CAJ | 학술논문

目的分析子宫内膜癌手术患者代谢综合征病理状态及子宫内膜癌组织微RNA-205表达情况.方法收集38例子宫内膜癌患者腰围、体重、血压等一般资料,采集术前空腹血、术后内膜病灶及癌旁内膜组织石蜡切片.对患者代谢综合征病理状态指标进行分析,提取内膜组织总RNA,检测微RNA-205含量.结果子宫内膜癌患者代谢综合征患病率44.74％(17/38),高密度脂蛋白胆固醇、血压、三酰甘油、腰围、空腹血糖的异常率分别为52.6％ (20/38)、36.8％(14/38)、34.2％(13/38)、34.2％(13/38)和26.3％(10/38).子宫内膜癌组织中微RNA-205的表达量明显高于正常内膜组织,差异有统计学意义(P＜0.01).结论子宫内膜癌与代谢综合征及其组分关系密切；微RNA-205参与了子宫内膜癌的发生、发展过程,有可能作为早期筛查的分子标记物.
목적 분석자궁내막암수술환자대사종합정병리상태급자궁내막암조직미RNA-205표체정황.방법 수집38례자궁내막암환자요위、체중、혈압등일반자료,채집술전공복혈、술후내막병조급암방내막조직석사절편.대환자대사종합정병리상태지표진행분석,제취내막조직총RNA,검측미RNA-205함량.결과 자궁내막암환자대사종합정환병솔44.74％(17/38),고밀도지단백담고순、혈압、삼선감유、요위、공복혈당적이상솔분별위52.6％ (20/38)、36.8％(14/38)、34.2％(13/38)、34.2％(13/38)화26.3％(10/38).자궁내막암조직중미RNA-205적표체량명현고우정상내막조직,차이유통계학의의(P＜0.01).결론 자궁내막암여대사종합정급기조분관계밀절；미RNA-205삼여료자궁내막암적발생、발전과정,유가능작위조기사사적분자표기물.
Objective To detect the pathological state of metabolic syndrome and the expression of microRNA-205 in women with endometrial cancer.Methods Thirty-eight cases of patients with endometrial cancer were collected including waist circumference,weight,blood pressure.Collected preoperative fasting blood,postoperative endometrial lesions and endometrium tissue adjacent to carcinoma paraffin section.Analyzed the metabolic syndrome in patients with pathological state indicators,extracted the total RNA of endometrium tissue and the level of microRNA-205 was detected.Results The prevalence of metabolic syndrome was 44.74％ (17/38).The abnormal rate of high-density lipoprotein cholesterol,blood pressure,triglycerides,waist circumference,fasting blood sugar successively were 52.6％ (20/38),36.8％ (14/38),34.2％ (13/38),34.2％ (13/38) and 26.3％ (10/38).The expression level of microRNA-205 in endometrial carcinoma was higher than that in normal endometrium tissues,there was significant difference (P ＜ 0.01).Conclusions Metabolic syndrome is closely associated with the metabolic syndrome and its components.The expressions of microRNA-205 may participate in the occurrence and development of endometrial carcinoma,and it may be as an early screening of molecular markers.