中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
30期
50-53
,共4页
流产,先兆%妊娠相关血浆蛋白A%妊娠结局
流產,先兆%妊娠相關血漿蛋白A%妊娠結跼
유산,선조%임신상관혈장단백A%임신결국
Abortion,threatened%Pregnancy-associated plasma protein-A%Pregnancy outcome
目的 分析妊娠相关血浆蛋白A (PAPP-A)水平与先兆流产的关系,探讨孕早期低水平的PAPP-A是否可作为预测妊娠结局的指标.方法 采用双抗体夹心酶联免疫法检测1 10例先兆流产孕妇(先兆流产组)与131例正常宫内早孕孕妇(对照组)血清PAPP-A水平,并追踪至孕20周.结果 对照组血清PAPP-A的中位数倍数(MOM)值为1.02±0.15,先兆流产组为0.98±0.17,两组比较差异无统计学意义(P＞0.05).在先兆流产组中,保胎成功90例,PAPP-A的MOM值为1.03±0.11,保胎失败20例,PAPP-A的MOM值为0.73±0.21,两者比较差异有统计学意义(P＜0.01).而对照组与先兆流产组保胎成功患者PAPP-A的MOM值比较差异无统计学意义(P＞0.05).结论 PAPP-A水平与胚胎生长发育是否良好密切相关,可作为先兆流产孕妇预测流产结局的评价指标之一.
目的 分析妊娠相關血漿蛋白A (PAPP-A)水平與先兆流產的關繫,探討孕早期低水平的PAPP-A是否可作為預測妊娠結跼的指標.方法 採用雙抗體夾心酶聯免疫法檢測1 10例先兆流產孕婦(先兆流產組)與131例正常宮內早孕孕婦(對照組)血清PAPP-A水平,併追蹤至孕20週.結果 對照組血清PAPP-A的中位數倍數(MOM)值為1.02±0.15,先兆流產組為0.98±0.17,兩組比較差異無統計學意義(P＞0.05).在先兆流產組中,保胎成功90例,PAPP-A的MOM值為1.03±0.11,保胎失敗20例,PAPP-A的MOM值為0.73±0.21,兩者比較差異有統計學意義(P＜0.01).而對照組與先兆流產組保胎成功患者PAPP-A的MOM值比較差異無統計學意義(P＞0.05).結論 PAPP-A水平與胚胎生長髮育是否良好密切相關,可作為先兆流產孕婦預測流產結跼的評價指標之一.
목적 분석임신상관혈장단백A (PAPP-A)수평여선조유산적관계,탐토잉조기저수평적PAPP-A시부가작위예측임신결국적지표.방법 채용쌍항체협심매련면역법검측1 10례선조유산잉부(선조유산조)여131례정상궁내조잉잉부(대조조)혈청PAPP-A수평,병추종지잉20주.결과 대조조혈청PAPP-A적중위수배수(MOM)치위1.02±0.15,선조유산조위0.98±0.17,량조비교차이무통계학의의(P＞0.05).재선조유산조중,보태성공90례,PAPP-A적MOM치위1.03±0.11,보태실패20례,PAPP-A적MOM치위0.73±0.21,량자비교차이유통계학의의(P＜0.01).이대조조여선조유산조보태성공환자PAPP-A적MOM치비교차이무통계학의의(P＞0.05).결론 PAPP-A수평여배태생장발육시부량호밀절상관,가작위선조유산잉부예측유산결국적평개지표지일.
Objective To explore the relationship between pregnancy associated plasma protein A (PAPP-A) and threatened abortion,whether low level of PAPP-A in early pregnancy can be used as indicators to predict the pregnancy outcomes.Methods The level of serum PAPP-A was measured by double antibody sandwich enzyme-linked immunosorbent assay in 110 cases with threatened abortion (threatened abortion group) and 131 cases with normal intrauterine pregnancy (control group),and track to 20 weeks pregnant.Results The serum PAPP-A multiple of median (MOM) value was 1.02 ± 0.15 in control group,0.98 ± 0.17 in threatened abortion group,and there was no significant difference(P ＞ 0.05).In threatened abortion group,90 cases of spuc success,the serum PAPP-A MOM value was 1.03 ± 0.11,20 patients of spuc failure,the serum PAPP-A MOM value was 0.73±0.21,and there was significant difference (P ＜ 0.01).There was no significant difference in the serum PAPP-A MOM value between control group and the spuc success of threatened abortion group (P ＞ 0.05).Conclusion Pregnant women with PAPP-A levels embryonic development is closely related to the good,as one can predict miscarriage in pregnant women with threatened abortion outcome evaluation.
