中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
18期
2730-2732
,共3页
丁士炬%张文武%张洁%陈兴时
丁士炬%張文武%張潔%陳興時
정사거%장문무%장길%진흥시
注意缺陷多动障碍%事件相关电位,P300
註意缺陷多動障礙%事件相關電位,P300
주의결함다동장애%사건상관전위,P300
Attention deficit disorder with hyperactivity%Event,related potentials,P300
目的 探讨注意缺陷多动障碍(ADHD)儿童事件相关电位P300的特点.方法 选择34例ADHD儿童作为ADHD组和32例健康对照者作为健康对照组.两组年龄、性别、教育程度相匹配.应用上海海神脑诱发电位仪,采用听觉Oddball刺激序列,检测和分析两组研究对象大脑中央区(Cz)和顶区(Pz)事件相关电位P300长潜伏期成分N2和P3.结果 与健康对照组比较:ADHD组Cz靶N2潜伏期延长[(277.2±20.3)ms与(259.0±14.9)ms,t=3.70,P＜0.01],靶P3波幅下降[(4.1±1.6) μV与(5.7 ±2.0) μV,t=3.57,P＜0.01].ADHD组Pz靶P3潜伏期延长[(342.4±26.3) ms与(324.6±15.5)ms,t =3.33,P＜0.01],靶P3波幅下降[(4.1±1.9)μV与(7.4 ±2.2) μV,t =6.54,P＜0.01],非靶P2波幅下降[(3.0 ±1.l)μV与(3.7±1.3)μV,t =2.30,P＜0.05].结论 ADHD儿童事件相关电位P300内源性成分存在指标异常,它们可以作为评价ADHD儿童认知功能异常的潜在客观指标.
目的 探討註意缺陷多動障礙(ADHD)兒童事件相關電位P300的特點.方法 選擇34例ADHD兒童作為ADHD組和32例健康對照者作為健康對照組.兩組年齡、性彆、教育程度相匹配.應用上海海神腦誘髮電位儀,採用聽覺Oddball刺激序列,檢測和分析兩組研究對象大腦中央區(Cz)和頂區(Pz)事件相關電位P300長潛伏期成分N2和P3.結果 與健康對照組比較:ADHD組Cz靶N2潛伏期延長[(277.2±20.3)ms與(259.0±14.9)ms,t=3.70,P＜0.01],靶P3波幅下降[(4.1±1.6) μV與(5.7 ±2.0) μV,t=3.57,P＜0.01].ADHD組Pz靶P3潛伏期延長[(342.4±26.3) ms與(324.6±15.5)ms,t =3.33,P＜0.01],靶P3波幅下降[(4.1±1.9)μV與(7.4 ±2.2) μV,t =6.54,P＜0.01],非靶P2波幅下降[(3.0 ±1.l)μV與(3.7±1.3)μV,t =2.30,P＜0.05].結論 ADHD兒童事件相關電位P300內源性成分存在指標異常,它們可以作為評價ADHD兒童認知功能異常的潛在客觀指標.
목적 탐토주의결함다동장애(ADHD)인동사건상관전위P300적특점.방법 선택34례ADHD인동작위ADHD조화32례건강대조자작위건강대조조.량조년령、성별、교육정도상필배.응용상해해신뇌유발전위의,채용은각Oddball자격서렬,검측화분석량조연구대상대뇌중앙구(Cz)화정구(Pz)사건상관전위P300장잠복기성분N2화P3.결과 여건강대조조비교:ADHD조Cz파N2잠복기연장[(277.2±20.3)ms여(259.0±14.9)ms,t=3.70,P＜0.01],파P3파폭하강[(4.1±1.6) μV여(5.7 ±2.0) μV,t=3.57,P＜0.01].ADHD조Pz파P3잠복기연장[(342.4±26.3) ms여(324.6±15.5)ms,t =3.33,P＜0.01],파P3파폭하강[(4.1±1.9)μV여(7.4 ±2.2) μV,t =6.54,P＜0.01],비파P2파폭하강[(3.0 ±1.l)μV여(3.7±1.3)μV,t =2.30,P＜0.05].결론 ADHD인동사건상관전위P300내원성성분존재지표이상,타문가이작위평개ADHD인동인지공능이상적잠재객관지표.
Objective To explore the characteristics of P300 of subjects with attention deficit/hyperactive disorder(ADHD).Methods 34 children with ADHD were selected as ADHD group and 32 healthy subjects were selected as the health control group.They were matched in age,gender,degree of education.The auditory Oddball paradigm was applied,the event-related long latency components (N2 and P3) from Cz and Pz were measured in each test.Results Compared with the health control group,at the Cz electrode,children with ADHD showed a significandy prolonged latency of target N2 [(277.2 ± 20.3) ms vs (259.0 ± 14.9) ms,t =3.70,P ＜ 0.01] and decreased amplitude of target P3[(4.1 ± 1.6) μμV vs (5.7 ±2.0) μμV,t =3.57,P＜ 0.01].At the Pz electrode,the patient showed a significantly prolonged latency [(342.4 ± 26.3) ms vs (324.6 ± 15.5) ms,t =3.33,P ＜ 0.01] and decreased amplitude of target P3 [(4.1 ± 1.9) μV vs (7.4 ± 2.2) μV,t =6.54,P ＜ 0.01],decreased amplitude of non-target P2 [(3.0±1.l)μμV vs (3.7 ±1.3) μV,t =2.30,P＜0.05].Conclusion This study provides direct evidence that ADHD subjects have abnormal indices of endogenous P300,which is suggested that P300 might be potentially objective indicator applied in evaluation of cognitive dysfunction in ADHD children.
