CAJ | 학술논문

l例58岁女性2型糖尿病患者应用盐酸二甲双胍(0.5g,2次/d口服)及胰岛素(三餐前分别皮下注射胰岛素8、8、10 U,睡前皮下注射甘精胰岛素8U)治疗,因效果不佳加用西格列汀(100 mg,1次/d口服).3周后,患者出现恶心、呕吐伴腹痛.实验室检查:血清淀粉酶499 U/L,尿淀粉酶933 U/L.腹部超声检查示腹腔积液.诊断为急性胰腺炎.停用西格列汀、盐酸二甲双胍,继续应用胰岛素,并给予抑酸、抑酶、补液等治疗.6d后,患者病情好转,血清淀粉酶76 U/L,尿淀粉酶288 U/L.
l례58세녀성2형당뇨병환자응용염산이갑쌍고(0.5g,2차/d구복)급이도소(삼찬전분별피하주사이도소8、8、10 U,수전피하주사감정이도소8U)치료,인효과불가가용서격렬정(100 mg,1차/d구복).3주후,환자출현악심、구토반복통.실험실검사:혈청정분매499 U/L,뇨정분매933 U/L.복부초성검사시복강적액.진단위급성이선염.정용서격렬정、염산이갑쌍고,계속응용이도소,병급여억산、억매、보액등치료.6d후,환자병정호전,혈청정분매76 U/L,뇨정분매288 U/L.
A 58-year-old female patient with type 2 diabetes mellitus treated with metformin hydrochloride (0.5 g twice daily)and insulin (subcutaneous of injection insulin 8、8、10 U before three meals respectively and subcutaneous injection of insulin glargine 8 U before sleep).Sitagliptin 100 mg once daily was added to her regimen due to unsatisfactory efficacy.Three weeks later,the patients felt nausea,vomiting and abdominal pain.Laboratory examination showed a serum amylase value of 267 U/L and urine amylase value of 933 U/L.Abdominal ultrasonography revealed seroperitoneum.She was diagnosed as having acute pancreatitis.Sitagliptin and metformin hydrochloride were withdrawn and insulin was continued.Symptomatic treatment such as acid suppression,inhibition of digestive enzyme and fluid supplement were given.Six days later,the patient's condition improved,the levels of serum amylase and urine amylase were 76 U/L and 288 U/L,respectively.