CAJ | 학술논문

目的观察单纯玻璃酸钠治疗与玻璃酸钠联合重组牛碱性成纤维细胞生长因子治疗对糖尿病患者白内障术后泪膜的动态变化.方法临床病例治疗对照研究.对2011年5月至2012年5月在上海市第一人民医院分院眼科就诊的白内障超声乳化术的糖尿病患者86例125只眼,分为对照组(A组45只眼)、玻璃酸钠治疗组(B组43只眼)和联合治疗组(C组37只眼).在术前、术后1天、术后1周、术后1月进行主观干眼感觉、泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)及角膜荧光素染色(FL)检查.结果 3组术后与术前比较,干眼主观症状增多、BUT明显缩短、SIt和FL明显增多.术后1月,A组干眼主观症状、BUT和FL与术前相比仍具有统计学意义(P＜0.01).与术前相比,B组SIt和FL术后1周、干眼主观症状和BUT术后1月接近术前水平.C组术后1周干眼主观症状、BUT、SIt和FL接近术前水平(P＞0.05).结论糖尿病患者行白内障超声乳化手术后早期使用玻璃酸钠与重组牛碱性成纤维细胞生长因子联合治疗,更有利于改善症状、恢复泪膜稳定性.
목적 관찰단순파리산납치료여파리산납연합중조우감성성섬유세포생장인자치료대당뇨병환자백내장술후루막적동태변화.방법 림상병례치료대조연구.대2011년5월지2012년5월재상해시제일인민의원분원안과취진적백내장초성유화술적당뇨병환자86례125지안,분위대조조(A조45지안)、파리산납치료조(B조43지안)화연합치료조(C조37지안).재술전、술후1천、술후1주、술후1월진행주관간안감각、루막파렬시간(BUT)、기출루액분비시험(SIt)급각막형광소염색(FL)검사.결과 3조술후여술전비교,간안주관증상증다、BUT명현축단、SIt화FL명현증다.술후1월,A조간안주관증상、BUT화FL여술전상비잉구유통계학의의(P＜0.01).여술전상비,B조SIt화FL술후1주、간안주관증상화BUT술후1월접근술전수평.C조술후1주간안주관증상、BUT、SIt화FL접근술전수평(P＞0.05).결론 당뇨병환자행백내장초성유화수술후조기사용파리산납여중조우감성성섬유세포생장인자연합치료,경유리우개선증상、회복루막은정성.
Objective To study the efficacy of the combined treatment with sodium hyaluronate (HA) and recombinant bovine basic fibroblast growth factor (r-bFGF) for Ⅱ-diabetic patients after phacoemulsification.Methods A total of 86 Ⅱ-diabetic patients undergoing phacoemulsification were randomized divided into control group (group A,45 eyes with conventional therapy),single treatment group (group B,43 eyes with conventional therapy and HA) and combined treatment group (group C,37 eyes with conventional therapy,HA and r-bFGF).Subjective symptoms,tear film break-up time (BUT),Schirmer I test (SIt) and corneal fluorescein staining (FL) were measured preoperatively and 1 day,1 week and 1 month postoperatively.Results In all groups,the BUT reduced greatly,SIt value and FL increased significantly after phacoemulsification.Compared with preoperations in group A,subjective complains of dry eye increased and the BUT reduced in 1 day,1 week and 1 month postoperatively.So did FL.SIt value returned at postoperative value at 1 month after operations.In group B,SIt value and FL returned to postoperative value at postoperative 1 week,so did subjective complains of dry eye and BUT at postoperative 1 month.There were no significant differences in subjective complains of dry eye,BUT,SIt and FL in group C in 1 week after phacoemulsification.Conclusions It can be more effective to relieve the dry eye symptoms for Ⅱ-diabetic patients to use combined treatment with HA and r-bFGF at early stage after phacoemulsification.