CAJ | 학술논문

目的比较生脉注射液联合化疗与单纯化疗治疗晚期食管癌的疗效及不良反应.方法将84例晚期食管癌患者随机分为两组:治疗组43例用生脉注射液50 ml/d静脉滴注20 d,配合DDP+CF/5-Fu方案化疗,对照组41例单纯用DDP+CF/5-Fu方案化疗,每3周重复1次,共2个化疗周期.治疗后评价两组患者的近期疗效、化疗毒副反应、中医症候及生活质量.结果近期疗效:治疗组有效率为58.1％,对照组为53.7％.治疗组毒副反应有所减轻,中医症候改善明显,生活质量提高(P＜0.01).结论生脉注射液可减轻晚期食管癌患者化疗所致毒副作用,改善中医症候,提高生活质量.
목적 비교생맥주사액연합화료여단순화료치료만기식관암적료효급불량반응.방법 장84례만기식관암환자수궤분위량조:치료조43례용생맥주사액50 ml/d정맥적주20 d,배합DDP+CF/5-Fu방안화료,대조조41례단순용DDP+CF/5-Fu방안화료,매3주중복1차,공2개화료주기.치료후평개량조환자적근기료효、화료독부반응、중의증후급생활질량.결과 근기료효:치료조유효솔위58.1％,대조조위53.7％.치료조독부반응유소감경,중의증후개선명현,생활질량제고(P＜0.01).결론 생맥주사액가감경만기식관암환자화료소치독부작용,개선중의증후,제고생활질량.
Objective To compare the curative effect and side effect of combined treatment with Shengmai injection and chemotherapy and only chemotherapy for patients with advanced esophageal cancer.Methods Patients with advanced esophageal cancer (n=84) were randomly divided into two groups.They were treated with Shengmai injection 50 ml/d for 20 days and DDP+CF/5-Fu chemotherapy (n=43),or with DDP+CF/5-Fu chemotherapy alone (control,n=41),all patients were treated not less than 2 cycles.Results The overall response rates of observation group and control group showed no significant difference; the life quality and relieved chemotherapy toxicity of patients in observation group were superior to those in control group.Conclusion Shengrnai injection can decrease toxic reaction and improve life quality of patients with advanced esophageal cancer.