中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
30期
16-18
,共3页
李冰%沈芊%黄辉红%郭娟荪%汪道伟
李冰%瀋芊%黃輝紅%郭娟蓀%汪道偉
리빙%침천%황휘홍%곽연손%왕도위
脂肪酸结合蛋白质类%非酒精性脂肪肝
脂肪痠結閤蛋白質類%非酒精性脂肪肝
지방산결합단백질류%비주정성지방간
Fatty acid-binding proteins%Nonalcoholic fatty liver disease
目的 探讨血清肝型脂肪酸结合蛋白(L-FABP)与非酒精性脂肪性肝病(NAFLD)患者疾病严重程度及脂代谢相关临床生化指标的相互关系.方法 选择96例NAFLD患者(观察组)及100例健康体检者(对照组),用酶联免疫吸附法测定血清L-FABP及血生化指标,超声判定病变程度,同时计算体质指数(BMI)、腰臀比(WHR)及稳态模型评估法胰岛素抵抗指数(HOMA-IR).结果 观察组WHR、BMI、空腹血糖(FBG)、三酰甘油(TG)、丙氨酸氨基转移酶(ALT)、HOMA-IR及L-FABP水平明显高于对照组,差异均有统计学意义(P＜0.05).相关性分析结果表明,L-FABP水平与ALT(r=0.735)、TG(r=0.728)、FBG(r=0.681)、WHR(r=0.713)、BMI(r=0.699)、HOMA-IR(r=0.673)均呈正相关(P＜0.05),与HDL-C呈负相关(r=-0.607,P＜ 0.05).对照组L-FABP水平为(15.42±2.51) g/L,轻度NAFLD为(15.96±2.92) g/L,中度NAFLD为(17.48±3.91) g/L,重度NAFLD为(25.14±5.37) g/L.重度NAFLD患者L-FABP水平与对照组及轻、中度NAFLD患者比较差异均有统计学意义(P＜0.05).结论 重度NAFLD患者血清L-FABP水平明显增高,L-FABP水平与一些肝功能生化指标有关.
目的 探討血清肝型脂肪痠結閤蛋白(L-FABP)與非酒精性脂肪性肝病(NAFLD)患者疾病嚴重程度及脂代謝相關臨床生化指標的相互關繫.方法 選擇96例NAFLD患者(觀察組)及100例健康體檢者(對照組),用酶聯免疫吸附法測定血清L-FABP及血生化指標,超聲判定病變程度,同時計算體質指數(BMI)、腰臀比(WHR)及穩態模型評估法胰島素牴抗指數(HOMA-IR).結果 觀察組WHR、BMI、空腹血糖(FBG)、三酰甘油(TG)、丙氨痠氨基轉移酶(ALT)、HOMA-IR及L-FABP水平明顯高于對照組,差異均有統計學意義(P＜0.05).相關性分析結果錶明,L-FABP水平與ALT(r=0.735)、TG(r=0.728)、FBG(r=0.681)、WHR(r=0.713)、BMI(r=0.699)、HOMA-IR(r=0.673)均呈正相關(P＜0.05),與HDL-C呈負相關(r=-0.607,P＜ 0.05).對照組L-FABP水平為(15.42±2.51) g/L,輕度NAFLD為(15.96±2.92) g/L,中度NAFLD為(17.48±3.91) g/L,重度NAFLD為(25.14±5.37) g/L.重度NAFLD患者L-FABP水平與對照組及輕、中度NAFLD患者比較差異均有統計學意義(P＜0.05).結論 重度NAFLD患者血清L-FABP水平明顯增高,L-FABP水平與一些肝功能生化指標有關.
목적 탐토혈청간형지방산결합단백(L-FABP)여비주정성지방성간병(NAFLD)환자질병엄중정도급지대사상관림상생화지표적상호관계.방법 선택96례NAFLD환자(관찰조)급100례건강체검자(대조조),용매련면역흡부법측정혈청L-FABP급혈생화지표,초성판정병변정도,동시계산체질지수(BMI)、요둔비(WHR)급은태모형평고법이도소저항지수(HOMA-IR).결과 관찰조WHR、BMI、공복혈당(FBG)、삼선감유(TG)、병안산안기전이매(ALT)、HOMA-IR급L-FABP수평명현고우대조조,차이균유통계학의의(P＜0.05).상관성분석결과표명,L-FABP수평여ALT(r=0.735)、TG(r=0.728)、FBG(r=0.681)、WHR(r=0.713)、BMI(r=0.699)、HOMA-IR(r=0.673)균정정상관(P＜0.05),여HDL-C정부상관(r=-0.607,P＜ 0.05).대조조L-FABP수평위(15.42±2.51) g/L,경도NAFLD위(15.96±2.92) g/L,중도NAFLD위(17.48±3.91) g/L,중도NAFLD위(25.14±5.37) g/L.중도NAFLD환자L-FABP수평여대조조급경、중도NAFLD환자비교차이균유통계학의의(P＜0.05).결론 중도NAFLD환자혈청L-FABP수평명현증고,L-FABP수평여일사간공능생화지표유관.
Objective To investigate the correlation between liver-type fatty acid binding protein (L-FABP) and nonalcoholic fatty liver disease (NAFLD) extent and other clinical parameters.Methods Ninety-six patients of NAFLD (NAFLD group) and 100 cases of healthy controls (control group) were selected.The levels of serum L-FABP and blood biochemical parameters were measured by enzyme-linked immunosorbent assay.The lesion degree was assessed by ultrasound.The body mass index (BMI),waist to hip ratio (WHR) and homeostasis model assessment insulin resistance index (HOMA-IR) were calculated.Results The WHR,BMI,fasting plasma glucose (FBG),triglycerides (TG),alanine aminotransferase (ALT),HOMA-IR and L-FABP in NAFLD group were higher than those in control group,there were statistical differences (P ＜ 0.05).The result of correlation analysis showed L-FABP level was positively related with ALT,TG,FBG,WHR,BMI,HOMA-IR (r =0.735,0.728,0.681,0.713,0.699,0.673 ;P ＜0.05),and negative correlation with HDL-C (r =-0.607,P ＜ 0.05).The L-FABP level in control group was (15.42 ± 2.51) g/L,mild NAFLD was (15.96 ± 2.92) g/L,moderate NAFLD was (17.48 ± 3.91) g/L,serious NAFLD was (25.14 ± 5.37) g/L.There was statistical difference in L-FABP level between serious NAFLD and control group,mild NAFLD,moderate NAFLD (P ＜ 0.05).Conclusion Serum L-FABP level of serious NAFLD patient significantly increases,and L-FABP level is related with biochemical parameters of liver function.
