CAJ | 학술논문

目的探讨原发性闭角型青光眼(Primary close-angle glaucoma,PACG)患阿尔茨海默病(Alzheimer's disease,AD)发病率及其关联性.方法采用前瞻性随机临床对照的方法.对300例青光眼患者(A组)进行阿尔茨海默病筛查,选择年龄、性别等人口学情况相匹配的健康对照者300名(B组)作为对照,分析并比较两组AD患者检出情况,分析PACG与AD相关性.结果 PACG组含AD患者38例,占12.7％,正常组含AD患者22例,占7.3％,两组比较差异有统计学意义(P＜0.05).两组各年龄段发病率比较差异均无统计学意义(P＞0.05).单因素及多因素分析提示青光眼病程、严重程度与MMSE评分呈负相关(P＜0.05),与年龄、AD病程、AD严重程度呈正相关(P＜0.05),与性别、AD临床类型、AD家族史无相关性(P＞0.05).结论 PACG可能与AD的发生存在一定关系,临床监测和控制青光眼病情可为AD的防治提供实验室依据.
목적 탐토원발성폐각형청광안(Primary close-angle glaucoma,PACG)환아이자해묵병(Alzheimer's disease,AD)발병솔급기관련성.방법 채용전첨성수궤림상대조적방법.대300례청광안환자(A조)진행아이자해묵병사사,선택년령、성별등인구학정황상필배적건강대조자300명(B조)작위대조,분석병비교량조AD환자검출정황,분석PACG여AD상관성.결과 PACG조함AD환자38례,점12.7％,정상조함AD환자22례,점7.3％,량조비교차이유통계학의의(P＜0.05).량조각년령단발병솔비교차이균무통계학의의(P＞0.05).단인소급다인소분석제시청광안병정、엄중정도여MMSE평분정부상관(P＜0.05),여년령、AD병정、AD엄중정도정정상관(P＜0.05),여성별、AD림상류형、AD가족사무상관성(P＞0.05).결론 PACG가능여AD적발생존재일정관계,림상감측화공제청광안병정가위AD적방치제공실험실의거.
Objective To discuss the relationship between primary angle-closure glaucoma (PACG) and Alzheimer's disease (AD).Methods Totally 300 cases of PACG patients (observation group,group A) and 300 cases of non-glaucoma controls (control group,group B) were investigated with l:l matched cases-control study.The relationship of PACG and AD in both subjects were detected and compared the detection rate.Results There were 38 AD patients in Group A (12.7％) and 20 AD patients in Group B (7.3％).There was a significant difference in the detection rate of AD between two groups (P ＜0.05),whereas there was no significant difference in the detection rate of different age degree AD between two groups (P ＜0.05).Logistic analysis results showed PACG history and severity were positive correlated with age,AD history and AD severity (P ＜0.05),and negative correlated with MMSE (P ＜0.05).There were no correlated with sex,clinical type and family history (P ＞0.05).Conclusions PACG is possibly correlated to AD.To monitor and control the condition of glaucoma can provide a clinical basis for preventing and treating AD.