CAJ | 학술논문

目的探讨宫颈环形电切术(LEEP)联合重组人干扰素α-2b栓治疗宫颈上皮内瘤变(CIN)的临床效果.方法选择经液基细胞学检查(TCT)、宫颈活检病理检查明确诊断为CIN Ⅰ～Ⅲ级患者82例,均于LEEP治疗前应用导流杂交法检测21种亚型人乳头瘤病毒(HPV DNA),均行LEEP治疗,观察组(41例)为LEEP术后加用重组人干扰素α-2b栓治疗3个疗程患者,分别于治疗后6、12个月行TCT及HPV DNA检测以判断两组的疗效.结果观察组术后6个月治愈率90.2％,术后12个月治愈率100.0％；对照组术后6个月治愈率43.9％,术后12个月治愈率61.0％；两组6、12个月治愈率差异均有统计学意义(x2=19.93、19.89,均P＜0.05).结论宫颈环形电切术联合重组人干扰素α-2b栓治疗CIN疗效优于单纯宫颈环形电切术,提高HPV清除率.
목적 탐토궁경배형전절술(LEEP)연합중조인간우소α-2b전치료궁경상피내류변(CIN)적림상효과.방법 선택경액기세포학검사(TCT)、궁경활검병리검사명학진단위CIN Ⅰ～Ⅲ급환자82례,균우LEEP치료전응용도류잡교법검측21충아형인유두류병독(HPV DNA),균행LEEP치료,관찰조(41례)위LEEP술후가용중조인간우소α-2b전치료3개료정환자,분별우치료후6、12개월행TCT급HPV DNA검측이판단량조적료효.결과 관찰조술후6개월치유솔90.2％,술후12개월치유솔100.0％；대조조술후6개월치유솔43.9％,술후12개월치유솔61.0％；량조6、12개월치유솔차이균유통계학의의(x2=19.93、19.89,균P＜0.05).결론 궁경배형전절술연합중조인간우소α-2b전치료CIN료효우우단순궁경배형전절술,제고HPV청제솔.
Objective To study the effect of combining loop electrosurgical excision procedure (LEEP) and recombinant human interferon α2b (rhIFNα-2b) suppository in treatment of cervical intraepithelial neoplasia (CIN).Methods Prospective,random and control study was conducted in 82 patients with CINⅠ-CINⅢ.Before canting out LEEP to these patients,all women were performed HPV DNA detection by the method of Hybri Max.Among these patients,41 patients were assigned to the studying group,in which the patients were given rhIFNα-2b suppository for three courses of treatment after LEEP.The other 41 patients who carried out LEEP simply were assigned to the control group.Liquid-based ThinPrep cytology test (TCT) and HPV DNA were examined in the sixth and twelfth month after treatment.Results In the studying group,the cure rate was 90.2％ when LEEP ended six months,and the cure rate was 100.0％ when LEEP ended twelve months.In the control group,the cure rate was 43.9％ when LEEP ended six months,and the cure rate was 61.0％ when LEEP ended twelve months.In the sixth and twelfth month after LEEP,the difference was significant when we compared the cure rate between the two groups (x2 =19.93,19.89,all P ＜ 0.05).Conclusion The clinical effect of combining LEEP and rhIFNα-2b suppository is better than LEEP in treatment of CIN.The method can remove or destroy the cervical lesions effectively and inhibit HPV replication and spread of HPV infection.