中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
28期
1-4
,共4页
朱春燕%孙继军%申变红%江长旺%陶云海%施剑飞
硃春燕%孫繼軍%申變紅%江長旺%陶雲海%施劍飛
주춘연%손계군%신변홍%강장왕%도운해%시검비
代谢综合征%精神分裂症%认知%事件相关电位%韦氏记忆量表
代謝綜閤徵%精神分裂癥%認知%事件相關電位%韋氏記憶量錶
대사종합정%정신분렬증%인지%사건상관전위%위씨기억량표
Metabolic syndrome%Schizophrenia%Cognition%Event-related potentials%Wechsler memory scale
目的 探讨伴有与不伴有代谢综合征首发精神分裂症患者认知功能的差别.方法 对57例伴有代谢综合征的首发精神分裂症患者(研究组)和57例不伴有代谢综合征的首发精神分裂症患者(对照组)进行事件相关电位检测和韦氏记忆量表(WMS)测定,并应用阳性和阴性症状量表(PANSS)对两组进行精神病理学评定.结果 记忆商数研究组(78.51±12.54)分,对照组(92.01±17.49)分,两组差异有统计学意义(t=-2.130、P=0.047),研究组短时记忆、瞬时记忆受损均高于对照组(t=2.151 ～ 3.054、P=0.007～0.046);P300潜伏期研究组(325.10±22.46)ms,对照组(284.60±22.46)ms,两组差异有统计学意义(t=3.454、P=0.003),P300波幅研究组(6.56±1.61)μV,对照组(9.78±1.73) μV,差异有统计学意义(t=-4.307、P=0.000).结论 伴有代谢综合征的首发精神分裂症患者比不伴有代谢综合征的首发精神分裂症患者存在更严重的认知功能损害.
目的 探討伴有與不伴有代謝綜閤徵首髮精神分裂癥患者認知功能的差彆.方法 對57例伴有代謝綜閤徵的首髮精神分裂癥患者(研究組)和57例不伴有代謝綜閤徵的首髮精神分裂癥患者(對照組)進行事件相關電位檢測和韋氏記憶量錶(WMS)測定,併應用暘性和陰性癥狀量錶(PANSS)對兩組進行精神病理學評定.結果 記憶商數研究組(78.51±12.54)分,對照組(92.01±17.49)分,兩組差異有統計學意義(t=-2.130、P=0.047),研究組短時記憶、瞬時記憶受損均高于對照組(t=2.151 ～ 3.054、P=0.007～0.046);P300潛伏期研究組(325.10±22.46)ms,對照組(284.60±22.46)ms,兩組差異有統計學意義(t=3.454、P=0.003),P300波幅研究組(6.56±1.61)μV,對照組(9.78±1.73) μV,差異有統計學意義(t=-4.307、P=0.000).結論 伴有代謝綜閤徵的首髮精神分裂癥患者比不伴有代謝綜閤徵的首髮精神分裂癥患者存在更嚴重的認知功能損害.
목적 탐토반유여불반유대사종합정수발정신분렬증환자인지공능적차별.방법 대57례반유대사종합정적수발정신분렬증환자(연구조)화57례불반유대사종합정적수발정신분렬증환자(대조조)진행사건상관전위검측화위씨기억량표(WMS)측정,병응용양성화음성증상량표(PANSS)대량조진행정신병이학평정.결과 기억상수연구조(78.51±12.54)분,대조조(92.01±17.49)분,량조차이유통계학의의(t=-2.130、P=0.047),연구조단시기억、순시기억수손균고우대조조(t=2.151 ～ 3.054、P=0.007～0.046);P300잠복기연구조(325.10±22.46)ms,대조조(284.60±22.46)ms,량조차이유통계학의의(t=3.454、P=0.003),P300파폭연구조(6.56±1.61)μV,대조조(9.78±1.73) μV,차이유통계학의의(t=-4.307、P=0.000).결론 반유대사종합정적수발정신분렬증환자비불반유대사종합정적수발정신분렬증환자존재경엄중적인지공능손해.
Objective To discuss the difference of cognitive function in patients of first-episode schizophrenia with and without metabolic syndrome.Methods Event related potential detection and Wechsler Memory Scale (WMS) was determined in 57 patients of first-episode schizophrenia with metabolic syndrome (research group) and 57 patients of first-episode schizophrenia without metabolic syndrome (control group),and the psychiatric symptom in two groups was assessed by the application of the positive and negative symptoms scale (PANSS).Results The memory quotient score was (78.51 ± 12.54) scores in research group,and (92.01 ± 17.49) scores in control group,and there was significant difference between two groups (t =-2.130,P=0.047).The short-term memory,instantaneous memory impairment in research group were lower than those in control group(t =2.151-3.054,P=0.007-0.046).The latency of P300 was (325.10 ±22.46) ms in research group and (284.60 ±22.46) ms in control group,and there was significant difference (t =3.454,P =0.003).The amplitude was (6.56 ± 1.61) μ V in research group and (9.78 ±1.73) μV in control group,and there was significant difference (t =-4.307,P =0.000).Conclusion The patients of first-episode schizophrenia with metabolism syndrome has more severe cognitive impairment than those without metabolism syndrome.
