CAJ | 학술논문

目的了解我国急性胰腺炎(AP)常见病因的特点及其与性别及病死率之间的关系.方法通过中国期刊全文数据库、万方数据库、维普数据库等数据库及论文集检索相关文献.依据检索策略收集资料,按纳入标准筛选文献,主要对胆源性、高脂血症性、酒精性等引起的AP从性别及病死率方面进行Meta分析.结果共纳入符合标准的11篇临床研究,涉及13 601例患者,其中胆源性AP6 732例,高脂血症性AP 1 372例,酒精性AP l 169例.Meta分析结果显示:胆源性AP男女比例为0.79∶1,高脂血症性AP男女比例为1.54∶1,酒精性AP男女比例为10.47∶1,暴饮暴食性AP男女比例为1.29∶1,且差异均有统计学意义(P＜0.05).酒精性AP病死率最高,是胆源性AP病死率的2.81倍,是高脂血症性AP病死率的2.46倍,且差异有统计学意义(P＜0.05).结论我国AP常见病因中,胆道疾病仍是主要病因,且女性略高一些,而其他常见病因中男性普遍高于女性.酒精性AP尤为突出,且酒精性AP病死率最高,但仍需要大规模的流行病学研究进一步证实.
목적 료해아국급성이선염(AP)상견병인적특점급기여성별급병사솔지간적관계.방법 통과중국기간전문수거고、만방수거고、유보수거고등수거고급논문집검색상관문헌.의거검색책략수집자료,안납입표준사선문헌,주요대담원성、고지혈증성、주정성등인기적AP종성별급병사솔방면진행Meta분석.결과 공납입부합표준적11편림상연구,섭급13 601례환자,기중담원성AP6 732례,고지혈증성AP 1 372례,주정성AP l 169례.Meta분석결과현시:담원성AP남녀비례위0.79∶1,고지혈증성AP남녀비례위1.54∶1,주정성AP남녀비례위10.47∶1,폭음폭식성AP남녀비례위1.29∶1,차차이균유통계학의의(P＜0.05).주정성AP병사솔최고,시담원성AP병사솔적2.81배,시고지혈증성AP병사솔적2.46배,차차이유통계학의의(P＜0.05).결론 아국AP상견병인중,담도질병잉시주요병인,차녀성략고일사,이기타상견병인중남성보편고우녀성.주정성AP우위돌출,차주정성AP병사솔최고,단잉수요대규모적류행병학연구진일보증실.
Objective To understand the characteristics of common causes of acute pancreatitis (AP) in China and evaluate the association of the aetiology with gender and mortality.Methods The relevant literature was searched by the China journal full-text database (CNKI),Wanfang database,Weipu database and other databases and proceeding.Based on collecting data retrieval strategy,according to the inclusion criteria selection literature,Meta analysis was performed mainly for gallstone,hyperlipidemia,alcohol and other AP from the aspects of gender and case fatality rate.Results The Meta analysis included 11 articles which were accordance with the criteria,involving 13 601 patients,including 6 732 cases of biliary AP,1 372 cases of hyperlipidemia AP and 1 169 cases of alcohol AP.The Meta analysis showed that biliary AP male to female ratio was 0.79 ∶ 1,hyperlipidemic AP male to female ratio was 1.54 ∶ 1,alcoholic AP male to female ratio was 10.47 ∶ 1,overeating AP male to female ratio was 1.29 ∶ 1,and there was significant difference (P ＜ 0.05).Alcoholic AP mortality rate was the highest,which was 2.81 times than the biliary AP and 2.46 times than the hyperlipemic AP,and there was significant difference (P ＜0.05).Conclusions Biliary tract disease is the main etiologic cause of AP in China,and there are more females than males.The mortality rate of alcoholic pancreatitis is the highest,and there are more males.But we should investigate further high-quality,large-scale trails in patients with AP.