中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
33期
17-20
,共4页
鼻炎%白细胞介素%微量元素%黏附分子
鼻炎%白細胞介素%微量元素%黏附分子
비염%백세포개소%미량원소%점부분자
Rhinitis%Interleukin%Trace elements%Adhesion molecule
目的 研究过敏性鼻炎患者血清白细胞介素(IL)、微量元素及黏附分子的变化规律.方法 选取2011年3月至2013年3月诊治的47例过敏性鼻炎患者作为观察组,其中间歇性27例,持续性20例;轻度15例,中度19例,重度13例.选取同期47例健康体检者作为对照组.对两组血清IL、微量元素及黏附分子水平进行比较,并将观察组中不同分型及严重程度者的上述指标进行比较.结果 观察组血清IL-4、IL-5、IL-6、IL-1O、可溶性细胞间黏附分子1、可溶性血管细胞黏附因子1、可溶性P选择素、可溶性E选择素水平均高于对照组[(28.97±3.27) ng/L比(4.35±0.65) ng/L、(17.46±2.15) ng/L比(2.71±0.34) ng/L、(10.39±1.28) ng/L比(5.96±0.94) ng/L、(31.36±3.44) ng/L比(5.53±0.76) ng/L、(483.72±39.25) μg/L比(319.65±29.86)μg/L、(516.85±50.27)μg/L比(327.46±31.53) μg/L、(12.58±1.36) μg/L比(3.43±0.76) μg/L、(31.34±2.84) μ g/L比(10.22±1.52) μ g/L],差异均有统计学意义(P值均＜0.05).观察组血清锌低于对照组[(7.14±1.35) μmol/L比(16.83±1.71)μtmol/L],血清铜、锰高于对照组[(23.24±2.79) μmol/L比(13.15±2.08)μmol/L、(4.13±0.27)μmol/L比(2.24±0.19)μmol/L],差异均有统计学意义(P值均＜0.05).观察组中持续性过敏性鼻炎及重度患者上述指标的变化大于间歇性过敏性鼻炎及轻度、中度患者,差异均有统计学意义(P值均＜ 0.05).结论 过敏性鼻炎患者血清IL、微量元素及黏附分子的变化较大,且不同分型及严重程度者之间的差异也较为突出,可作为临床诊治的重要依据.
目的 研究過敏性鼻炎患者血清白細胞介素(IL)、微量元素及黏附分子的變化規律.方法 選取2011年3月至2013年3月診治的47例過敏性鼻炎患者作為觀察組,其中間歇性27例,持續性20例;輕度15例,中度19例,重度13例.選取同期47例健康體檢者作為對照組.對兩組血清IL、微量元素及黏附分子水平進行比較,併將觀察組中不同分型及嚴重程度者的上述指標進行比較.結果 觀察組血清IL-4、IL-5、IL-6、IL-1O、可溶性細胞間黏附分子1、可溶性血管細胞黏附因子1、可溶性P選擇素、可溶性E選擇素水平均高于對照組[(28.97±3.27) ng/L比(4.35±0.65) ng/L、(17.46±2.15) ng/L比(2.71±0.34) ng/L、(10.39±1.28) ng/L比(5.96±0.94) ng/L、(31.36±3.44) ng/L比(5.53±0.76) ng/L、(483.72±39.25) μg/L比(319.65±29.86)μg/L、(516.85±50.27)μg/L比(327.46±31.53) μg/L、(12.58±1.36) μg/L比(3.43±0.76) μg/L、(31.34±2.84) μ g/L比(10.22±1.52) μ g/L],差異均有統計學意義(P值均＜0.05).觀察組血清鋅低于對照組[(7.14±1.35) μmol/L比(16.83±1.71)μtmol/L],血清銅、錳高于對照組[(23.24±2.79) μmol/L比(13.15±2.08)μmol/L、(4.13±0.27)μmol/L比(2.24±0.19)μmol/L],差異均有統計學意義(P值均＜0.05).觀察組中持續性過敏性鼻炎及重度患者上述指標的變化大于間歇性過敏性鼻炎及輕度、中度患者,差異均有統計學意義(P值均＜ 0.05).結論 過敏性鼻炎患者血清IL、微量元素及黏附分子的變化較大,且不同分型及嚴重程度者之間的差異也較為突齣,可作為臨床診治的重要依據.
목적 연구과민성비염환자혈청백세포개소(IL)、미량원소급점부분자적변화규률.방법 선취2011년3월지2013년3월진치적47례과민성비염환자작위관찰조,기중간헐성27례,지속성20례;경도15례,중도19례,중도13례.선취동기47례건강체검자작위대조조.대량조혈청IL、미량원소급점부분자수평진행비교,병장관찰조중불동분형급엄중정도자적상술지표진행비교.결과 관찰조혈청IL-4、IL-5、IL-6、IL-1O、가용성세포간점부분자1、가용성혈관세포점부인자1、가용성P선택소、가용성E선택소수평균고우대조조[(28.97±3.27) ng/L비(4.35±0.65) ng/L、(17.46±2.15) ng/L비(2.71±0.34) ng/L、(10.39±1.28) ng/L비(5.96±0.94) ng/L、(31.36±3.44) ng/L비(5.53±0.76) ng/L、(483.72±39.25) μg/L비(319.65±29.86)μg/L、(516.85±50.27)μg/L비(327.46±31.53) μg/L、(12.58±1.36) μg/L비(3.43±0.76) μg/L、(31.34±2.84) μ g/L비(10.22±1.52) μ g/L],차이균유통계학의의(P치균＜0.05).관찰조혈청자저우대조조[(7.14±1.35) μmol/L비(16.83±1.71)μtmol/L],혈청동、맹고우대조조[(23.24±2.79) μmol/L비(13.15±2.08)μmol/L、(4.13±0.27)μmol/L비(2.24±0.19)μmol/L],차이균유통계학의의(P치균＜0.05).관찰조중지속성과민성비염급중도환자상술지표적변화대우간헐성과민성비염급경도、중도환자,차이균유통계학의의(P치균＜ 0.05).결론 과민성비염환자혈청IL、미량원소급점부분자적변화교대,차불동분형급엄중정도자지간적차이야교위돌출,가작위림상진치적중요의거.
Objective To observe and study the variation ofinterleukin (IL),trace elements and adhesion molecule in allergic rhinitis patients.Methods Forty-seven allergic rhinitis patients who were diagnosed from March 2011 to March 2013 were selected as observation group.Among the total,intermittence was 27 patients,continuity was 20 patients,mild was 15 patients,moderate was 19 patients,severe was 13 patients.Forty-seven healthy person at the same time were selected as control group.The level of IL,trace elements and adhesion molecule in two groups were compared,and all the indexes of observation group with different types and severity were compared too.Results The level of IL-4,IL-5,IL-6,IL-10,soluble intercellular adhesion molecule (sICAM)-1,soluble vascular cell adhesion molecule (sVCAM)-1,soluble P-selectin (sP-selectin),soluble E-selectin (sE-selectin) in observation group were significantly higher than those in control group [(28.97 ± 3.27) ng/L vs.(4.35 ± 0.65) ng/L,(17.46 ± 2.15) ng/L vs.(2.71 ± 0.34)ng/L,(10.39 ± 1.28) ng/L vs.(5.96 ± 0.94) ng/L,(31.36 ± 3.44) ng/L vs.(5.53 ± 0.76) ng/L,(483.72 ± 39.25) μ g/L vs.(319.65 ± 29.86) μ g/L,(516.85 ± 50.27) μ g/L vs.(327.46 ± 31.53)μg/L,(12.58 ± 1.36) μg/Lvs.(3.43±0.76) μg/L,(31.34 ±2.84) μg/L vs.(10.22± 1.52)lμg/L] (P＜0.05).The level of serum Zn in observation group was significantly lower than that in control group[(7.14 ±1.35) μ mol/L vs.(16.83 ± 1.71) μ mol/L] (P ＜ 0.05).The level of serum Cu and Mn in observation group were significantly higher than those in control group [(23.24 ± 2.79) μ mol/L vs.(13.15 ± 2.08) μ mol/L,(4.13 ± 0.27) μ mol/L vs.(2.24 ± 0.19) μ mol/L] (P ＜ 0.05).In observation group,the change of above indexes in continuity and severe patients had significant difference compared with intermittence and mild,moderate patients (P ＜ 0.05).Conclusions The change of IL,trace elements and adhesion molecule in allergic rhinitis patients are obviously,and among different types and degrees,the change are obviously too.So,these indexes can be the important basis of clinical diagnosis and treatment.
