中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2013年
3期
259-262
,共4页
何美芹%徐延山%王兰惠%郑曰忠
何美芹%徐延山%王蘭惠%鄭曰忠
하미근%서연산%왕란혜%정왈충
黄斑区视网膜前膜%光相干断层扫描%多焦视网膜电图%一阶函数核
黃斑區視網膜前膜%光相榦斷層掃描%多焦視網膜電圖%一階函數覈
황반구시망막전막%광상간단층소묘%다초시망막전도%일계함수핵
Idiopathic epimacular membrane%Optical coherent tomography%Multifocal electroretinogram%First order kernel
目的 探讨特发性黄斑前膜(idiopathic macular epiretinal membrane,IMEM)的频域光相干断层扫描(frequency-domain optical coherent tomography,fdOCT)与多焦视网膜电图(multifocal electroretinogram,mfERG)的特征、相关性以及与视力的关系.方法 临床病例自身对照研究.收集2012年1月至5月就诊于天津市眼科医院,经检眼镜和fdOCT或荧光素眼底血管造影检查确诊的单侧特发性黄斑前膜患者30例,进行mfERG检查,对侧正常眼数据作为对照组,分析其黄斑区形态与功能的相关性,以及对视力的影响.结果 30只患眼的最佳矫正视力(best-corrected visual acuity,BCVA)为0.02～1.0 (0.62±0.27),fdOCT显示黄斑中心凹、旁中心凹、中心凹周围区视网膜平均厚度与对侧眼比较,差异均有统计学意义(P＜0.05).mfERG各波反应与对侧眼比较,1～5环P1波的振幅密度和N1波的潜伏期差异有统计学意义(P＜0.05),N1波振幅密度除1、2环外,差异均无统计学意义.患眼组视力与所对应的黄斑中心凹视网膜厚度之间存在明显的负相关(r =-0.615,P=0.001),视力与mfERG 1环P1、N1波振幅无关,与潜伏期有关(P＜0.05).结论 IMEM导致中心凹视网膜越厚,视力越差,但与视功能损害程度不一致,OCT和mfERG联合应用能更全面地评估IMEM对黄斑区结构和功能的影响.
目的 探討特髮性黃斑前膜(idiopathic macular epiretinal membrane,IMEM)的頻域光相榦斷層掃描(frequency-domain optical coherent tomography,fdOCT)與多焦視網膜電圖(multifocal electroretinogram,mfERG)的特徵、相關性以及與視力的關繫.方法 臨床病例自身對照研究.收集2012年1月至5月就診于天津市眼科醫院,經檢眼鏡和fdOCT或熒光素眼底血管造影檢查確診的單側特髮性黃斑前膜患者30例,進行mfERG檢查,對側正常眼數據作為對照組,分析其黃斑區形態與功能的相關性,以及對視力的影響.結果 30隻患眼的最佳矯正視力(best-corrected visual acuity,BCVA)為0.02～1.0 (0.62±0.27),fdOCT顯示黃斑中心凹、徬中心凹、中心凹週圍區視網膜平均厚度與對側眼比較,差異均有統計學意義(P＜0.05).mfERG各波反應與對側眼比較,1～5環P1波的振幅密度和N1波的潛伏期差異有統計學意義(P＜0.05),N1波振幅密度除1、2環外,差異均無統計學意義.患眼組視力與所對應的黃斑中心凹視網膜厚度之間存在明顯的負相關(r =-0.615,P=0.001),視力與mfERG 1環P1、N1波振幅無關,與潛伏期有關(P＜0.05).結論 IMEM導緻中心凹視網膜越厚,視力越差,但與視功能損害程度不一緻,OCT和mfERG聯閤應用能更全麵地評估IMEM對黃斑區結構和功能的影響.
목적 탐토특발성황반전막(idiopathic macular epiretinal membrane,IMEM)적빈역광상간단층소묘(frequency-domain optical coherent tomography,fdOCT)여다초시망막전도(multifocal electroretinogram,mfERG)적특정、상관성이급여시력적관계.방법 림상병례자신대조연구.수집2012년1월지5월취진우천진시안과의원,경검안경화fdOCT혹형광소안저혈관조영검사학진적단측특발성황반전막환자30례,진행mfERG검사,대측정상안수거작위대조조,분석기황반구형태여공능적상관성,이급대시력적영향.결과 30지환안적최가교정시력(best-corrected visual acuity,BCVA)위0.02～1.0 (0.62±0.27),fdOCT현시황반중심요、방중심요、중심요주위구시망막평균후도여대측안비교,차이균유통계학의의(P＜0.05).mfERG각파반응여대측안비교,1～5배P1파적진폭밀도화N1파적잠복기차이유통계학의의(P＜0.05),N1파진폭밀도제1、2배외,차이균무통계학의의.환안조시력여소대응적황반중심요시망막후도지간존재명현적부상관(r =-0.615,P=0.001),시력여mfERG 1배P1、N1파진폭무관,여잠복기유관(P＜0.05).결론 IMEM도치중심요시망막월후,시력월차,단여시공능손해정도불일치,OCT화mfERG연합응용능경전면지평고IMEM대황반구결구화공능적영향.
ObJective To investigate the features and correlation of frequency-domain optical coherent tomography (fdOCT) and multifocal electroretinogram (mfERG) in patients with idiopathic macular epiretinal membrane (IMEM),and visual acuity.Methods Thirty patients with unilateral IMEM were collected,which diagnosed by visual acuity,ophthalmoscope,OCT or fundus fluorescein angiography in Tianjin Eye Hospital from January to May of 2012,and then checked mfERG.The data from contralateral normal eyes was used as the control group.The relationship between the results of macular morphology and function were analyzed,and the effect on visual acuity was also included.Results The best-corrected visual acuities of 30 eyes ranged from 0.02 to 1.0 (average 0.62±0.27).fdOCT revealed that there was significantly statistical difference in the retinal thickness about macular fovea,parafovea and perifovea between diseases eyes and contralateral eyes (P ＜0.05).mfERG revealed that there was a significant difference in the amplitude densities of PI wave and the latencies of N1 wave at ring 1 to 5 (P ＜0.05).There was no statistical difference in the amplitude densities of N1 wave except ring 1 and 2.The foveal thickening was negatively correlated with visual acuity (r =-0.615,P =0.001).The latencies of PI,N1 wave at ring 1 had effect on visual acuity (P ＜0.05),however,the amplitude densities were not.Conclusions The visual acuity can be worse with the increase of central retinal thickness which caused by IMEM,but that is inconsistent with the degree of functional impairment.The combination of OCT and mfERG have better evaluation in the effect of IMEM on macular anatomical and functional outcomes.
