CAJ | 학술논문

目的探讨脂蛋白(a)[Lp(a)]、同型半胱氨酸(Hcy)与男性冠状动脉疾病(CAD)发生的关系.方法选取222例男性患者为研究对象,按照冠状动脉造影结果,将其分为CAD阳性组(111例)与CAD阴性组(111例).比较两组一般临床资料以及血浆Lp(a)和Hcy水平.采用Logistic回归分析影响男性CAD发生的危险因素.结果 Lp(a)水平≥0.3 g/L时,可以引起CAD的发生(OR=5.04,95％CI1.88～13.51,P=0.001).而Hcy与CAD的发生无相关性(OR=1.35,95％ CI0.63～2.89,P=0.443).但当考虑两个因素交互作用时,血浆中较高的Lp(a)和Hcy水平是CAD发生的危险因素(OR=11.54,95％ CI 2.62～45.61,P=0.003).结论血浆Lp(a)和Hcy水平升高可能加快男性CAD的发病进程.
목적 탐토지단백(a)[Lp(a)]、동형반광안산(Hcy)여남성관상동맥질병(CAD)발생적관계.방법 선취222례남성환자위연구대상,안조관상동맥조영결과,장기분위CAD양성조(111례)여CAD음성조(111례).비교량조일반림상자료이급혈장Lp(a)화Hcy수평.채용Logistic회귀분석영향남성CAD발생적위험인소.결과 Lp(a)수평≥0.3 g/L시,가이인기CAD적발생(OR=5.04,95％CI1.88～13.51,P=0.001).이Hcy여CAD적발생무상관성(OR=1.35,95％ CI0.63～2.89,P=0.443).단당고필량개인소교호작용시,혈장중교고적Lp(a)화Hcy수평시CAD발생적위험인소(OR=11.54,95％ CI 2.62～45.61,P=0.003).결론 혈장Lp(a)화Hcy수평승고가능가쾌남성CAD적발병진정.
Objective To discuss the rehtionship between lipoprotein [Lp (a)],homocysteine (Hcy) and coronary artery disease (CAD) in men.Methods Two hundred and twenty-two male patients admitted for coronary angiography were classified into CAD positive group (111 cases) and CAD negative group (111 cases).The clinical data and plasma Hcy and Lp(a) levels were recorded in both groups.Logistic regression analysis was used to analyze males CAD risk factors.Results Lp (a) ≥0.3 g/L was a risk factor for CAD (OR =5.04,95％ CI 1.88-13.51,P =0.001),whereas Hcy was not related to CAD (OR =1.35,95％ CI 0.63-2.89,P =0.443).However,when both factors were considered together in an interaction model,plasma high Hcy and high Lp (a) levels were risk factors for CAD (OR =11.54,95％ CI 2.62-45.61,P=0.003).Conclusion Plasma Lp (a) and Hcy levels may increase the incidence of male CAD process.