中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
24期
20-23
,共4页
代谢综合征X%妇科恶性肿瘤%胰岛素抵抗%临床特征
代謝綜閤徵X%婦科噁性腫瘤%胰島素牴抗%臨床特徵
대사종합정X%부과악성종류%이도소저항%림상특정
Metabolic Syndrome X%Gynecologic malignant neoplasms%Insulin resistance%Clinical characteristic
目的 探讨妇科恶性肿瘤与代谢综合征间的关系,指导妇科恶性肿瘤的预防和治疗.方法 选择妇科恶性肿瘤患者359例(研究组,其中卵巢癌142例,子宫内膜癌131例,子宫颈癌86例)和妇科良性肿瘤患者400例(对照组),比较两组患者一般情况、体格检查情况及空腹血糖、空腹胰岛素、稳态模型评估法胰岛素抵抗指数(HOMA-IR)、血脂等实验室指标,统计代谢综合征发生情况.结果 两组患者初潮年龄、发病年龄、孕次、产次比较差异均无统计学意义(P＞0.05).研究组收缩压、舒张压、体质指数、腹围、空腹血糖、空腹胰岛素、HOMA-IR、三酰甘油均明显高于对照组[(129±13) mm Hg(1 mm Hg=0.133 kPa)比(112±14) mm Hg、(87±11) mm Hg比(75±8)mm Hg、(26.7±2.8)kg/m2比(22.2±2.1)kg/m2、(88±7) cm比(76±9)cm、(6.5±2.9) mmol/L比(4.7±0.9) mmol/L、(9.2±4.7)mU/L比(5.2±3.0) mU/L、3.9±0.8比3.1±0.6、(3.21±1.96) mmol/L比(1.56±1.22) mmol/L],高密度脂蛋白胆固醇明显低于对照组[(1.25±0.51) mmol/L比(1.65±0.47) mmol/L],差异均有统计学意义(P＜0.05).研究组代谢综合征发生率为37.60％(135/359),其中卵巢癌患者发生率为37.32％(53/142),子宫内膜癌患者为43.51％(57/131),子宫颈癌患者为29.07％(25/86),均明显高于对照组的12.25％(49/400),差异有统计学意义(P＜0.05).结论 妇科恶性肿瘤患者代谢综合征发生率明显高于妇科良性肿瘤患者,妇科恶性肿瘤与代谢综合征间存在相互促进和影响的关系.重视代谢综合征在妇科恶性肿瘤发生和发展中可能产生的影响,并积极控制代谢综合征,对妇科恶性肿瘤的预防和治疗具有重要意义.
目的 探討婦科噁性腫瘤與代謝綜閤徵間的關繫,指導婦科噁性腫瘤的預防和治療.方法 選擇婦科噁性腫瘤患者359例(研究組,其中卵巢癌142例,子宮內膜癌131例,子宮頸癌86例)和婦科良性腫瘤患者400例(對照組),比較兩組患者一般情況、體格檢查情況及空腹血糖、空腹胰島素、穩態模型評估法胰島素牴抗指數(HOMA-IR)、血脂等實驗室指標,統計代謝綜閤徵髮生情況.結果 兩組患者初潮年齡、髮病年齡、孕次、產次比較差異均無統計學意義(P＞0.05).研究組收縮壓、舒張壓、體質指數、腹圍、空腹血糖、空腹胰島素、HOMA-IR、三酰甘油均明顯高于對照組[(129±13) mm Hg(1 mm Hg=0.133 kPa)比(112±14) mm Hg、(87±11) mm Hg比(75±8)mm Hg、(26.7±2.8)kg/m2比(22.2±2.1)kg/m2、(88±7) cm比(76±9)cm、(6.5±2.9) mmol/L比(4.7±0.9) mmol/L、(9.2±4.7)mU/L比(5.2±3.0) mU/L、3.9±0.8比3.1±0.6、(3.21±1.96) mmol/L比(1.56±1.22) mmol/L],高密度脂蛋白膽固醇明顯低于對照組[(1.25±0.51) mmol/L比(1.65±0.47) mmol/L],差異均有統計學意義(P＜0.05).研究組代謝綜閤徵髮生率為37.60％(135/359),其中卵巢癌患者髮生率為37.32％(53/142),子宮內膜癌患者為43.51％(57/131),子宮頸癌患者為29.07％(25/86),均明顯高于對照組的12.25％(49/400),差異有統計學意義(P＜0.05).結論 婦科噁性腫瘤患者代謝綜閤徵髮生率明顯高于婦科良性腫瘤患者,婦科噁性腫瘤與代謝綜閤徵間存在相互促進和影響的關繫.重視代謝綜閤徵在婦科噁性腫瘤髮生和髮展中可能產生的影響,併積極控製代謝綜閤徵,對婦科噁性腫瘤的預防和治療具有重要意義.
목적 탐토부과악성종류여대사종합정간적관계,지도부과악성종류적예방화치료.방법 선택부과악성종류환자359례(연구조,기중란소암142례,자궁내막암131례,자궁경암86례)화부과량성종류환자400례(대조조),비교량조환자일반정황、체격검사정황급공복혈당、공복이도소、은태모형평고법이도소저항지수(HOMA-IR)、혈지등실험실지표,통계대사종합정발생정황.결과 량조환자초조년령、발병년령、잉차、산차비교차이균무통계학의의(P＞0.05).연구조수축압、서장압、체질지수、복위、공복혈당、공복이도소、HOMA-IR、삼선감유균명현고우대조조[(129±13) mm Hg(1 mm Hg=0.133 kPa)비(112±14) mm Hg、(87±11) mm Hg비(75±8)mm Hg、(26.7±2.8)kg/m2비(22.2±2.1)kg/m2、(88±7) cm비(76±9)cm、(6.5±2.9) mmol/L비(4.7±0.9) mmol/L、(9.2±4.7)mU/L비(5.2±3.0) mU/L、3.9±0.8비3.1±0.6、(3.21±1.96) mmol/L비(1.56±1.22) mmol/L],고밀도지단백담고순명현저우대조조[(1.25±0.51) mmol/L비(1.65±0.47) mmol/L],차이균유통계학의의(P＜0.05).연구조대사종합정발생솔위37.60％(135/359),기중란소암환자발생솔위37.32％(53/142),자궁내막암환자위43.51％(57/131),자궁경암환자위29.07％(25/86),균명현고우대조조적12.25％(49/400),차이유통계학의의(P＜0.05).결론 부과악성종류환자대사종합정발생솔명현고우부과량성종류환자,부과악성종류여대사종합정간존재상호촉진화영향적관계.중시대사종합정재부과악성종류발생화발전중가능산생적영향,병적겁공제대사종합정,대부과악성종류적예방화치료구유중요의의.
Objective To investigate the relationship between gynecologic malignant neoplasms and metabolic syndrome (MS),in order to give a direction to the prevention and treatment of gynecologic malignant neoplasms.Methods A total of 359 cases of gynecologic malignant neoplasms (including 142cases of ovarian cancer,131 cases of endometrial cancer,86 cases of cervix cancer) were enrolled as study group,and 400 cases of gynecologic benign neoplasms were enrolled as control group.The general conditions,physical examination,fasting blood glucose,fasting insulin,homeostatic model assessment insulin resistance index (HOMA-IR),blood fat were compared between two groups.Clinical characteristics between two groups were compared.The occurrence of MS was counted.Results There was no significant difference in menarche age,onset age,gravidity and parity between two groups (P ＞0.05).The level of systolic pressure,diastolic pressure,body mass index,abdominal circumference,fasting blood glucose,fasting insulin,HOMA-IR,triacylglycerol in study group was higher than that in control group [(129 ± 13)mmHg (1mmHg=0.133kPa)vs.(112±14)mmHg,(87±11)mmHgvs.(75±8) mmHg,(26.7±2.8) kg/m2 vs.(22.2 ±2.1) kg/m2,(88 ±7) cm vs.(76 ±9) cm,(6.5 ±2.9) mmol/L vs.(4.7 ±0.9)mmol/L,(9.2 ± 4.7) mU/L vs.(5.2 ± 3.0) mU/L,3.9 ± 0.8 vs.3.1 ± 0.6,(3.21 ± 1.96) mmol/L vs.(1.56 ±1.22) mmol/L],and the level of high density lipoprotein cholesferol was lower than that in control group [(1.25 ± 0.51) mmol/L vs.(1.65 ± 0.47) mmol/L],and there were significant difference between two groups (P ＜ 0.05).The occurrence of MS in study group was 37.60％ (135/359),among of them,37.32％ (53/142)in ovarian cancer,43.51％(57/131) in endometrial cancer,29.07％ (25/86) in cervix cancer,which was higher than that in control group [12.25％ (49/400)],and there was significant difference (P ＜0.05).Conclusions The occurrence of MS in gynecologic malignant neoplasms is higher than that in gynecologic benign neoplasms,and there is a mutual promotion and influence of the relationship between gynecologic malignant neoplasms and MS.It suggests that there is a possible role of MS in the occurrence and development of gynecologic neoplasms,gynecologist should pay attention to it and control MS actively,those measures could make important significance of prevention and treatment for gynecologic malignant neoplasms.
