CAJ | 학술논문

目的探讨ABO血型及胱抑素C与乙型肝炎肝硬化失代偿期的相关性,以便更好地指导临床诊治工作.方法回顾性分析472例乙型肝炎肝硬化失代偿期患者性别、年龄、乙型肝炎家族史、乙型肝炎病毒标记、肝功能分级、门静脉高压及并发症与ABO血型分布情况,比较胱抑素C与肌酐水平差异及其与肝功能分级关系,并与681例健康人群进行对比.结果乙型肝炎肝硬化失代偿期患者中,A型血发生率最高.各年龄组中ABO血型分布比较差异无统计学意义(P＞0.05).AB型血患者中有乙型肝炎家族史、门静脉宽度＞l.5cm、食管静脉曲张、有并发症及肝功能分级Child-Pugh C级所占比例均明显高于其他血型,差异有统计学意义(P＜0.01).胱抑素C水平随着肝功能分级升高而逐渐升高,差异有统计学意义(P＜0.05).结论 A型血的人群具有肝硬化的高危因素,AB型血的肝硬化患者其病情发展较其他血型者更严重.肝硬化失代偿期患者胱抑素C水平与尿素氮、肌酐相比明显高于健康者,胱抑素C水平随肝功能分级升高而呈升高趋势,同时胱抑素C具有成为肝功能分级的良好指标的潜力.
목적 탐토ABO혈형급광억소C여을형간염간경화실대상기적상관성,이편경호지지도림상진치공작.방법 회고성분석472례을형간염간경화실대상기환자성별、년령、을형간염가족사、을형간염병독표기、간공능분급、문정맥고압급병발증여ABO혈형분포정황,비교광억소C여기항수평차이급기여간공능분급관계,병여681례건강인군진행대비.결과 을형간염간경화실대상기환자중,A형혈발생솔최고.각년령조중ABO혈형분포비교차이무통계학의의(P＞0.05).AB형혈환자중유을형간염가족사、문정맥관도＞l.5cm、식관정맥곡장、유병발증급간공능분급Child-Pugh C급소점비례균명현고우기타혈형,차이유통계학의의(P＜0.01).광억소C수평수착간공능분급승고이축점승고,차이유통계학의의(P＜0.05).결론 A형혈적인군구유간경화적고위인소,AB형혈적간경화환자기병정발전교기타혈형자경엄중.간경화실대상기환자광억소C수평여뇨소담、기항상비명현고우건강자,광억소C수평수간공능분급승고이정승고추세,동시광억소C구유성위간공능분급적량호지표적잠력.
Objective To explore the correlation of ABO blood group and serum cystatin C level and decompensated hepatitis B cirrhosis.Methods Retrospectively analysed the clinical data of 472 patients with decompensated hepatitis B cirrhosis,and compared with 681 healthy control volunteers.All the informations such as gender,age,family history of liver disease,hepatitis B virus infection,hepatic function classification,complications of portal hypertension and the distribution of ABO blood group were observed.Results The highest incidence of decompensated hepatitis B cirrhosis was found in A blood group.There was no significant difference in the distribution of ABO blood group for patients with different age (P ＞ 0.05).Significant correlations were observed between AB blood group and family history of hepatitis B patients,expansion of the portal veines ＞ 1.5 cm,esophageal varices,cirrhosis complications,hepatic function classification (P ＜ 0.01).C ystatin C expression was increased with hepatic function classification (P ＜ 0.05).Conclusions The risk of liver cirrhosis is increased in patients with A blood group.Compare with other blood group,patients with AB blood group has a serious progression.The level of nitrogen,creatinine,cystatin C in decompensated cirrhosis are significantly higher than healthy controls.The level of cystatin C expression is increased with hepatic function classification.Cystatin C may be a potential marker in the classification of hepatic function.