中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
4期
32-35
,共4页
利钠肽,脑%心力衰竭%舒张功能
利鈉肽,腦%心力衰竭%舒張功能
리납태,뇌%심력쇠갈%서장공능
Natriuretic peptide,brain%Heart failure%Diastolic function
目的 评价左房功能指数(LAFI)在左室射血分数正常心力衰竭(HFNEF)诊断中的价值.方法 选取HFNEF患者110例,按纽约心脏病协会(NYHA)心功能分级分为NYHAⅡ级组(43例)、NYHAⅢ级组(40例)和NYHAⅣ级组(27例),另选择健康体检者33例作为对照组.均行超声心动图检查,并计算LAFI和舒张早期二尖瓣血流速度/舒张早期二尖瓣环运动速度(E/E’),同期行血浆脑钠肽(BNP)测定,观察LAFI与NYHA心功能分级之间的关系,及LAFI与血浆BNP、E/E,的相关性.结果 心功能越差,血浆BNP、E/E’越高,LAFI越低,差异均有统计学意义[对照组:(40.9±26.1) ng/L,6.4±2.0,0.73±0.10,NYHAⅡ级组:(230.1±85.9) ng/L,10.0±3.7,0.46±0.30,NYHAⅢ级组:(398.6±98.7) ng/L、16.9±4.0,0.26±0.30,NYHAⅣ级组:(680.3±146.6) ng/L,23.8±3.9,0.17±0.20,P＜0.05].相关性分析结果显示HFNEF患者LAFI与血浆BNP、E/E’均呈负相关(r＝-0.868,-0.873,P＜0.01).结论 HFNEF患者LAFI与左室舒张功能障碍有很好的相关性,LAFI能够很好地早期诊断和评价左室舒张功能.
目的 評價左房功能指數(LAFI)在左室射血分數正常心力衰竭(HFNEF)診斷中的價值.方法 選取HFNEF患者110例,按紐約心髒病協會(NYHA)心功能分級分為NYHAⅡ級組(43例)、NYHAⅢ級組(40例)和NYHAⅣ級組(27例),另選擇健康體檢者33例作為對照組.均行超聲心動圖檢查,併計算LAFI和舒張早期二尖瓣血流速度/舒張早期二尖瓣環運動速度(E/E’),同期行血漿腦鈉肽(BNP)測定,觀察LAFI與NYHA心功能分級之間的關繫,及LAFI與血漿BNP、E/E,的相關性.結果 心功能越差,血漿BNP、E/E’越高,LAFI越低,差異均有統計學意義[對照組:(40.9±26.1) ng/L,6.4±2.0,0.73±0.10,NYHAⅡ級組:(230.1±85.9) ng/L,10.0±3.7,0.46±0.30,NYHAⅢ級組:(398.6±98.7) ng/L、16.9±4.0,0.26±0.30,NYHAⅣ級組:(680.3±146.6) ng/L,23.8±3.9,0.17±0.20,P＜0.05].相關性分析結果顯示HFNEF患者LAFI與血漿BNP、E/E’均呈負相關(r＝-0.868,-0.873,P＜0.01).結論 HFNEF患者LAFI與左室舒張功能障礙有很好的相關性,LAFI能夠很好地早期診斷和評價左室舒張功能.
목적 평개좌방공능지수(LAFI)재좌실사혈분수정상심력쇠갈(HFNEF)진단중적개치.방법 선취HFNEF환자110례,안뉴약심장병협회(NYHA)심공능분급분위NYHAⅡ급조(43례)、NYHAⅢ급조(40례)화NYHAⅣ급조(27례),령선택건강체검자33례작위대조조.균행초성심동도검사,병계산LAFI화서장조기이첨판혈류속도/서장조기이첨판배운동속도(E/E’),동기행혈장뇌납태(BNP)측정,관찰LAFI여NYHA심공능분급지간적관계,급LAFI여혈장BNP、E/E,적상관성.결과 심공능월차,혈장BNP、E/E’월고,LAFI월저,차이균유통계학의의[대조조:(40.9±26.1) ng/L,6.4±2.0,0.73±0.10,NYHAⅡ급조:(230.1±85.9) ng/L,10.0±3.7,0.46±0.30,NYHAⅢ급조:(398.6±98.7) ng/L、16.9±4.0,0.26±0.30,NYHAⅣ급조:(680.3±146.6) ng/L,23.8±3.9,0.17±0.20,P＜0.05].상관성분석결과현시HFNEF환자LAFI여혈장BNP、E/E’균정부상관(r＝-0.868,-0.873,P＜0.01).결론 HFNEF환자LAFI여좌실서장공능장애유흔호적상관성,LAFI능구흔호지조기진단화평개좌실서장공능.
Objective To assess the clinical diagnostic value of left atrial function index (LAFI) for heart failure with normal left ventricular ejection fraction (HFNEF).Methods One hundred and ten patients with HFNEF were divided into 3 groups by New York Heart Association (NYHA) cardiac functional grading:NYHA Ⅱ grade group (43 cases),NYHA Ⅲ grade group (40 cases) and NYHA Ⅳ grade group (27 cases),and another 33 healthy subjects were selected as control group.The 4 groups were examined by ultrasoundcardiogram,LAFI and E/E' were calculated,and the plasma brain natriuretic peptide (BNP)levels were determined.The relation between LAFI and NYHA cardiac functional grading and the correlation between LAFI and plasma BNP,E/E' were observed.Results The worse heart function,the higher plasma BNP and E/E',and the lower LAFI,and there were statistical differences [control group:(40.9 ± 26.1) ng/L,6.4 ± 2.0,0.73 ± 0.10,NYHA Ⅱ grade group:(230.1 ± 85.9) ng/L,10.0 ± 3.7,0.46 ± 0.30,NYHA Ⅲ grade group:(398.6 ±98.7) ng/L,16.9 ±4.0,0.26 ± 0.30,NYHA Ⅳ grade group:(680.3 ± 146.6) ng/L,23.8 ± 3.9,0.17 ± 0.20,P ＜ 0.05].The correlation analysis results showed that LAFI and plasma BNP,E/E' were negatively correlated in patients with HFNEF (r =-0.868,-0.873,P ＜ 0.01).Conclusions In HFNEF patients,there is significant correlation between LAFI and left ventricular diastolic dysfunction.LAFI can well diagnose diastolic heart failure early and evaluate the diastolic function of the left ventricle.
