CAJ | 학술논문

目的探讨功能性消化不良(FD)患者胃电图与胃排空的相关性及影响因素.方法使用PolygrafID四导胃电分析系统和不透X线标记物法测定51例FD患者的胃电活动和餐后5h的胃排空情况.结果 FD患者胃排空异常占31.4％(16/51),胃电图异常占72.5％(37/51).胃电图正常患者与胃电图异常患者胃排空率比较差异无统计学意义(P＞0.05).当胃排空和胃电图异常时,患者胃电节律紊乱,主频正常,部分患者合并餐后主功率不增加.轻、中及重度症状患者胃排空率比较差异无统计学意义(P＞0.05)；重度症状患者胃电图异常率较轻、中度症患者组明显增高[92.9％(13/14)比62.5％(10/16)、66.7％(14/21)],差异有统计学意义(P＜0.05),轻度与中度症状患者胃电图异常率比较差异无统计学意义(P＞0.05).幽门螺杆菌(Hp)阳性患者与Hp阴性患者的胃排空率比较差异无统计学意义(P＞0.05),Hp阳性患者胃电图异常率高于Hp阴性患者[90.0％(18/20)比61.3％(19/31)],差异有统计学意义(P＜0.05).有、无活动性胃炎患者的胃电图异常率及胃排空率比较差异均无统计学意义(P＞0.05).结论胃电图异常在FD的发病中有一定意义；胃排空延缓与胃电图异常无明显联系；重度症状患者和Hp阳性患者胃电图异常率明显增高；有或无活动性胃炎与胃电活动及胃排空无明显相关性.
목적 탐토공능성소화불량(FD)환자위전도여위배공적상관성급영향인소.방법 사용PolygrafID사도위전분석계통화불투X선표기물법측정51례FD환자적위전활동화찬후5h적위배공정황.결과 FD환자위배공이상점31.4％(16/51),위전도이상점72.5％(37/51).위전도정상환자여위전도이상환자위배공솔비교차이무통계학의의(P＞0.05).당위배공화위전도이상시,환자위전절률문란,주빈정상,부분환자합병찬후주공솔불증가.경、중급중도증상환자위배공솔비교차이무통계학의의(P＞0.05)；중도증상환자위전도이상솔교경、중도증환자조명현증고[92.9％(13/14)비62.5％(10/16)、66.7％(14/21)],차이유통계학의의(P＜0.05),경도여중도증상환자위전도이상솔비교차이무통계학의의(P＞0.05).유문라간균(Hp)양성환자여Hp음성환자적위배공솔비교차이무통계학의의(P＞0.05),Hp양성환자위전도이상솔고우Hp음성환자[90.0％(18/20)비61.3％(19/31)],차이유통계학의의(P＜0.05).유、무활동성위염환자적위전도이상솔급위배공솔비교차이균무통계학의의(P＞0.05).결론 위전도이상재FD적발병중유일정의의；위배공연완여위전도이상무명현련계；중도증상환자화Hp양성환자위전도이상솔명현증고；유혹무활동성위염여위전활동급위배공무명현상관성.
Objective To investigate the correlation between electrogastrogram and gastric emptying in functional dyspepsia (FD) patients.Methods Fifty-one patients with FD were detected by polygraf ID 4-channel electrogastrogram(EGG) analysis system and solid radiopaque marker 5 h after a solid meal.Results 31.4％ (16/51) patients showed delayed gastric emptying(GE),and 72.5％(37/51) patients showed abnormal EGG.The rate of GE between normal EGG patients and abnormal EGG patients had no significant difference(P ＞ 0.05).In patients who had both abnormal EGG and delayed GE,EGG abnormality mainly exhibited dysrhythmia and the dominant frequency of EGG was normal.Some patients also exhibited non enhanced postprandial dominant power.The rate of GE among mild,moderate and severe symptom patients had no significant difference (P ＞ 0.05).The rate of abnormal EGG in severe symptom patients was significantly higher than that in mild and moderate symptom patients [92.9％ (13/14) vs.62.5％ (10/16),66.7％(14/21)] (P ＜0.05).The rate of abnormal EGG in mild and moderate symptom patients had no significant difference (P ＞ 0.05).The rate of GE between Helicobacter pylori (Hp) positive patients and Hp negative patients had no significant difference (P ＞ 0.05).The rate of abnormal EGG in Hp positive patients was significantly higher than that in Hp negative patients [90.0％ (18/20) vs.61.3％ (19/31)] (P ＜ 0.05).The rate of GE and the rate of abnormal EGG had no significant difference between patients with and without active gastritis(P ＞ 0.05).Conclusions The abnormality of EGG plays an important role in the pathogenesis of FD.There is no significant relationship between EGG and GE.The patients with severe symptom and with Hp positive have higher abnormal EGG percentage.Gastritis has no significant correlation with EGG or GE.