中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
24期
3687-3688
,共2页
前降钙素%败血症%婴儿,新生
前降鈣素%敗血癥%嬰兒,新生
전강개소%패혈증%영인,신생
Procalcitionin%Septicemia%Infant,new born
目的 探讨血清前降钙素(PCT)检测在新生儿败血症诊疗中的应用价值.方法 75例新生儿败血症患儿为观察组,74例无感染征象的新生儿为对照组,入院时进行PCT、C-反应蛋白(CRP)、血常规和血培养检查,其中观察组在治疗1周后复查PTC和CRP.并对结果进行分析.结果 观察组入院时血CRP、PTC水平分别为(23.26±5.68)mg/L、(7.61±4.53)ng/L,明显高于对照组的(6.42±4.54)mg/L、(0.45±0.16)ng/L(t=19.97、14.08,均P＜0.01);治疗1周后,观察组CRP、PTC水平分别为(4.09±1.09)mg/L、(1.95±0.25)ng/L,治疗前后差异均有统计学意义(t=28.71、12.92,均P＜0.01).观察组入院时PTC阳性率82.7％、CRP阳性率48.0％、血培养阳性率28.0％,PTC与CRP阳性率差异有统计学意义(x2=5.64,P＜0.05),PTC与血培养阳性率差异有统计学意义(x2=10.40,P＜0.01).PTC检测以2.5 μg/L为临界点,对败血症的诊断敏感度是82.7％,特异度是80.3％.CRP检测以8 mg/L为临界点,对败血症诊断的敏感度是48.7％,特异度是78.4％.结论 PTC可作为新生儿败血症早期诊断有价值的指标.
目的 探討血清前降鈣素(PCT)檢測在新生兒敗血癥診療中的應用價值.方法 75例新生兒敗血癥患兒為觀察組,74例無感染徵象的新生兒為對照組,入院時進行PCT、C-反應蛋白(CRP)、血常規和血培養檢查,其中觀察組在治療1週後複查PTC和CRP.併對結果進行分析.結果 觀察組入院時血CRP、PTC水平分彆為(23.26±5.68)mg/L、(7.61±4.53)ng/L,明顯高于對照組的(6.42±4.54)mg/L、(0.45±0.16)ng/L(t=19.97、14.08,均P＜0.01);治療1週後,觀察組CRP、PTC水平分彆為(4.09±1.09)mg/L、(1.95±0.25)ng/L,治療前後差異均有統計學意義(t=28.71、12.92,均P＜0.01).觀察組入院時PTC暘性率82.7％、CRP暘性率48.0％、血培養暘性率28.0％,PTC與CRP暘性率差異有統計學意義(x2=5.64,P＜0.05),PTC與血培養暘性率差異有統計學意義(x2=10.40,P＜0.01).PTC檢測以2.5 μg/L為臨界點,對敗血癥的診斷敏感度是82.7％,特異度是80.3％.CRP檢測以8 mg/L為臨界點,對敗血癥診斷的敏感度是48.7％,特異度是78.4％.結論 PTC可作為新生兒敗血癥早期診斷有價值的指標.
목적 탐토혈청전강개소(PCT)검측재신생인패혈증진료중적응용개치.방법 75례신생인패혈증환인위관찰조,74례무감염정상적신생인위대조조,입원시진행PCT、C-반응단백(CRP)、혈상규화혈배양검사,기중관찰조재치료1주후복사PTC화CRP.병대결과진행분석.결과 관찰조입원시혈CRP、PTC수평분별위(23.26±5.68)mg/L、(7.61±4.53)ng/L,명현고우대조조적(6.42±4.54)mg/L、(0.45±0.16)ng/L(t=19.97、14.08,균P＜0.01);치료1주후,관찰조CRP、PTC수평분별위(4.09±1.09)mg/L、(1.95±0.25)ng/L,치료전후차이균유통계학의의(t=28.71、12.92,균P＜0.01).관찰조입원시PTC양성솔82.7％、CRP양성솔48.0％、혈배양양성솔28.0％,PTC여CRP양성솔차이유통계학의의(x2=5.64,P＜0.05),PTC여혈배양양성솔차이유통계학의의(x2=10.40,P＜0.01).PTC검측이2.5 μg/L위림계점,대패혈증적진단민감도시82.7％,특이도시80.3％.CRP검측이8 mg/L위림계점,대패혈증진단적민감도시48.7％,특이도시78.4％.결론 PTC가작위신생인패혈증조기진단유개치적지표.
Objective To assess the application value of serum procalcitonin(PCT)for the differentiation between the neonates with or without septicemia.Methods PCT,C-reactive protein(CRP),blood and blood culture tests were done in 75 cases of neonatal septicemia as the therapy group,and 74 neonates without the signs of infection as the control group after the admission of our hospital One week later,the therapy group also re-examined the PTC and CRP tests.Furthermore,the results were analyzed.Results The levels of CRP(23.26±5.68)mg/L and PCT(7.61±4.53)ng/L in therapy group were dramatically reduced compared with(4.09±1.09)mg/L,(1.95±0.25)ng/L in therapy group,and(6.42±4.54)mg/L,(0.45±0.16)ng/L in the control group before therapy,the t values are 28.71,12.97 and 19.97,14.08 respectively,and p value are both less than 0.01.The positive rates of PTC,CRP and blood culture were 82.7％,48.0％ 28.0％ before the admition to hospital.The differences of PTC and CRP,PTC and blood culture had statistical significances(x2=5.64,P＜0.05;x2=10.40,P＜0.01).If 2.5 μg/L of PCT and 8mg/L of CRP would be regarded as cutoff point in our study,the sensitivity and specificity of PCT or CRP for diagnosis of neonatal septicemia was 82.7％ and 80.3％,48.7％ and 78.4％.Conclusion Our data suggested that the serum PTC is a valuable marker for the early diagnosis of neonatal septicemia.
