CAJ | 학술논문

目的探讨原发性癫痫患者认知功能障碍的临床特征及其影响因素.方法使用中国修订韦氏成人智力量表(WAIS-RC)分别对70例原发性癫痫患者(癫痫组)和40例健康体检者(对照组)进行认知功能测定,并对影响测验得分的多种因素进行相关性分析.结果癫痫组患者的操作智商、言语智商、全量表智商得分均较对照组明显下降[(98.06±15.24)分比(113.80±12.14)分、(98.09 ± 16.06)分比(120.65±11.28)分、(98.06±15.80)分比(119.42±11.85)分],差异有统计学意义(P＜0.01).癫痫组11个分测验量表得分亦显著低于对照组,差异有统计学意义(P＜0.01).多元线性逐步回归分析结果显示癫痫患者的认知功能障碍与学历、年龄、病程、发作频率及发作持续时间、抗癫痫药物数量等密切相关.结论原发性癫痫患者的认知功能全面下降.临床上应重视原发性癫痫患者的认知功能状况,尽量减少或避免导致认知功能受损的危险因素发生,以提高癫痫患者的生活质量.
목적 탐토원발성전간환자인지공능장애적림상특정급기영향인소.방법 사용중국수정위씨성인지역량표(WAIS-RC)분별대70례원발성전간환자(전간조)화40례건강체검자(대조조)진행인지공능측정,병대영향측험득분적다충인소진행상관성분석.결과 전간조환자적조작지상、언어지상、전량표지상득분균교대조조명현하강[(98.06±15.24)분비(113.80±12.14)분、(98.09 ± 16.06)분비(120.65±11.28)분、(98.06±15.80)분비(119.42±11.85)분],차이유통계학의의(P＜0.01).전간조11개분측험량표득분역현저저우대조조,차이유통계학의의(P＜0.01).다원선성축보회귀분석결과현시전간환자적인지공능장애여학력、년령、병정、발작빈솔급발작지속시간、항전간약물수량등밀절상관.결론 원발성전간환자적인지공능전면하강.림상상응중시원발성전간환자적인지공능상황,진량감소혹피면도치인지공능수손적위험인소발생,이제고전간환자적생활질량.
Objective To observe the cognitive function and its related factors in patients with essential epilepsy.Methods The cognitive function of 70 essential epilepsy patients (epilepsy group) and 40 healthy controls(control group) were evaluated by means of Wechsler Intelligence Scale for Adult-Chinese (WAIS-RC).The relation between the cognitive dysfunction and its related factors were analyzed.Results The scores of performance intelligence quotient,verbal intelligence quotient,full intelligence quotient in epilepsy group were significantly lower than those in control group [(98.06 ± 15.24) scores vs.(113.80 ± 12.14) scores,(98.09 ± 16.06) scores vs.(120.65 ± 11.28) scores,(98.06 ± 15.80) scores vs.(119.42 ± 11.85) scores] (P ＜ 0.01).The scores of 11 numbers of rating scales were significantly lower than those in control group (P ＜ 0.01).The factors related to the cognitive function were education level,age numbers,duration of the disease,frequency of seizures attack before medication,the duration of seizures and the quantity of antiepileptics.Conclusions Many of the essential epilepsy patients have cognitive function deficit.The cognitive condition of essential epilepsy patients should be pay more attention and reduce the dangerous factors in order to improve the life quality.