CAJ | 학술논문

2例患者(例1男性,32岁;例2女性,27岁),应用抗结核药物治疗期间肝功能均正常,因尿酸水平升高加用别嘌醇0.1g,3次/d口服.2周后出现发热、皮疹.实验室检查:例1丙氨酸转氨酶(ALT) 1182 U/L,天冬氨酸转氨酶(AST) 595 U/L,总胆红素25.9 mmol/L;例2 ALT 1452 U/L,AST 1942 U/L.停用别嘌醇及抗结核药,接受保肝治疗.2例患者肝功能分别于治疗后14、25 d后基本恢复正常.例1继续抗结核治疗,随访4个月肝功能正常.例2因病情稳定停止抗结核治疗.
2례환자(례1남성,32세;례2녀성,27세),응용항결핵약물치료기간간공능균정상,인뇨산수평승고가용별표순0.1g,3차/d구복.2주후출현발열、피진.실험실검사:례1병안산전안매(ALT) 1182 U/L,천동안산전안매(AST) 595 U/L,총담홍소25.9 mmol/L;례2 ALT 1452 U/L,AST 1942 U/L.정용별표순급항결핵약,접수보간치료.2례환자간공능분별우치료후14、25 d후기본회복정상.례1계속항결핵치료,수방4개월간공능정상.례2인병정은정정지항결핵치료.
Two patients,a 32-year-old man and a 27-year-old woman,had normal liver function during antituberculous treatment.Oral allopurinol 0.1 g thrice daily was added to their regimen due to hyperuricemia.They developed fever and rash after 2 weeks.Laboratory tests showed the following values:alanine transaminase (ALT) 1182 U/L,aspartate transaminase (AST) 595 U/L,total bilirubin 25.9mmol/L in patient 1 ; ALT 1452 U/L,AST 1942 U/L in patient 2.Allopurinol and the antituberculous drugs were discontinued.Both patients received liver-protective treatment.The results of their liver function tests basically returned to normal on days 14 and 25 of treatment,respectively.In patient 1 antituberculous treatment was continued,he had the normal liver function during 4 months of follow-up.In patient 2antituberculous treatment was stopped because of the stable condition.