CAJ | 학술논문

目的观察湿性年龄相关性黄斑变性(AMD)患者血清炎症相关因子水平的改变.方法回顾性临床病例对照研究.对2012年12月至2013年8月在解放军第四七四医院眼科中心就诊的55例临床确诊为湿性AMD患者为湿性AMD组,测其血清中的炎症因子水平;再选取33例老年性白内障患者的血清作为正常对照组,称为白内障对照组.分别抽取两组受试者静脉血,采用酶联免疫吸附剂测定血清中单核细胞趋化蛋白1(MCP-1)、转化生长因子β1 (TGF-β1)及白介素6(IL-6)的浓度.结果湿性AMD组与老年性白内障对照组血清TGF-β1、IL-6浓度比较,差异有统计学意义(Z =-3.228,P=0.001,P＜0.05;Z=-2.034,P=0.042,P＜0.05);湿性AMD组与老年性白内障对照组血清MCP-1浓度比较,差异无统计学意义(Z=-1.832,P=0.067,P＞0.05).结论血清中TGF-β1、IL-6可以作为生物标记物来检测湿性AMD的进展.
목적 관찰습성년령상관성황반변성(AMD)환자혈청염증상관인자수평적개변.방법 회고성림상병례대조연구.대2012년12월지2013년8월재해방군제사칠사의원안과중심취진적55례림상학진위습성AMD환자위습성AMD조,측기혈청중적염증인자수평;재선취33례노년성백내장환자적혈청작위정상대조조,칭위백내장대조조.분별추취량조수시자정맥혈,채용매련면역흡부제측정혈청중단핵세포추화단백1(MCP-1)、전화생장인자β1 (TGF-β1)급백개소6(IL-6)적농도.결과 습성AMD조여노년성백내장대조조혈청TGF-β1、IL-6농도비교,차이유통계학의의(Z =-3.228,P=0.001,P＜0.05;Z=-2.034,P=0.042,P＜0.05);습성AMD조여노년성백내장대조조혈청MCP-1농도비교,차이무통계학의의(Z=-1.832,P=0.067,P＞0.05).결론 혈청중TGF-β1、IL-6가이작위생물표기물래검측습성AMD적진전.
Objective To observed the change of serum inflammatory-associated cytokines concentrations in the patients with wet age-related macular degeneration.Methods Retrospective analysis was made to the serum inflammatory cytokines of the 55 patients with wet AMD.The serum of 33 patients with senile cataract was selected as the control group.Serous concentrations of TGF-β1,IL-6,and MCP-1 were examined by enzyme-linked immunosorbent assay (ELISA).Results The levels of TGF-β 1,IL-6 in wet AMD group were significantly higher than that in control group (Z =-3.228,P =0.001; Z =-2.034,P =0.042).The level of MCP-1 was not significantly different between the two groups (Z =-1.832,P =0.067).Conclusions The serum inflammatory-associated cytokines TGF-β1,IL-6 may be the biomarker to monitor the progression of wet AMD.