中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
1期
10-12
,共3页
脑梗塞%脂联素%瘦素%Fugl-Meyer评分
腦梗塞%脂聯素%瘦素%Fugl-Meyer評分
뇌경새%지련소%수소%Fugl-Meyer평분
Brain infarction%Adiponectin%Leptin%Fugl-Meyer score
目的 探讨急性脑梗死患者血清脂联素、瘦素水平对运动功能恢复的影响.方法 选取45例急性脑梗死患者作为研究组,选取30例健康体检者作为对照组.出院时采用Fugl-Meyer评分评定急性脑梗死患者的运动功能恢复情况.采用酶联免疫吸附试验法测定受试者血清脂联素、瘦素水平,分析研究组患者血清脂联素、瘦素水平与出院时运动功能恢复程度的相关性.结果 对照组血清脂联素水平为(13.78±4.25) mg/L,明显高于研究组的(6.35±3.18) mg/L,对照组血清瘦素水平为(6.48±1.26) μg/L,明显低于研究组的(20.35±2.59) μg/L,差异有统计学意义(P＜0.05).研究组不同Fugl-Meyer评分患者的血清脂联素、瘦素水平比较差异有统计学意义(P＜0.05).血清脂联素水平与Fugl-Meyer评分呈正相关(r=0.528,P＜ 0.05),血清瘦素水平与Fugl-Meyer评分呈负相关(r=-0.564,P＜ 0.05).血清脂联素水平与血清瘦素水平呈负相关(r=-0.427,P＜0.05).结论 脂联素、瘦素参与了急性脑梗死的发生、发展,且两者水平与患者运动功能恢复程度密切相关.
目的 探討急性腦梗死患者血清脂聯素、瘦素水平對運動功能恢複的影響.方法 選取45例急性腦梗死患者作為研究組,選取30例健康體檢者作為對照組.齣院時採用Fugl-Meyer評分評定急性腦梗死患者的運動功能恢複情況.採用酶聯免疫吸附試驗法測定受試者血清脂聯素、瘦素水平,分析研究組患者血清脂聯素、瘦素水平與齣院時運動功能恢複程度的相關性.結果 對照組血清脂聯素水平為(13.78±4.25) mg/L,明顯高于研究組的(6.35±3.18) mg/L,對照組血清瘦素水平為(6.48±1.26) μg/L,明顯低于研究組的(20.35±2.59) μg/L,差異有統計學意義(P＜0.05).研究組不同Fugl-Meyer評分患者的血清脂聯素、瘦素水平比較差異有統計學意義(P＜0.05).血清脂聯素水平與Fugl-Meyer評分呈正相關(r=0.528,P＜ 0.05),血清瘦素水平與Fugl-Meyer評分呈負相關(r=-0.564,P＜ 0.05).血清脂聯素水平與血清瘦素水平呈負相關(r=-0.427,P＜0.05).結論 脂聯素、瘦素參與瞭急性腦梗死的髮生、髮展,且兩者水平與患者運動功能恢複程度密切相關.
목적 탐토급성뇌경사환자혈청지련소、수소수평대운동공능회복적영향.방법 선취45례급성뇌경사환자작위연구조,선취30례건강체검자작위대조조.출원시채용Fugl-Meyer평분평정급성뇌경사환자적운동공능회복정황.채용매련면역흡부시험법측정수시자혈청지련소、수소수평,분석연구조환자혈청지련소、수소수평여출원시운동공능회복정도적상관성.결과 대조조혈청지련소수평위(13.78±4.25) mg/L,명현고우연구조적(6.35±3.18) mg/L,대조조혈청수소수평위(6.48±1.26) μg/L,명현저우연구조적(20.35±2.59) μg/L,차이유통계학의의(P＜0.05).연구조불동Fugl-Meyer평분환자적혈청지련소、수소수평비교차이유통계학의의(P＜0.05).혈청지련소수평여Fugl-Meyer평분정정상관(r=0.528,P＜ 0.05),혈청수소수평여Fugl-Meyer평분정부상관(r=-0.564,P＜ 0.05).혈청지련소수평여혈청수소수평정부상관(r=-0.427,P＜0.05).결론 지련소、수소삼여료급성뇌경사적발생、발전,차량자수평여환자운동공능회복정도밀절상관.
Objective To investigate the effects of serum adiponectin,leptin levels on motor functional outcome in the patients with acute cerebral infarction.Methods Forty-five patients with acute cerebral infarction and 30 healthy cases were selected as study group and control group.Motor functional outcome was evaluated by Fugl-Meyer score.Serum adiponectin and leptin levels were detected by enzyme linked immunosorbent assay.The correlation between serum adiponectin,leptin levels and motor functional outcome was assessed.Results Serum adiponectin level in control group [(13.78 ±4.25) mg/L] was higher than that in study group[(6.35 ± 3.18) mg/L],and there was significant difference between two groups (P ＜ 0.05).Serum leptin level in control group [(6.48 ± 1.26) μ g/L] was lower than that in study group [(20.35 ± 2.59) μg/L],and there was significant difference between two groups (P ＜0.05).There was significant difference in serum adiponectin and leptin levels among different Fugl-Meyer score in study group (P ＜ 0.05).Serum adiponectin level had positive correlation with Fugl-Meyer score (r =0.528,P ＜ 0.05).Serum leptin level had negative correlation with Fugl-Meyer score (r =-0.564,P＜ 0.05).There was negative correlation between serum adiponectin levels and serum leptin levels (r =-0.427,P ＜ 0.05).Conclusions Adiponectin and leptin is associated with pathogenesis of acute cerebral infarction.The correlation between serum adiponectin,leptin levels and motor functional outcome is close.
