CAJ | 학술논문

目的评价视神经炎伴多发性硬化患者的眼球后血流动力学改变,并与健侧眼及健康对照组眼对比.方法回顾性分析34例单侧视神经炎伴多发性硬化的患者以及32名健康受试者.通过超声多普勒成像检查罹患视神经炎一侧眼的眼动脉、睫状后动脉和视网膜中央动脉的收缩峰值和舒张末血流速以及阻力指数.然后将这些数值与健侧眼以及健康受试者正常眼作比较.统计学方法分别采用配对t检验和非配对t检验.结果将视神经炎眼、对侧未累及眼以及健康对照眼,进行平均球后血流速度、平均阻力指数比较,差异无统计学意义(P＞0.05).和对照眼相比,视神经炎眼的视网膜中央动脉的平均舒张末血流速度较低(P=0.04),视网膜中央动脉(P=0.02)和睫状后动脉(P=0.009)的平均阻力指数较高,其差异均有统计学意义P ＜0.05.在患者有多发性硬化的患者中,和未累及的对侧眼相比,在睫状后动脉(P=0.02)和视网膜中央动脉(P=0.04)患有视神经炎侧眼具有更高的阻力指数,差异有统计学意义P ＜0.05.球后血流速度和所有血管的阻力指数在未累及的对侧眼和正常对照眼差异无统计学意义(P＞0.05).结论研究提示与对侧未累及眼以及健康对照眼相比,视神经炎伴多发性硬化与球后血流动力学受损相关,尤其在睫状后动脉和视网膜中央动脉.但是两者的因果关系有待于进一步论证.
목적 평개시신경염반다발성경화환자적안구후혈류동역학개변,병여건측안급건강대조조안대비.방법 회고성분석34례단측시신경염반다발성경화적환자이급32명건강수시자.통과초성다보륵성상검사리환시신경염일측안적안동맥、첩상후동맥화시망막중앙동맥적수축봉치화서장말혈류속이급조력지수.연후장저사수치여건측안이급건강수시자정상안작비교.통계학방법분별채용배대t검험화비배대t검험.결과 장시신경염안、대측미루급안이급건강대조안,진행평균구후혈류속도、평균조력지수비교,차이무통계학의의(P＞0.05).화대조안상비,시신경염안적시망막중앙동맥적평균서장말혈류속도교저(P=0.04),시망막중앙동맥(P=0.02)화첩상후동맥(P=0.009)적평균조력지수교고,기차이균유통계학의의P ＜0.05.재환자유다발성경화적환자중,화미루급적대측안상비,재첩상후동맥(P=0.02)화시망막중앙동맥(P=0.04)환유시신경염측안구유경고적조력지수,차이유통계학의의P ＜0.05.구후혈류속도화소유혈관적조력지수재미루급적대측안화정상대조안차이무통계학의의(P＞0.05).결론 연구제시여대측미루급안이급건강대조안상비,시신경염반다발성경화여구후혈류동역학수손상관,우기재첩상후동맥화시망막중앙동맥.단시량자적인과관계유대우진일보론증.
Objective To evaluate retrobulbar hemodynamics in patients with optic neuritis associated with multiple sclerosis,and compare with the contralateral eye and the eyes of the healthy control group.Methods From the list of neurology side neuritis recruit 34 patients with multiple sclerosis and 32 healthy subjects.By ultrasound Doppler imaging optic neuritis side of the eye suffering from eye artery,posterior ciliary artery and central retinal artery peak systolic and diastolic blood flow velocity and resistance index (resistivity index).Then these values in healthy subjects with normal contralateral eye and the eye were as comparison.Statistical methods were used paired t test and unpaired t test.Results The optic neuritis eyes,not involving the contralateral eye,as well as healthy control eyes,mean blood flow velocity after the ball,the average resistance index was no significant difference (P ＞0.05).And compared with control eyes,optic neuritis eye mean central retinal artery diastolic flow velocity was low (P =0.04),central retinal artery (P =0.02) and post-ciliary artery (P =0.009),the average resistance index higher.In patients with multiple sclerosis patients,and not involving the contralateral eye compared ciliary artery (P =0.02),and central retinal artery (P =0.04) with optic neuritis with higher resistance to lateral eye index.Retrobulbar blood flow velocity and vascular resistance index all without involving the contralateral eye and normal control eyes was no significant difference (P ＞0.05).Conclusions This study suggests that multiple sclerosis and optic neuritis is related with retrobulbar hemodynamics related damage,especially in the ciliary artery and central retinal arteries.However,a causal relationship between the two remains to be demonstrated.