouse积分、hs-CRP分别为(2.34±0.97)分、(4.9±4.0) mg/L和(2.35±0.63)分、(4.8±3.7) mg/L,治疗后分别为(1.80±0.59)分、(3.3±2.2) mg/L和(1.92±0.47)分、(3.4±2.0) mg/L,治疗后较治疗前明显下降,差异有统计学意义(P＜0.05).而饮食组治疗前后的斑块Crouse积分、hs-CRP的变化差异无统计学意义(P＞0.05).治疗后,阿托伐他汀组、三氧组与饮食组比较,斑块Crouse积分、hs-CRP明显下降,差异有统计学意义(P＜0.05)；而阿托伐他汀组与三氧组之间斑块Crouse积分、hs-CRP比较差异无统计学意义(P＞0.05).结论医用三氧大自血疗法可调低hs-CRP水平,达到抗炎抗动脉硬化,从而逆转颈动脉斑块的作用,疗效与阿托伐他汀相当,明显优于饮食控制,可作为颈动脉斑块治疗的新途径.
목적 탐토의용삼양대자혈요법대경동맥반괴적림상료효이급대염성인자적영향.방법 선택2010년10월지201 1년12월주원행경동맥채초검사제시경동맥연반혹(화)혼합반적환자90례,안조수궤수자표법분위삼양조、아탁벌타정조화음식조,매조30례.음식조급여저지음식공제；아탁벌타정조급여아탁벌타정20 mg,매천1차구복；삼양조급여의용삼양대자혈요법,매주2차,1개료정위8차,공2개료정,중간간격3개월.검측쌍측경동맥내막-중층후도,반괴개수、면적、성질、섬유모특성급초민C반응단백(hs-CRP)등지표.비교삼조치료전후적경동맥반괴Crouse적분、hs-CRP적변화.결과 치료전아탁벌타정조、삼양조반괴Crouse적분、hs-CRP분별위(2.34±0.97)분、(4.9±4.0) mg/L화(2.35±0.63)분、(4.8±3.7) mg/L,치료후분별위(1.80±0.59)분、(3.3±2.2) mg/L화(1.92±0.47)분、(3.4±2.0) mg/L,치료후교치료전명현하강,차이유통계학의의(P＜0.05).이음식조치료전후적반괴Crouse적분、hs-CRP적변화차이무통계학의의(P＞0.05).치료후,아탁벌타정조、삼양조여음식조비교,반괴Crouse적분、hs-CRP명현하강,차이유통계학의의(P＜0.05)；이아탁벌타정조여삼양조지간반괴Crouse적분、hs-CRP비교차이무통계학의의(P＞0.05).결론 의용삼양대자혈요법가조저hs-CRP수평,체도항염항동맥경화,종이역전경동맥반괴적작용,료효여아탁벌타정상당,명현우우음식공제,가작위경동맥반괴치료적신도경.
Objective To investigate the clinical effect of medical trioxyen major autohemotherapy (MAH) on carotid plaque and its influence on inflammatory factor.Methods Ninety patients with soft carotid plaque or (and) mixture sample diagnosed by the examination of carotid color ultrasonography from October 2010 to December 2011 were divided into three groups by random digits table method with 30 cases each.The diet group was given low-fat diet; the artorvastatin group was given 20 mg artorvastatin once a day;while the trioxyen group was treated with medical trioxyen MAH.This treatment contained two courses of treatment with an interval of three months,eight times in each course and twice a week.The carotid intimamedia thickness and such indexes as the number,size,characteristics,fibrous cap and high sensitivity C-reactive protein (hs-CRP) of the plaque etc were detected.The changes of the plaque Crouse score and hs-CRP before and after treatment among three groups were compared.Results Before treatment,the plaque Crouse score of the artorvastatin group,trioxyen group and diet group was (2.34 ± 0.97),(2.35 ±0.63) and (2.34 ± 0.82) scores,respectively.While after treatment,it was (1.80 ± 0.59),(1.92 ± 0.47)and (2.29 ± 0.71) scores,respectively.Before treatment,the hs-CRP of the artorvastatin group,trioxyen group and diet group was (4.9 ± 4.0),(4.8 ± 3.7) and (4.8 ± 3.6) mg/L,respectively.While after treatment,it was (3.3 ± 2.2),(3.4 ± 2.0) and (4.6 ± 2.5) mg/L,respectively.There was significant difference in the plaque Crouse score and hs-CRP in the artorvastatin group and the trioxyen group before and after treatment (P ＜0.05);while there was no statistical significance in the diet group (P ＞0.05).After 6 months of treatment,a remarkable slide showed in the plaque Crouse score and hs-CRP among the artorvastatin group,the trioxyen group and the diet group (P ＜ 0.05).But there was no statistical significance in the plaque Crouse score and hs-CRP between the artorvastatin group and the trioxyen group (P ＞ 0.05).Conclusions The medical trioxyen MAH can be regarded as a new access to treat carotid plaque because it has the function of reducing hs-CRP levels anti-inflammation and anti-arteriosclerosis so as to reverse the effect of carotid plaque.It presents equivalent clinical effect to atorvastatin and is remarkably superior to that of the diet.