药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2013年
5期
298-300
,共3页
何首乌%肝功能不全%中性粒细胞减少
何首烏%肝功能不全%中性粒細胞減少
하수오%간공능불전%중성립세포감소
Polygonum multiflorum%Hepatic insufficiency%Neutropenia
1例20岁女性为乌发自行服用何首乌粉15g/d.2周后,患者出现纳差及乏力;3周后出现尿色加深,肝功能检查示天冬氨酸转氨酶(AST)878 U/L,丙氨酸转氨酶(ALT) 1121 U/L,总胆红素(TBil) 100.8 μmol/L,直接胆红素(DBil T)77.4 μmol/L.服用何首乌粉第42天,实验室检查:AST472 U/L,ALT 755 U/L,TBil 102.9 μmol/L,DBil 76.7 μmol/L;白细胞计数3.2×109/L,中性粒细胞计数0.27×109/L.考虑药物引起肝损害和中性粒细胞缺乏可能性大.停用何首乌,给予保肝、退黄等综合治疗.治疗10 d后实验室检查:ALT 62 U/L,AST 73 U/L,DBil 20.5μmol/L,TBil 30.2 μmol/L;白细胞计数6.2×109/L,中性粒细胞计数3.60×109/L.
1例20歲女性為烏髮自行服用何首烏粉15g/d.2週後,患者齣現納差及乏力;3週後齣現尿色加深,肝功能檢查示天鼕氨痠轉氨酶(AST)878 U/L,丙氨痠轉氨酶(ALT) 1121 U/L,總膽紅素(TBil) 100.8 μmol/L,直接膽紅素(DBil T)77.4 μmol/L.服用何首烏粉第42天,實驗室檢查:AST472 U/L,ALT 755 U/L,TBil 102.9 μmol/L,DBil 76.7 μmol/L;白細胞計數3.2×109/L,中性粒細胞計數0.27×109/L.攷慮藥物引起肝損害和中性粒細胞缺乏可能性大.停用何首烏,給予保肝、退黃等綜閤治療.治療10 d後實驗室檢查:ALT 62 U/L,AST 73 U/L,DBil 20.5μmol/L,TBil 30.2 μmol/L;白細胞計數6.2×109/L,中性粒細胞計數3.60×109/L.
1례20세녀성위오발자행복용하수오분15g/d.2주후,환자출현납차급핍력;3주후출현뇨색가심,간공능검사시천동안산전안매(AST)878 U/L,병안산전안매(ALT) 1121 U/L,총담홍소(TBil) 100.8 μmol/L,직접담홍소(DBil T)77.4 μmol/L.복용하수오분제42천,실험실검사:AST472 U/L,ALT 755 U/L,TBil 102.9 μmol/L,DBil 76.7 μmol/L;백세포계수3.2×109/L,중성립세포계수0.27×109/L.고필약물인기간손해화중성립세포결핍가능성대.정용하수오,급여보간、퇴황등종합치료.치료10 d후실험실검사:ALT 62 U/L,AST 73 U/L,DBil 20.5μmol/L,TBil 30.2 μmol/L;백세포계수6.2×109/L,중성립세포계수3.60×109/L.
A 20-year-old woman took herbal medicine Polygonum multiflorum powder 15 g/d by herself for blacking hair.Two weeks later,the patient presented with poor appetite and fatigue and,three weeks later,she experienced yellowish urine and liver function tests showed the following values:aspartate transaminase (AST) 878 U/L,alanine aminotransferase (ALT) 1121 U/L,total bilirubin (TBil) 100.8 μmol/L,direct bilirubin (DBil) 77.4 μmol/L.On day 42 of using Polygonum multiflorum powder,laboratory test revealed the following levels:AST 472 U/L,ALT 755 U/L,TBil 102.9 μmol/L,DBil 76.7 μmol/L,WBC count 3.2 × 109/L,neutrophil count 0.27 × 109/L.Liver damage and agranulocytosis were considered to be probably produced by the medicine.Polygonum multiflorum was withdrawn and liverprotective medications were used to treat jaundice,and other comprehensive therapy were given.Ten days after treatment,laboratory test revealed the following levels:ALT 62 U/L,AST 73 U/L,DBil 20.5 μmol/L,TBil 30.2 μmol/L,WBC count 6.2 × 109/L,neutrophil count 3.60 × 109/L.
