中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
23期
3537-3538
,共2页
颅脑损伤%炎性因子%神经丝蛋白H磷酸化亚型%神经元特异性烯醇化酶
顱腦損傷%炎性因子%神經絲蛋白H燐痠化亞型%神經元特異性烯醇化酶
로뇌손상%염성인자%신경사단백H린산화아형%신경원특이성희순화매
Acute brain injury%Inflammafory factors%pNF-H%NSE
目的 探讨急性颅脑损伤患者白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、细胞间黏附分子1(ICAM-1)与神经丝蛋白H磷酸化亚型(pNF-H)及神经元特异性烯醇化酶(NSE)水平的变化和意义.方法 选择急性颅脑损伤患者100例作为观察组,按损伤程度分组(轻、中、重型组),检测血清IL-6、TNF-α、ICAM-1与pNF-H、NSE水平,并与30例健康对照组比较.结果 患者IL-6、TNF-α、ICAM-1与pNF-H、NSE水平均高于健康对照组(均P＜0.05);轻、中、重型颅脑损伤患者上述指标水平差异均有统计学意义(均P＜0.05);IL-6、TNF-α、ICAM-1与pNF-H、NSE水平均呈正相关(均P＜0.05).结论 IL-6、TNF-α、ICAM-1与pNF-H、NSE在急性颅脑损伤的病理过程中起到重要作用,其水平与病情严重程度密切相关.
目的 探討急性顱腦損傷患者白細胞介素6(IL-6)、腫瘤壞死因子α(TNF-α)、細胞間黏附分子1(ICAM-1)與神經絲蛋白H燐痠化亞型(pNF-H)及神經元特異性烯醇化酶(NSE)水平的變化和意義.方法 選擇急性顱腦損傷患者100例作為觀察組,按損傷程度分組(輕、中、重型組),檢測血清IL-6、TNF-α、ICAM-1與pNF-H、NSE水平,併與30例健康對照組比較.結果 患者IL-6、TNF-α、ICAM-1與pNF-H、NSE水平均高于健康對照組(均P＜0.05);輕、中、重型顱腦損傷患者上述指標水平差異均有統計學意義(均P＜0.05);IL-6、TNF-α、ICAM-1與pNF-H、NSE水平均呈正相關(均P＜0.05).結論 IL-6、TNF-α、ICAM-1與pNF-H、NSE在急性顱腦損傷的病理過程中起到重要作用,其水平與病情嚴重程度密切相關.
목적 탐토급성로뇌손상환자백세포개소6(IL-6)、종류배사인자α(TNF-α)、세포간점부분자1(ICAM-1)여신경사단백H린산화아형(pNF-H)급신경원특이성희순화매(NSE)수평적변화화의의.방법 선택급성로뇌손상환자100례작위관찰조,안손상정도분조(경、중、중형조),검측혈청IL-6、TNF-α、ICAM-1여pNF-H、NSE수평,병여30례건강대조조비교.결과 환자IL-6、TNF-α、ICAM-1여pNF-H、NSE수평균고우건강대조조(균P＜0.05);경、중、중형로뇌손상환자상술지표수평차이균유통계학의의(균P＜0.05);IL-6、TNF-α、ICAM-1여pNF-H、NSE수평균정정상관(균P＜0.05).결론 IL-6、TNF-α、ICAM-1여pNF-H、NSE재급성로뇌손상적병리과정중기도중요작용,기수평여병정엄중정도밀절상관.
Objective To explore the expression and significance of ser(u)m IL-6,TNF-α,ICAM-1,pNF-H and NSE in patients with acute brain injury.Methods 100 patients with acute brain injury were selected and divided into different groups(mild injury,moderate injury,severe injury).The serum levels of IL-6,TNF-α,ICAM-1,pNF-H and NSE were detected.30 healthy persons were selected as healthy control group.Results The serum IL-6,TNF-α,ICAM-1,pNF-H and NSE levels in the patients were higher than those in the healthy control groups(all P＜0.05).The serum levels of them were increased steply with the order of severity(all P＜0.05).IL-6,TNF-α,ICAM-1 were positive correlated with pNF-H and NSE(all P＜0.05).Conclusion The serum levels of IL-6,TNF-α,ICAM-1,pNF-H and NSE were correlated with degree of injury severity.The measurement of them may contribute to predict the severity of brain injury.
