中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
29期
13-15
,共3页
胸腺瘤%PTEN%Ki-67
胸腺瘤%PTEN%Ki-67
흉선류%PTEN%Ki-67
Thymoma%PTEN%Ki-67
目的 探讨PTEN和Ki-67与胸腺瘤WHO分型、Masaoka分期的关系及胸腺瘤中生物学表达的意义.方法 应用免疫组织化学S-P法,对52例胸腺瘤标本中PTEN和Ki-67的表达情况进行检测.结果 随着WHO分型和Masaoka分期的升高PTEN阳性表达比例均逐渐降低(8/10,10/14,6/12,4/11,O,0和10/13,12/20,6/16,O),差异均有统计学意义(x2=11.751,P=0.038;x2=8.311,P=0.040).随着WHO分型和Masaoka分期的升高Ki-67阳性表达比例均逐渐升高(1/10,6/14,6/12,8/11,2/3,2/2和3/13,9/20,10/16,3/3),差异均有统计学意义(x2=11.231,P=0.047;x2=7.904,P=0.048).Spearman等级相关分析结果显示,PTEN与Ki-67在胸腺瘤中表达呈负相关性(r=-0.422,P=0.002).结论 PTEN和Ki-67的阳性表达率与胸腺瘤的临床分型、分期等密切相关,检测PTEN和Ki-67的阳性表达有助于判断胸腺瘤生物学特征,从而对胸腺瘤的诊断、恶性程度、侵袭和转移能力提供帮助,为临床诊治提供客观指标.
目的 探討PTEN和Ki-67與胸腺瘤WHO分型、Masaoka分期的關繫及胸腺瘤中生物學錶達的意義.方法 應用免疫組織化學S-P法,對52例胸腺瘤標本中PTEN和Ki-67的錶達情況進行檢測.結果 隨著WHO分型和Masaoka分期的升高PTEN暘性錶達比例均逐漸降低(8/10,10/14,6/12,4/11,O,0和10/13,12/20,6/16,O),差異均有統計學意義(x2=11.751,P=0.038;x2=8.311,P=0.040).隨著WHO分型和Masaoka分期的升高Ki-67暘性錶達比例均逐漸升高(1/10,6/14,6/12,8/11,2/3,2/2和3/13,9/20,10/16,3/3),差異均有統計學意義(x2=11.231,P=0.047;x2=7.904,P=0.048).Spearman等級相關分析結果顯示,PTEN與Ki-67在胸腺瘤中錶達呈負相關性(r=-0.422,P=0.002).結論 PTEN和Ki-67的暘性錶達率與胸腺瘤的臨床分型、分期等密切相關,檢測PTEN和Ki-67的暘性錶達有助于判斷胸腺瘤生物學特徵,從而對胸腺瘤的診斷、噁性程度、侵襲和轉移能力提供幫助,為臨床診治提供客觀指標.
목적 탐토PTEN화Ki-67여흉선류WHO분형、Masaoka분기적관계급흉선류중생물학표체적의의.방법 응용면역조직화학S-P법,대52례흉선류표본중PTEN화Ki-67적표체정황진행검측.결과 수착WHO분형화Masaoka분기적승고PTEN양성표체비례균축점강저(8/10,10/14,6/12,4/11,O,0화10/13,12/20,6/16,O),차이균유통계학의의(x2=11.751,P=0.038;x2=8.311,P=0.040).수착WHO분형화Masaoka분기적승고Ki-67양성표체비례균축점승고(1/10,6/14,6/12,8/11,2/3,2/2화3/13,9/20,10/16,3/3),차이균유통계학의의(x2=11.231,P=0.047;x2=7.904,P=0.048).Spearman등급상관분석결과현시,PTEN여Ki-67재흉선류중표체정부상관성(r=-0.422,P=0.002).결론 PTEN화Ki-67적양성표체솔여흉선류적림상분형、분기등밀절상관,검측PTEN화Ki-67적양성표체유조우판단흉선류생물학특정,종이대흉선류적진단、악성정도、침습화전이능력제공방조,위림상진치제공객관지표.
Objective To investigate the relationship of PTEN,Ki-67,type of credits of thymoma in WHO organization and Masaoka staging,and the significance of the biology's expression in thymoma.Methods The expression of PTEN and Ki-67 in 52 pieces of thymoma specimens was detected by the method of immunohistochemical SP.Results Positive expression rate of the 52 patients with thymoma was decreased gradually after WHO classification (8/10,10/14,6/12,4/11,0,0 and 10/13,12/20,6/16,0),Masaoka staging and PTEN.The difference were significant in statistics (λ2 =11.751,P =0.038 ; x2 =8.311,P =0.040).Positive expression rate of Ki-67 was gradually increased (1/10,6/14,6/12,8/11,2/3,2/2 and 3/13,9/20,10/16,3/3),the difference was also significant in statistics (x2 =11.231,P =0.047; x2 =7.904,P =0.048).Conclusions The positive expression rate of PTEN,Ki-67 are both related to clinical classification and staging closely.The detection to the positive expression rate of PTEN and Ki-67 can contribute to judging thymoma biological characteristics,thus,it will be helpful in diagnosing the thymoma,analyzing the degree of malignancy,invading and transferring ability.And then provide objective indicators for clinical diagnosis and treatment.
