CAJ | 학술논문

目的探讨尿激活素A与新生儿缺氧缺血性脑病(HIE)的关系.方法选择50例足月缺氧缺血性脑病新生儿作为观察组,随机选择48例同期出生健康足月新生儿为健康对照组.生后7d内根据新生儿缺氧缺血性脑病诊断标准和临床分度,将50例窒息新生儿分成轻度HIE组30例、中重度HIE组20例.采用ELISA方法检测两组新生儿生后不同时间(2、12、24、48、72 h)尿激活素A的含量.结果中重度HIE组尿激活素A含量显著高于健康对照组(P＜0.01)和轻度HIE组(P＜0.01);健康对照组和轻度HIE组尿激活素A含量差异无统计学意义(P＞0.05).以尿激活素A含量＞70 ng/L为临界值判断中重度HIE发生,2h尿激活素A含量的敏感度为86％、特异度为99％;12～72 h尿激活素A含量的敏感度为100％、特异度为98％.结论尿激活素A含量与HIE病情程度呈正相关,对判断中重度HIE的发生有高度的敏感性及特异性,为诊断中重度HIE提供重要依据.
목적 탐토뇨격활소A여신생인결양결혈성뇌병(HIE)적관계.방법 선택50례족월결양결혈성뇌병신생인작위관찰조,수궤선택48례동기출생건강족월신생인위건강대조조.생후7d내근거신생인결양결혈성뇌병진단표준화림상분도,장50례질식신생인분성경도HIE조30례、중중도HIE조20례.채용ELISA방법검측량조신생인생후불동시간(2、12、24、48、72 h)뇨격활소A적함량.결과 중중도HIE조뇨격활소A함량현저고우건강대조조(P＜0.01)화경도HIE조(P＜0.01);건강대조조화경도HIE조뇨격활소A함량차이무통계학의의(P＞0.05).이뇨격활소A함량＞70 ng/L위림계치판단중중도HIE발생,2h뇨격활소A함량적민감도위86％、특이도위99％;12～72 h뇨격활소A함량적민감도위100％、특이도위98％.결론 뇨격활소A함량여HIE병정정도정정상관,대판단중중도HIE적발생유고도적민감성급특이성,위진단중중도HIE제공중요의거.
Objective To explore the relationship between urinary activin A and neonatal hypoxic-ischemic encephalopathy(HIE).Methods 50 full-term neonatal with HIE were selected as the observation group,48 normal full-term neonatal in the same period were selected as the normal control group randomly.Within 7 days after birth,the observation group was divided into the group of 30 patients with mild HIE and the group of 20 patients with moderate and severe HIE,according to diagnostic criteria and clinical grading of neonatal HIE.The levels of urinary activin A in two groups after birth at different time(2,12,24,48,72h)was determined by using ELISA method.Results The levels of urinary activin A in moderate and severe HIE group was significantly higher than than in the normal control group(P＜0.01)and mild HIE group(P＜0.01);The levels of urinary activin A in the normal control group and mild HIE group showed no significant differences(P＞0.05).Urinary activin A level＞70 ng/L for the critical value to determine the occurrence of moderate and severe HIE,the sensitivity and specificity of 2 h urinary activin A levels were separately 86％ and 99％;The sensitivity and specificity of 12～72 h urinary activin A levels were separately 100％ and 98％.Conclusion The correlation between the level of urinary activin A and the severity of HIE was positive,the level of urinary activin A had a high degree of sensitivity and specificity for determine the incidence of moderate and severe HIE,it provided an important basis for diagnosis of moderate and severe HIE.