CAJ | 학술논문

目的分析上海市浦东新区胰腺癌发病、死亡及生存情况.方法利用2002年至2010年浦东新区居民胰腺癌的登记资料,分性别组和年龄组计算发病率、死亡率.用世界标准人口计算标化率,采用对数直线回归法估算发病率及死亡率的年度百分比变化(APC),应用Kaplan-Meier法和COX多元回归模型计算患者1～5年生存率,分析不同TNM分期和是否手术的胰腺癌患者的生存情况.结果 2002年至2010年上海市浦东新区胰腺癌新发患者3089例,其中男性1707例,女性1382例,平均发病年龄分别为(69±12)岁和(73±12)岁；合计粗发病率为13.32/10万,其中男性粗发病率为14.71/10万,高于女性的11.93/10万,男女性标化发病率之比为1.57:1.胰腺癌患者死亡2963例,其中男性1627例,女性1336例,合计粗死亡率为12.78/10万,其中男性为14.02/10万,高于女性的11.53/10万,男女性标化死亡率之比为1.55:1.男性在35岁、女性在40岁以后发病率和死亡率均明显升高,男性80岁以上、女性85岁以上发病率和死亡率达到高峰.胰腺癌患者1～5年生存率分别为16.59％、7.31％、5.23％、4.33％和3.87％.手术治疗组1～5年生存率均高于非手术组,差异有统计学意义(P值均＜0.05).TNM分期为0～Ⅱ期、Ⅲ期、Ⅳ期患者的中位生存时间分别为(250.00±33.37)、(224.00±15.82)、(86.00±4.52)d.Ⅳ期患者与0～Ⅱ期及Ⅲ期患者生存时间的差异均有统计学意义(X2值分别为72.41、104.40,P值均＜0.001).结论上海市浦东新区男性胰腺癌发病率和死亡率均高于女性.患者的生存时间与确诊时的TNM分期及是否手术切除肿瘤有关.
목적 분석상해시포동신구이선암발병、사망급생존정황.방법 이용2002년지2010년포동신구거민이선암적등기자료,분성별조화년령조계산발병솔、사망솔.용세계표준인구계산표화솔,채용대수직선회귀법고산발병솔급사망솔적년도백분비변화(APC),응용Kaplan-Meier법화COX다원회귀모형계산환자1～5년생존솔,분석불동TNM분기화시부수술적이선암환자적생존정황.결과 2002년지2010년상해시포동신구이선암신발환자3089례,기중남성1707례,녀성1382례,평균발병년령분별위(69±12)세화(73±12)세；합계조발병솔위13.32/10만,기중남성조발병솔위14.71/10만,고우녀성적11.93/10만,남녀성표화발병솔지비위1.57:1.이선암환자사망2963례,기중남성1627례,녀성1336례,합계조사망솔위12.78/10만,기중남성위14.02/10만,고우녀성적11.53/10만,남녀성표화사망솔지비위1.55:1.남성재35세、녀성재40세이후발병솔화사망솔균명현승고,남성80세이상、녀성85세이상발병솔화사망솔체도고봉.이선암환자1～5년생존솔분별위16.59％、7.31％、5.23％、4.33％화3.87％.수술치료조1～5년생존솔균고우비수술조,차이유통계학의의(P치균＜0.05).TNM분기위0～Ⅱ기、Ⅲ기、Ⅳ기환자적중위생존시간분별위(250.00±33.37)、(224.00±15.82)、(86.00±4.52)d.Ⅳ기환자여0～Ⅱ기급Ⅲ기환자생존시간적차이균유통계학의의(X2치분별위72.41、104.40,P치균＜0.001).결론 상해시포동신구남성이선암발병솔화사망솔균고우녀성.환자적생존시간여학진시적TNM분기급시부수술절제종류유관.
Objective To analyze the incidence,mortality and survival rates of pancreatic cancer in Pudong New Area of Shanghai from 2002 to 2010.Methods The residents in Pudong New Area of Shanghai were recruited in this study during the period 2002 ～ 2010,the incidence,mortality were calculated according to different age groups and genders.The standardized morbidity and mortality of pancreatic cancer were calculated by world standard population.Logarithmic linear regression was used to calculate the annual percentage change (APC) of incidence and mortality.The 1 ～ 5 year survival of pancreatic cancer patients was analyzed by Kaplan-Meier method and COX regression analysis,and the survival of patients with different TNM staging,with or without operation was determined.Results Among 3089 newly occurred pancreatic cancer cases during 2002 ～ 2010,1707 and 1382 cases were males and females,respectively,with an average age of (69 ± 12) and (73 ± 12) years old,the crude incidence for both genders was 13.32/100 000,and it was 14.71/100 000 for males,which was higher than that in females (11.93/100 000).The ratio of male and female for incidence of age standardize was 1.57:1.There were 2963 death in total,including 1627 males and 1336 females,with a crude mortality rate of 12.78/100 000.The crude mortality rate for males was 14.02/100 000,which was higher than that in females (11.53/100 000).The ratio of male and female ASR for mortality was 1.55:1.Both incidence and mortality significantly increased for males aged over 35 and females aged over 40.The peak of morbidity and mortality appeared in male over 80 years old,and in female over 85 years old.The 1 ～ 5 year survival rates of pancreatic cancer patients were 16.59％,7.31％,5.23％,4.33％ and 3.87％,respectively.The differences in 1 ～5 year survival rates between surgical and non-surgical management groups were statistically significant (P ＜ 0.05).The median survival time of TNM 0 ～ Ⅱ,Ⅲ and Ⅳ staging was (250.00 ± 33.37),(224.00 ± 15.82),(86.00 ± 4.52) d.There was a statistically significant difference among the survival of TNM-Ⅳ and TNM 0 ～ Ⅰ,TNM Ⅲ (P ＜ 0.001).Conclusions The incidence and mortality of pancreatic cancer in males are higher than those in females in Pudong New Area of Shanghai.The survival is associated with TNM staging at diagnosis and whether surgical operation is performed.