中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2013年
2期
154-158
,共5页
马英慧%刘刚%崔秀威%董微丽%付笑笑%徐辉%张铁民
馬英慧%劉剛%崔秀威%董微麗%付笑笑%徐輝%張鐵民
마영혜%류강%최수위%동미려%부소소%서휘%장철민
光学相干断层扫描%青光眼%结构%功能%相关性
光學相榦斷層掃描%青光眼%結構%功能%相關性
광학상간단층소묘%청광안%결구%공능%상관성
Optical coherence tomography%Glaucoma%Structure%Function%Correlation
目的 探讨原发性开角型青光眼(POAG)和原发性慢性闭角型青光眼(CPACG)患者频域光学相干断层扫描(OCT)检测的视网膜神经纤维层(RNFL)厚度与视野光敏感度的相关性.方法 临床观察研究.采用RTV100-20CT和OCTOPUS101视野计对POAG患者22例(22眼)及CPACG患者22例(22眼)进行检测,将两组患者RNFL厚度及视野光敏感度值进行比较,应用Pearson积矩相关分析法确定平均RNFL厚度与平均敏感度(MS)、上方和下方平均RNFL厚度与相对应半侧视野区平均敏感度的相关性.结果 POAG组平均RNFL厚度、上方平均RNFL厚度及下方平均RNFL厚度分别为(91.19±15.85) μm、(94.93±18.76) μm、(87.82±15.65) μm,CPACG组相应的RNFL厚度分别为(88.22±13.01) μm、(90.41±14.16) μm、(86.49±16.63) μm,两组患者各RNFL参数的比较差异均无统计学意义(P＞0.05).POAG组平均敏感度(MS)、上方半侧视野平均敏感度及下方半侧视野平均敏感度分别为(19.80±6.22) dB、(18.64±6.23) dB、(20.87±6.46) dB,CPACG组相应的光敏感度值分别为(16.36±3.87) dB、(15.62±4.95) dB、(17.19±5.76) dB,两组患者MS的比较差异有统计学意义(P＜0.05),上、下方半侧视野平均敏感度的比较差异均无统计学意义(P＞0.05).POAG组平均RNFL厚度、上方平均RNFL厚度及下方平均RNFL厚度与视野相对应区域光敏感度值间的相关系数分别为:0.619、0.562、0.577(P＜0.01),CPACG患者平均RNFL厚度、上方平均RNFL厚度及下方平均RNFL厚度与视野相应区域光敏感度值间的相关系数分别为0.822、0.872、0.802 (P ＜0.01),两组患者平均RNFL厚度与MS的相关系数和下方平均RNFL厚度与上方半侧视野平均敏感度的相关系数的差异均无统计学意义(P＞0.05),两组患者上方平均RNFL厚度与下方半侧视野平均敏感度的相关系数的差异有统计学意义(P＜0.05).结论 POAG结构与功能呈中度正相关,CPACG结构与功能呈高度正相关；相对于POAG,CPACG上方平均RNFL厚度与下方半侧视野平均敏感度具有更好的相关性.
目的 探討原髮性開角型青光眼(POAG)和原髮性慢性閉角型青光眼(CPACG)患者頻域光學相榦斷層掃描(OCT)檢測的視網膜神經纖維層(RNFL)厚度與視野光敏感度的相關性.方法 臨床觀察研究.採用RTV100-20CT和OCTOPUS101視野計對POAG患者22例(22眼)及CPACG患者22例(22眼)進行檢測,將兩組患者RNFL厚度及視野光敏感度值進行比較,應用Pearson積矩相關分析法確定平均RNFL厚度與平均敏感度(MS)、上方和下方平均RNFL厚度與相對應半側視野區平均敏感度的相關性.結果 POAG組平均RNFL厚度、上方平均RNFL厚度及下方平均RNFL厚度分彆為(91.19±15.85) μm、(94.93±18.76) μm、(87.82±15.65) μm,CPACG組相應的RNFL厚度分彆為(88.22±13.01) μm、(90.41±14.16) μm、(86.49±16.63) μm,兩組患者各RNFL參數的比較差異均無統計學意義(P＞0.05).POAG組平均敏感度(MS)、上方半側視野平均敏感度及下方半側視野平均敏感度分彆為(19.80±6.22) dB、(18.64±6.23) dB、(20.87±6.46) dB,CPACG組相應的光敏感度值分彆為(16.36±3.87) dB、(15.62±4.95) dB、(17.19±5.76) dB,兩組患者MS的比較差異有統計學意義(P＜0.05),上、下方半側視野平均敏感度的比較差異均無統計學意義(P＞0.05).POAG組平均RNFL厚度、上方平均RNFL厚度及下方平均RNFL厚度與視野相對應區域光敏感度值間的相關繫數分彆為:0.619、0.562、0.577(P＜0.01),CPACG患者平均RNFL厚度、上方平均RNFL厚度及下方平均RNFL厚度與視野相應區域光敏感度值間的相關繫數分彆為0.822、0.872、0.802 (P ＜0.01),兩組患者平均RNFL厚度與MS的相關繫數和下方平均RNFL厚度與上方半側視野平均敏感度的相關繫數的差異均無統計學意義(P＞0.05),兩組患者上方平均RNFL厚度與下方半側視野平均敏感度的相關繫數的差異有統計學意義(P＜0.05).結論 POAG結構與功能呈中度正相關,CPACG結構與功能呈高度正相關；相對于POAG,CPACG上方平均RNFL厚度與下方半側視野平均敏感度具有更好的相關性.
목적 탐토원발성개각형청광안(POAG)화원발성만성폐각형청광안(CPACG)환자빈역광학상간단층소묘(OCT)검측적시망막신경섬유층(RNFL)후도여시야광민감도적상관성.방법 림상관찰연구.채용RTV100-20CT화OCTOPUS101시야계대POAG환자22례(22안)급CPACG환자22례(22안)진행검측,장량조환자RNFL후도급시야광민감도치진행비교,응용Pearson적구상관분석법학정평균RNFL후도여평균민감도(MS)、상방화하방평균RNFL후도여상대응반측시야구평균민감도적상관성.결과 POAG조평균RNFL후도、상방평균RNFL후도급하방평균RNFL후도분별위(91.19±15.85) μm、(94.93±18.76) μm、(87.82±15.65) μm,CPACG조상응적RNFL후도분별위(88.22±13.01) μm、(90.41±14.16) μm、(86.49±16.63) μm,량조환자각RNFL삼수적비교차이균무통계학의의(P＞0.05).POAG조평균민감도(MS)、상방반측시야평균민감도급하방반측시야평균민감도분별위(19.80±6.22) dB、(18.64±6.23) dB、(20.87±6.46) dB,CPACG조상응적광민감도치분별위(16.36±3.87) dB、(15.62±4.95) dB、(17.19±5.76) dB,량조환자MS적비교차이유통계학의의(P＜0.05),상、하방반측시야평균민감도적비교차이균무통계학의의(P＞0.05).POAG조평균RNFL후도、상방평균RNFL후도급하방평균RNFL후도여시야상대응구역광민감도치간적상관계수분별위:0.619、0.562、0.577(P＜0.01),CPACG환자평균RNFL후도、상방평균RNFL후도급하방평균RNFL후도여시야상응구역광민감도치간적상관계수분별위0.822、0.872、0.802 (P ＜0.01),량조환자평균RNFL후도여MS적상관계수화하방평균RNFL후도여상방반측시야평균민감도적상관계수적차이균무통계학의의(P＞0.05),량조환자상방평균RNFL후도여하방반측시야평균민감도적상관계수적차이유통계학의의(P＜0.05).결론 POAG결구여공능정중도정상관,CPACG결구여공능정고도정상관；상대우POAG,CPACG상방평균RNFL후도여하방반측시야평균민감도구유경호적상관성.
Objective To explore the correlations between retinal nerve fiber layer (RNFL) thickness measured with spectral domain optical coherence tomography (OCT) and visual field light sensitivity in POAG and CPACG.Methods Twenty-two patients (22 eyes) with POAG and 22 patients (22 eyes) with CPACG were examined by using RTV100-2OCT and OCTOPUS101 visual field analyzer.The RNFL thickness and visual field light sensitivity in the two groups of patients were compared.Correlations between RNFL thickness and visual field light sensitivity were determined by Pearson product moment correlation analysis.Results In POAG group,the average RNFL thickness,superior average RNFL thickness and inferior average RNFL thickness were (91.19±15.85)μm,(94.93±18.76)μm,(87.82±15.65)μm,respectively; in CPACG group,the corresponding RNFL thickness were (88.22 ± 13.01)μm,(90.41 ± 14.16)μm,(86.49 ± 16.63)μm,respectively; differences of RNFL parameters was not significant between POAG group and CPACG group (P ＞0.05).In POAG group,mean sensitivity (MS),superior hemi-visual field average sensitivity and inferior hemi-visual field average sensitivity were (19.80±6.22)dB,(18.64±6.23)dB,(20.87±6.46)dB,respectively; in CPACG group,the corresponding sensitivity were (16.36±3.87)dB,(15.62±4.95)dB,(17.19±5.76)dB,respectively; differences of MS was significant between POAG group and CPACG group (P ＜0.05),differences of superior and inferior hemi-visual field average sensitivity was not significant between POAG group and CPACG group (P ＞0.05).In POAG group,average RNFL thickness,superior and inferior average RNFL thickness were correlated with average sensitivity of the corresponding visual field with the significant correlation coefficient 0.619,0.562,0.577,respectively (P ＜0.01); in CPACG group,average RNFL thickness,superior and inferior average RNFL thickness were correlated with average sensitivity of the corresponding visual field with the significant correlation coefficient 0.822,0.872,0.802,respectively (P ＜0.01).The differences of correlation coefficient between average RNFL thickness,inferior average RNFL thickness with average sensitivity of the corresponding visual field was not significant in the two groups (P ＞0.05).The differences of correlation coefficient between superior average RNFL thickness with inferior hemi-visual field average sensitivity was significant in the two groups (P ＜0.05).Conclusions POAG eyes have moderate positive structure-function correlations.CPACG eyes have high positive structure-function correlations.Compared with POAG eyes,CPACG has better correlations between superior average RNFL thickness and inferior hemi-visual field average sensitivity.
