CAJ | 학술논문

目的探讨左乙拉西坦对部分性癫痫患者认知功能及情绪的影响.方法将62例部分性癫痫患者按随机数字表法分为卡马西平组(30例)和左乙拉西坦组(32例),卡马西平组给予卡马西平治疗,左乙拉西坦组给予左乙拉西坦治疗,两组于治疗前及治疗第4,8,12,16周采用蒙特利尔认知评估量表(MoCA)、焦虑自评量表(SAS)和抑郁自评量表(SDS)进行评估.结果两组治疗前和治疗第4周MoCA评分比较差异无统计学意义(P＞0.05);左乙拉西坦组治疗第8,12,16周MoCA评分优于卡马西平组[(22.6±2.1)分比(20.8±2.6)分、(23.5±2.7)分比(21.3±2.8)分、(24.6±4.7)分比(21.2±3.0)分],差异有统计学意义(P＜0.05).两组治疗前后SAS评分、SDS评分比较差异无统计学意义(P＞0.05).结论在部分性癫痫患者的药物治疗过程中,左乙拉西坦对患者认知功能的改善优于卡马西平,但对情绪的改善不明显.
목적 탐토좌을랍서탄대부분성전간환자인지공능급정서적영향.방법 장62례부분성전간환자안수궤수자표법분위잡마서평조(30례)화좌을랍서탄조(32례),잡마서평조급여잡마서평치료,좌을랍서탄조급여좌을랍서탄치료,량조우치료전급치료제4,8,12,16주채용몽특리이인지평고량표(MoCA)、초필자평량표(SAS)화억욱자평량표(SDS)진행평고.결과 량조치료전화치료제4주MoCA평분비교차이무통계학의의(P＞0.05);좌을랍서탄조치료제8,12,16주MoCA평분우우잡마서평조[(22.6±2.1)분비(20.8±2.6)분、(23.5±2.7)분비(21.3±2.8)분、(24.6±4.7)분비(21.2±3.0)분],차이유통계학의의(P＜0.05).량조치료전후SAS평분、SDS평분비교차이무통계학의의(P＞0.05).결론 재부분성전간환자적약물치료과정중,좌을랍서탄대환자인지공능적개선우우잡마서평,단대정서적개선불명현.
Objective To investigate the clinical influence about levetiracetam on cognitive function and emotional influence in the patients with partial epilepsy.Methods A total of 62 patients with partial epilepsy were divided into carbamazepine group (30 cases) and levetiracetam group (32 cases) by random digits table method,carbamazepine group was treated by carbamazepine while levetiracetam group was treated by levetiracetam.The patients were assessed before treatment and 4,8,12,16 weeks after treatment by the Montreal cognitive assessment scale (MoCA),self rating anxiety scale (SAS) and self rating depression scale (SDS).Results There was no significant difference in MoCA score between two groups before treatment and 4 weeks after treatment (P ＞ 0.05).MoCA score at 8,12,16 weeks after treatment in levetiracetam group was better than that in carbamazepine group [(22.6 ± 2.1) scores vs.(20.8 ± 2.6) scores,(23.5±2.7) scoresvs.(21.3± 2.8) scores,(24.6±4.7) scoresvs.(21.2±3.0) scores],the difference was statistically significant (P ＜ 0.05).There was no significant difference between SAS score,SDS score between two groups before and after treatment (P ＞ 0.05).Conclusion In the process of treating the patients with partial epilepsy by drug,levetiracetam is superior to carbamazepine on the improvement of cognitive function,but the mood improvement is not obvious.