中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2012年
11期
1296-1299
,共4页
硅油%增殖性玻璃体视网膜病变%血管内皮生长因子%白细胞介素-6
硅油%增殖性玻璃體視網膜病變%血管內皮生長因子%白細胞介素-6
규유%증식성파리체시망막병변%혈관내피생장인자%백세포개소-6
Silicone oil%Proliferative vitreoretinopathy%Vascular endothelial growth factor%Interleukin-6
目的 检测白介素6(Interleukin-6,IL-6)和血管内皮生长因子(Vascular endothelial growth factor,VEGF)在硅油眼的前房水表达水平,并探讨其与硅油眼复发性视网膜前膜的关系.方法 研究纳入39例(40只眼)行玻璃体切除患者并采用前房穿刺方法获取前房水,其中14例(15只眼)硅油眼,15例(15只眼)增殖性玻璃体视网膜病变(Proliferative vitreoretinopathy,PVR),10例(10只眼)黄斑前膜/裂孔.硅油眼中合并复发性视网膜前/视网膜下增殖膜者共6只眼(亚组1),未合并者共9只眼(亚组2).采用ELISA方法检测前房水IL-6及VEGF浓度.结果 硅油眼前房水IL-6水平(307.33±152.68)pg/ml高于PVR组(235.35±98.41)pg/ml和黄斑前膜/裂孔组(30.18±14.3)pg/ml,差异有统计学意义.硅油眼亚组1的前房IL-6浓度(408.57±151.21)pg/ml显著高于亚组2及PVR组.硅油眼和PVR组的前房水VEGF浓度(294.94±121.81)pg/ml,(297.43±134.06)pg/ml差异无统计学意义,但均明显高于黄斑前膜/裂孔组水平(32.78±12.9)pg/ml.结论 硅油眼前房水VEGF和IL-6均高于PVR组.增生相关性因子在硅油跟的积聚可能刺激增殖膜生长从而导致视网膜复位失败.
目的 檢測白介素6(Interleukin-6,IL-6)和血管內皮生長因子(Vascular endothelial growth factor,VEGF)在硅油眼的前房水錶達水平,併探討其與硅油眼複髮性視網膜前膜的關繫.方法 研究納入39例(40隻眼)行玻璃體切除患者併採用前房穿刺方法穫取前房水,其中14例(15隻眼)硅油眼,15例(15隻眼)增殖性玻璃體視網膜病變(Proliferative vitreoretinopathy,PVR),10例(10隻眼)黃斑前膜/裂孔.硅油眼中閤併複髮性視網膜前/視網膜下增殖膜者共6隻眼(亞組1),未閤併者共9隻眼(亞組2).採用ELISA方法檢測前房水IL-6及VEGF濃度.結果 硅油眼前房水IL-6水平(307.33±152.68)pg/ml高于PVR組(235.35±98.41)pg/ml和黃斑前膜/裂孔組(30.18±14.3)pg/ml,差異有統計學意義.硅油眼亞組1的前房IL-6濃度(408.57±151.21)pg/ml顯著高于亞組2及PVR組.硅油眼和PVR組的前房水VEGF濃度(294.94±121.81)pg/ml,(297.43±134.06)pg/ml差異無統計學意義,但均明顯高于黃斑前膜/裂孔組水平(32.78±12.9)pg/ml.結論 硅油眼前房水VEGF和IL-6均高于PVR組.增生相關性因子在硅油跟的積聚可能刺激增殖膜生長從而導緻視網膜複位失敗.
목적 검측백개소6(Interleukin-6,IL-6)화혈관내피생장인자(Vascular endothelial growth factor,VEGF)재규유안적전방수표체수평,병탐토기여규유안복발성시망막전막적관계.방법 연구납입39례(40지안)행파리체절제환자병채용전방천자방법획취전방수,기중14례(15지안)규유안,15례(15지안)증식성파리체시망막병변(Proliferative vitreoretinopathy,PVR),10례(10지안)황반전막/렬공.규유안중합병복발성시망막전/시망막하증식막자공6지안(아조1),미합병자공9지안(아조2).채용ELISA방법검측전방수IL-6급VEGF농도.결과 규유안전방수IL-6수평(307.33±152.68)pg/ml고우PVR조(235.35±98.41)pg/ml화황반전막/렬공조(30.18±14.3)pg/ml,차이유통계학의의.규유안아조1적전방IL-6농도(408.57±151.21)pg/ml현저고우아조2급PVR조.규유안화PVR조적전방수VEGF농도(294.94±121.81)pg/ml,(297.43±134.06)pg/ml차이무통계학의의,단균명현고우황반전막/렬공조수평(32.78±12.9)pg/ml.결론 규유안전방수VEGF화IL-6균고우PVR조.증생상관성인자재규유근적적취가능자격증식막생장종이도치시망막복위실패.
Objective To determine the aqueous concentrations of interleukin 6(IL-6)and vascular endothelium growth factor(VEGF)in eyes with silicone oil tamponade and proliferative vitreoretinopathy(PVR).Methods Thirty-nine patients(40 eyes)underwent vitrectomy at Peking University Eye Center were enrolled in the study prospectively and aqueous samples were obtained from these vitrectomized eyes,14 patients(15 eyes)with silicone oil tamponade,15patients(10 eyes)with PVR and 10 patients(10 eyes)with idiopathic macular hole and epi-macular membrane.The silicone oil filled eyes were also divided into subgroup 1(with recurrent membranes,6 eyes)and subgroup 2(without recurrent membranes,9 eyes)according to the presence of recurrent epiretinal or subretinal membranes.The undiluted aqueous samples were collected by paracentesis and the levels of IL-6 and VEGF were analyzed by ELISA.Results The aqueous level of IL-6 in the silicone oil tamponaded eyes(307.33±152.68 pg/ml)was significantly higher than PVR(235.35±98.41 pg/ml)and idiopathic macular hole and epi-macular membrane eyes(30.18±14.3 pg/ml).The aqueous level of IL-6 in the eyes of silicone oil subgroup 1(408.57±151.21 pg/ml)was significantly higher than subgroup 2(239.84±117.02 pg/ml)and PVR eyes.There were no significant differences in the aqueous level of VEGF between silicone oil filled eyes(294.94±121.81 pg/ml)and PVR eyes(297.43±134.06 pg/ml),but both were significantly higher than the eyes with idiopathic macular hole and epi-macular membrane(32.78±12.9 pg/ml).Conclusions The aqueous levels of VEGF and IL-6 in silicone oil filled eyes are significantly higher than PVR eyes.The accumulation of proliferative cytokines such as VEGF and IL-6 in silicone oil filled eyes can stimulate the recurrence of PVR and lead to the failure of retinal detachment surgery.
