中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
4期
3-5
,共3页
陈永前%王爱华%武艳红%朱保权
陳永前%王愛華%武豔紅%硃保權
진영전%왕애화%무염홍%주보권
危重病%L选择素%胃肠功能衰竭%整合素α4β7
危重病%L選擇素%胃腸功能衰竭%整閤素α4β7
위중병%L선택소%위장공능쇠갈%정합소α4β7
Critical illness%L-selectin%Gastrointestinal dysfunction%Integrin α 4 β 7
目的 探讨危重症患儿胃肠功能衰竭时整合素α4 β 7及L-选择素的表达及其与肠道黏膜免疫功能的关系.方法 选择危重症患儿48例,按有无胃肠功能衰竭分为非胃肠功能衰竭组(29例)及胃肠功能衰竭组(19例),另选择同期25例健康体检儿童作为对照组.应用流式细胞仪检测各组整合素α4β7和L-选择素的表达,并进行比较.结果 胃肠功能衰竭组整合素α4β7[(11.11±1.15)％]显著低于非胃肠功能衰竭组[(15.36±1.26)％]和对照组[(19.62±0.89)％](P＜0.05),非胃肠功能衰竭组整合素α4β7与对照组比较差异无统计学意义(P＞0.05).胃肠功能衰竭组L-选择素[(60.68±3.72)％]显著低于非胃肠功能衰竭组[(69.43±1.52)％]和对照组[(88.65±2.41)％],非胃肠功能衰竭组L-选择素显著低于对照组,差异均有统计学意义(P＜0.05).结论 整合素α4β7和L-选择素水平在危重症患儿发生胃肠功能衰竭的早期开始降低,且整合素α4β7在胃肠功能衰竭时降低更加明显.
目的 探討危重癥患兒胃腸功能衰竭時整閤素α4 β 7及L-選擇素的錶達及其與腸道黏膜免疫功能的關繫.方法 選擇危重癥患兒48例,按有無胃腸功能衰竭分為非胃腸功能衰竭組(29例)及胃腸功能衰竭組(19例),另選擇同期25例健康體檢兒童作為對照組.應用流式細胞儀檢測各組整閤素α4β7和L-選擇素的錶達,併進行比較.結果 胃腸功能衰竭組整閤素α4β7[(11.11±1.15)％]顯著低于非胃腸功能衰竭組[(15.36±1.26)％]和對照組[(19.62±0.89)％](P＜0.05),非胃腸功能衰竭組整閤素α4β7與對照組比較差異無統計學意義(P＞0.05).胃腸功能衰竭組L-選擇素[(60.68±3.72)％]顯著低于非胃腸功能衰竭組[(69.43±1.52)％]和對照組[(88.65±2.41)％],非胃腸功能衰竭組L-選擇素顯著低于對照組,差異均有統計學意義(P＜0.05).結論 整閤素α4β7和L-選擇素水平在危重癥患兒髮生胃腸功能衰竭的早期開始降低,且整閤素α4β7在胃腸功能衰竭時降低更加明顯.
목적 탐토위중증환인위장공능쇠갈시정합소α4 β 7급L-선택소적표체급기여장도점막면역공능적관계.방법 선택위중증환인48례,안유무위장공능쇠갈분위비위장공능쇠갈조(29례)급위장공능쇠갈조(19례),령선택동기25례건강체검인동작위대조조.응용류식세포의검측각조정합소α4β7화L-선택소적표체,병진행비교.결과 위장공능쇠갈조정합소α4β7[(11.11±1.15)％]현저저우비위장공능쇠갈조[(15.36±1.26)％]화대조조[(19.62±0.89)％](P＜0.05),비위장공능쇠갈조정합소α4β7여대조조비교차이무통계학의의(P＞0.05).위장공능쇠갈조L-선택소[(60.68±3.72)％]현저저우비위장공능쇠갈조[(69.43±1.52)％]화대조조[(88.65±2.41)％],비위장공능쇠갈조L-선택소현저저우대조조,차이균유통계학의의(P＜0.05).결론 정합소α4β7화L-선택소수평재위중증환인발생위장공능쇠갈적조기개시강저,차정합소α4β7재위장공능쇠갈시강저경가명현.
Objective To explore the changes ofintegrin α4β7 and L-selectin levels and the possible relationship between the changes and intestinal mucosal immune function in critical children with gastrointestinal dysfunction.Methods Forty-eight admitted critical children were divided into non-gastrointestinal dysfunction group (29 cases) and gastrointestinal dysfunction group (19 cases),and also compared with 25 healthy people (control group).The expression of integrin α 4β 7 and L-selectin was measured by flow cytometry.Results The expression of integrin α 4β 7 in gastrointestinal dysfunction group [(11.11 ± 1.15)％] was lower than that in non-gastrointestinal dysfunction group [(15.36 ± 1.26)％]and control group [(19.62 ±0.89)％] (P ＜0.05),but there was no significant difference between nongastrointestinal dysfunction group and control group(P ＞ 0.05).The expression of L-selectin in gastrointestinal dysfunction group [(60.68 ±3.72)％] was lower than that in non-gastrointestinal dysfunction group [(69.43 ± 1.52)％] and control group [(88.65 ± 2.41)％] (P ＜ 0.05),and there was significant difference between non-gastrointestinal dysfunction group and control group (P ＜ 0.05).Conclusion The expression of integrin α 4β 7 and L-selectin is decreased at the early stage of gastrointestinal dysfunction in critical childern,and integrin α 4 β 7 is decreased sharply.
