中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
28期
52-55
,共4页
杨立斌%孟英杰%张妍%索旺生%李小倩
楊立斌%孟英傑%張妍%索旺生%李小倩
양립빈%맹영걸%장연%색왕생%리소천
可溶性P-选择素%氧化型低密度脂蛋白%代谢综合征X%颈动脉粥样硬化
可溶性P-選擇素%氧化型低密度脂蛋白%代謝綜閤徵X%頸動脈粥樣硬化
가용성P-선택소%양화형저밀도지단백%대사종합정X%경동맥죽양경화
Soluble P-selectin%Oxidized low density lipoprotein%Metabolic syndrome X%Carotid atherosclerosis
目的 探讨代谢综合征(MS)患者血清氧化型低密度脂蛋白(Ox-LDL)和可溶性P-选择素(SP-S)与颈动脉粥样硬化(CA)的关系及临床意义.方法 入选103例MS患者和44例健康体检者(对照组),MS患者中具有3项MS诊断条件者为低危组(51例),具有≥4项MS诊断条件者为高危组(52例).所有入选者应用彩色多普勒超声仪测定颈动脉内膜-中层厚度(IMT)和斑块,应用酶联免疫吸附法测定血清Ox-LDL、SP-S,并进行Pearson直线相关和二分类非条件Logistic回归分析.结果 低危组和高危组Ox-LDL、SP-S、颈动脉IMT明显高于对照组[(36.42±7.17) μg/L和(54.44±8.10)μg/L)比(30.08±7.15) μg/L、(71.46±12.52)μg/L和(89.33±20.28)μg/L比(49.95±12.49) μg/L、(0.86±0.11) mm和(1.00±0.10) mm比(0.69±0.11) mm],差异有统计学意义(P＜0.01).高危组和低危组斑块发生率明显高于对照组[55.8％(29/52)和45.1％(23/51)比15.9％(7/44)],差异有统计学意义(P＜0.01).Pearson直线相关分析结果显示,Ox-LDL与SP-S呈明显正相关(P＜0.01).结论 随着MS诊断条件的增加,血清Ox-LDL和SP-S升高,颈动脉IMT增厚,斑块发生率升高.血清Ox-LDL与SP-S呈明显正相关.
目的 探討代謝綜閤徵(MS)患者血清氧化型低密度脂蛋白(Ox-LDL)和可溶性P-選擇素(SP-S)與頸動脈粥樣硬化(CA)的關繫及臨床意義.方法 入選103例MS患者和44例健康體檢者(對照組),MS患者中具有3項MS診斷條件者為低危組(51例),具有≥4項MS診斷條件者為高危組(52例).所有入選者應用綵色多普勒超聲儀測定頸動脈內膜-中層厚度(IMT)和斑塊,應用酶聯免疫吸附法測定血清Ox-LDL、SP-S,併進行Pearson直線相關和二分類非條件Logistic迴歸分析.結果 低危組和高危組Ox-LDL、SP-S、頸動脈IMT明顯高于對照組[(36.42±7.17) μg/L和(54.44±8.10)μg/L)比(30.08±7.15) μg/L、(71.46±12.52)μg/L和(89.33±20.28)μg/L比(49.95±12.49) μg/L、(0.86±0.11) mm和(1.00±0.10) mm比(0.69±0.11) mm],差異有統計學意義(P＜0.01).高危組和低危組斑塊髮生率明顯高于對照組[55.8％(29/52)和45.1％(23/51)比15.9％(7/44)],差異有統計學意義(P＜0.01).Pearson直線相關分析結果顯示,Ox-LDL與SP-S呈明顯正相關(P＜0.01).結論 隨著MS診斷條件的增加,血清Ox-LDL和SP-S升高,頸動脈IMT增厚,斑塊髮生率升高.血清Ox-LDL與SP-S呈明顯正相關.
목적 탐토대사종합정(MS)환자혈청양화형저밀도지단백(Ox-LDL)화가용성P-선택소(SP-S)여경동맥죽양경화(CA)적관계급림상의의.방법 입선103례MS환자화44례건강체검자(대조조),MS환자중구유3항MS진단조건자위저위조(51례),구유≥4항MS진단조건자위고위조(52례).소유입선자응용채색다보륵초성의측정경동맥내막-중층후도(IMT)화반괴,응용매련면역흡부법측정혈청Ox-LDL、SP-S,병진행Pearson직선상관화이분류비조건Logistic회귀분석.결과 저위조화고위조Ox-LDL、SP-S、경동맥IMT명현고우대조조[(36.42±7.17) μg/L화(54.44±8.10)μg/L)비(30.08±7.15) μg/L、(71.46±12.52)μg/L화(89.33±20.28)μg/L비(49.95±12.49) μg/L、(0.86±0.11) mm화(1.00±0.10) mm비(0.69±0.11) mm],차이유통계학의의(P＜0.01).고위조화저위조반괴발생솔명현고우대조조[55.8％(29/52)화45.1％(23/51)비15.9％(7/44)],차이유통계학의의(P＜0.01).Pearson직선상관분석결과현시,Ox-LDL여SP-S정명현정상관(P＜0.01).결론 수착MS진단조건적증가,혈청Ox-LDL화SP-S승고,경동맥IMT증후,반괴발생솔승고.혈청Ox-LDL여SP-S정명현정상관.
Objective To explore the relationship and clinical significance between the serum levels of oxidized low density lipoprotein (Ox-LDL) and soluble P-selectin (SP-S),and carotid atherosclerosis (CA) in metabolic syndrome (MS) patients.Methods In 103 cases of MS patients and 44 healthy subjects (control group),in MS patients with 3 MS diagnostic criteria for the low risk group (51 cases),with ≥ 4 MS diagnostic criteria for high risk group (52 cases).Carotid artery intima-media thickness (IMT) and plaque was measured by color Doppler ultrasound,serum Ox-LDL,SP-S was determined by enzyme linked immunosorbent assay,and pearson regression analysis of linear correlation and classification of two non condition Logistic was performed.Results The serum levels of Ox-LDL,SP-S,carotid artery IMT in low risk group and high risk group were higher than those in control group [(36.42 ±7.17) μg/L and (54.44± 8.10) μg/Lvs.(30.08±7.15) μg/L,(71.46± 12.52) μ g/Land (89.33±20.28) μg/Lvs.(49.95 ± 12.49) μ g/L,(0.86 ± 0.11) mm and (1.00 ± 0.10) mm vs.(0.69 ± 0.11) mm],the difference was statistically significant (P ＜ 0.01).The incidence of plaque in high-risk group and low-risk group was significantly higher than that in control group [55.8％ (29/52) and 45.1％ (23/51) vs.15.9％ (7/44)],the difference was statistically significant (P ＜ 0.01).Linear correlation analysis results of Pearson display,Ox-LDL was positively correlated with SP-S (P ＜0.01).Conclusion Serum Ox-LDL and SP-S are independent risk factor for carotid atherosclerosis in MS patients,they can evaluate progression of carotid atherosclerosis in patients with MS.
