中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
35期
33-34,38
,共3页
脊柱炎,强直性%白细胞介素22
脊柱炎,彊直性%白細胞介素22
척주염,강직성%백세포개소22
Spondylitis,ankylosing%Interleukin-22
目的 探讨强直性脊柱炎患者外周血白细胞介素(IL)-22的表达水平及临床意义.方法 选择30例强直性脊柱炎患者和30例健康体检者,采用实时定量PCR检测外周血IL-22mRNA表达水平,酶联免疫吸附法检测血浆IL-22水平.结果 强直性脊柱炎患者外周血IL-22mRNA表达水平和血浆IL-22水平均明显高于健康体检者[1.82±0.79比1.31±0.63和(47.08±17.25) ng/L比(30.47±11.24) ng/L],差异有统计学意义(P＜0.05).结论 强直性脊柱炎患者外周血IL-22水平增高,IL-22可能参与了强直性脊柱炎的发病.
目的 探討彊直性脊柱炎患者外週血白細胞介素(IL)-22的錶達水平及臨床意義.方法 選擇30例彊直性脊柱炎患者和30例健康體檢者,採用實時定量PCR檢測外週血IL-22mRNA錶達水平,酶聯免疫吸附法檢測血漿IL-22水平.結果 彊直性脊柱炎患者外週血IL-22mRNA錶達水平和血漿IL-22水平均明顯高于健康體檢者[1.82±0.79比1.31±0.63和(47.08±17.25) ng/L比(30.47±11.24) ng/L],差異有統計學意義(P＜0.05).結論 彊直性脊柱炎患者外週血IL-22水平增高,IL-22可能參與瞭彊直性脊柱炎的髮病.
목적 탐토강직성척주염환자외주혈백세포개소(IL)-22적표체수평급림상의의.방법 선택30례강직성척주염환자화30례건강체검자,채용실시정량PCR검측외주혈IL-22mRNA표체수평,매련면역흡부법검측혈장IL-22수평.결과 강직성척주염환자외주혈IL-22mRNA표체수평화혈장IL-22수평균명현고우건강체검자[1.82±0.79비1.31±0.63화(47.08±17.25) ng/L비(30.47±11.24) ng/L],차이유통계학의의(P＜0.05).결론 강직성척주염환자외주혈IL-22수평증고,IL-22가능삼여료강직성척주염적발병.
Objective To study the expression level of interleukin (IL)-22 in the peripheral blood of patients with ankylosing spondylitis and its clinical significance.Methods The mRNA level of IL-22 in the peripheral blood was measured by real-time quantitative polymerase chain reaction,and the plasma level of IL-22 was measured by enzyme linked immunosorbent assay in 30 patients with ankylosing spondylitis and 30 normal controls.Results The mRNA level of IL-22 in the peripheral blood and the plasma level of IL-22 in patients with ankylosing spondylitis were statistically higher than those in normal controls [1.82 ± 0.79 vs.1.31 ± 0.63 and (47.08 ± 17.25) ng/L vs.(30.47 ± 11.24) ng/L,P ＜ 0.05].Conclusion The level of IL-22 in the peripheral blood of patients with ankylosing spondylitis increases,and IL-22 may participate in the occurrence of ankylosing spondylitis.
